HitPredict

Interactor 1: TPM1 (P09493)
Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)
Gene: TPM1

Interactor 2: SCLT1 (Q96NL6)
Sodium channel and clathrin linker 1 (Sodium channel-associated protein 1)
Gene: SCLT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 284 Hs			1 688
+	Rn
		1186812 MRCKB_RAT (1-283): 1.5e-32: 128: 19.60		MRCKB_RAT (89-586): 1.39e-41: 165: 17.76
+	Dm
		419108 TPM1_DROME (1-281): 3.07e-56: 186: 44.78		MYSN_DROME (227-688): 3.23e-19: 95: 12.55
+	Hs
		1137917 MRCKA_HUMAN (1-282): 1.08e-31: 126: 17.67		MRCKB_HUMAN (89-586): 3.29e-38: 154: 17.57
+	Hs
		451293 TPM1_HUMAN (1-284): 2.35e-44: 153: 100.00		MY18A_HUMAN (82-659): 3.07e-13: 75.6: 21.14
+	Hs
		419011 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		MY18A_HUMAN (82-659): 3.07e-13: 75.6: 21.14
+	Rn
		222476 MRCKB_RAT (1-283): 1.5e-32: 128: 19.60		MRCKA_RAT (9-517): 9.04e-19: 93.6: 13.59
+	Hs
		451201 TPM1_HUMAN (1-284): 2.35e-44: 153: 100.00		MYH9_HUMAN (311-686): 8.81e-11: 67.7: 10.91
+	Hs
		418895 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		MYH9_HUMAN (311-686): 8.81e-11: 67.7: 10.91
+	Hs
		419054 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		MYO5C_HUMAN (70-548): 4.02e-10: 65.6: 22.29
+	Hs
		148289 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		CTRO_HUMAN (250-676): 6.69e-10: 64.8: 21.32
+	Hs
		434415 TPM2_HUMAN (1-284): 1.39e-38: 138: 85.56		MY18A_HUMAN (82-659): 3.07e-13: 75.6: 21.14
+	Hs
		1137871 MRCKA_HUMAN (1-282): 1.08e-31: 126: 17.67		MRCKA_HUMAN (16-496): 7.85e-15: 80.9: 13.98
+	Hs
		434354 TPM2_HUMAN (1-284): 1.39e-38: 138: 85.56		MYH9_HUMAN (311-686): 8.81e-11: 67.7: 10.91
+	Hs
		434437 TPM2_HUMAN (1-284): 1.39e-38: 138: 85.56		MYO5C_HUMAN (70-548): 4.02e-10: 65.6: 22.29
+	Hs
		110802 H7BYY1_HUMAN (41-284): 8.14e-35: 127: 70.49		MY18A_HUMAN (82-659): 3.07e-13: 75.6: 21.14
+	Hs
		932031 TPM4_HUMAN (42-284): 3.76e-33: 123: 68.72		MY18A_HUMAN (82-659): 3.07e-13: 75.6: 21.14
+	Hs
		110796 H7BYY1_HUMAN (41-284): 8.14e-35: 127: 70.49		MYH9_HUMAN (311-686): 8.81e-11: 67.7: 10.91
+	Dm
		404216 TPM2_DROME (1-282): 7.75e-35: 128: 49.29		MYSA_DROME (313-688): 5.36e-10: 65: 12.30
+	Hs
		724765 TPM4_HUMAN (42-284): 3.76e-33: 123: 68.72		MYH9_HUMAN (311-686): 8.81e-11: 67.7: 10.91
+	Hs
		148661 TPM4_HUMAN (42-284): 3.76e-33: 123: 68.72		CTRO_HUMAN (250-676): 6.69e-10: 64.8: 21.32