Protein: MKRN3
Probable E3 ubiquitin-protein ligase makorin-3 (EC 2.3.2.27) (RING finger protein 63) (RING-type E3 ubiquitin transferase makorin-3) (Zinc finger protein 127)

Gene: MKRN3
Organism: Homo sapiens
Interactions: 221
UniProt ID: Q13064

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0003723 - RNA binding
GO:0016567 - protein ubiquitination
GO:0042802 - identical protein binding
GO:0046872 - metal ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

849317

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

14

Small-scale

0.910

High

1023454

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

4

6

High-throughput

0.904

High

896304

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

18

High-throughput

0.783

High

169283

MDM4
Protein Mdm4

4

1

High-throughput

0.706

High

1023515

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

5

0

High-throughput

0.699

High

851809

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

14

High-throughput

0.698

High

895784

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

14

High-throughput

0.698

High

896430

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

14

High-throughput

0.698

High

908461

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

14

High-throughput

0.698

High

919716

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

14

High-throughput

0.698

High

930184

UBC9
SUMO-conjugating enzyme UBC9

1

14

High-throughput

0.698

High

932506

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

15

High-throughput

0.698

High

1023458

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

16

High-throughput

0.698

High

1023465

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

16

High-throughput

0.698

High

1023485

TRI65
E3 ubiquitin-protein ligase TRIM65

1

3

High-throughput

0.698

High

1023526

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

15

High-throughput

0.698

High

1023552

TRI34
E3 ubiquitin-protein ligase TRIM34

1

1

High-throughput

0.698

High

1023554

TRI31
E3 ubiquitin-protein ligase TRIM31

1

2

High-throughput

0.698

High

1023555

TRIM5
Tripartite motif-containing protein 5

1

2

High-throughput

0.698

High

1023586

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

14

High-throughput

0.698

High

516487

PABP1
Polyadenylate-binding protein 1

3

11

Small-scale

0.670

High

734612

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.663

High

473660

ZN688
Zinc finger protein 688

3

3

High-throughput

0.654

High

1023549

SCNM1
Sodium channel modifier 1

3

0

High-throughput

0.646

High

1023551

BEX2
Protein BEX2

3

0

High-throughput

0.646

High

1023547

TCHP
Trichoplein keratin filament-binding protein

4

2

High-throughput

0.637

High

1023522

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

14

High-throughput

0.625

High

1023535

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

14

High-throughput

0.625

High

1023479

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

14

High-throughput

0.621

High

1023557

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

8

High-throughput

0.618

High

1023579

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

8

High-throughput

0.618

High

1023456

PABP4
Polyadenylate-binding protein 4

2

11

Small-scale

0.611

High

1023561

PABP3
Polyadenylate-binding protein 3

2

11

Small-scale

0.611

High

1023518

LAR4B
La-related protein 4B

2

11

High-throughput

0.611

High

69236

MI4GD
MIF4G domain-containing protein

2

3

High-throughput

0.606

High

70977

ZBT42
Zinc finger and BTB domain-containing protein 42

2

2

High-throughput

0.606

High

1023457

KLF1
Krueppel-like factor 1

2

3

High-throughput

0.606

High

1023461

LASP1
LIM and SH3 domain protein 1

2

1

High-throughput

0.606

High

1023580

IKZF3
Zinc finger protein Aiolos

2

3

High-throughput

0.606

High

1023520

RENT1
Regulator of nonsense transcripts 1

2

7

Small-scale

0.584

High

1023565

MOV10
Helicase MOV-10

2

7

Small-scale

0.584

High

135614

NDKM
Nucleoside diphosphate kinase, mitochondrial

2

0

High-throughput

0.580

High

159981

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

0

High-throughput

0.580

High

448634

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.580

High

871369

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

0

High-throughput

0.580

High

1023462

RTP5
Receptor-transporting protein 5

2

0

High-throughput

0.580

High

1023523

TET5B
Terminal nucleotidyltransferase 5B

2

0

High-throughput

0.580

High

1023532

ZN414
Zinc finger protein 414

2

0

High-throughput

0.580

High

1023539

ZN587
Zinc finger protein 587

2

0

High-throughput

0.580

High

1023556

IN80B
INO80 complex subunit B

2

0

High-throughput

0.580

High

1023564

SMYD3
Histone-lysine N-methyltransferase SMYD3

2

0

High-throughput

0.580

High

1023568

ZFP57
Zinc finger protein 57 homolog

2

0

High-throughput

0.580

High

1023584

ZN835
Zinc finger protein 835

2

0

High-throughput

0.580

High

1023464

SF01
Splicing factor 1

1

3

High-throughput

0.573

High

1023521

RBPMS
RNA-binding protein with multiple splicing

1

2

High-throughput

0.560

High

213942

KRT86
Keratin, type II cuticular Hb6

2

1

High-throughput

0.553

High

235498

VINEX
Vinexin

2

1

High-throughput

0.553

High

266348

TAD2A
Transcriptional adapter 2-alpha

2

1

High-throughput

0.553

High

280573

KRT34
Keratin, type I cuticular Ha4

2

3

High-throughput

0.553

High

318800

K2C75
Keratin, type II cytoskeletal 75

2

1

High-throughput

0.553

High

442820

HCK
Tyrosine-protein kinase HCK

2

1

High-throughput

0.553

High

723662

HXD12
Homeobox protein Hox-D12

2

3

High-throughput

0.553

High

829842

HXA1
Homeobox protein Hox-A1

2

3

High-throughput

0.553

High

837797

MEOX1
Homeobox protein MOX-1

2

3

High-throughput

0.553

High

1016943

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

2

1

High-throughput

0.553

High

1020628

TRAF2
TNF receptor-associated factor 2

2

4

High-throughput

0.553

High

1023459

PTK6
Protein-tyrosine kinase 6

2

1

High-throughput

0.553

High

1023468

RSPO4
R-spondin-4

2

1

High-throughput

0.553

High

1023480

TASO2
Protein TASOR 2

2

1

High-throughput

0.553

High

1023482

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

5

High-throughput

0.553

High

1023483

WDR25
WD repeat-containing protein 25

2

3

High-throughput

0.553

High

1023484

MORN3
MORN repeat-containing protein 3

2

1

High-throughput

0.553

High

1023492

RBPS2
RNA-binding protein with multiple splicing 2

2

2

High-throughput

0.553

High

1023509

USBP1
Harmonin-binding protein USHBP1

2

2

High-throughput

0.553

High

1023510

CC185
Coiled-coil domain-containing protein 185

2

1

High-throughput

0.553

High

1023513

G45IP
Large ribosomal subunit protein mL64

2

1

High-throughput

0.553

High

1023548

KIFC3
Kinesin-like protein KIFC3

2

1

High-throughput

0.553

High

1023570

GOG6A
Golgin subfamily A member 6A

2

2

High-throughput

0.553

High

1023575

ZIM2
Zinc finger imprinted 2

2

1

High-throughput

0.553

High

1023581

HSF4
Heat shock factor protein 4

2

2

High-throughput

0.553

High

1023589

MAGD1
Melanoma-associated antigen D1

2

3

High-throughput

0.553

High

1023525

SOSB2
SOSS complex subunit B2

1

0

High-throughput

0.549

High

1023590

X5D778
Ankyrin repeat domain 11 isoform A

2

6

High-throughput

0.544

High

962756

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

High-throughput

0.541

High

1023524

RN166
E3 ubiquitin-protein ligase RNF166

1

3

High-throughput

0.541

High

1023553

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

5

High-throughput

0.541

High

201665

MSI1H
RNA-binding protein Musashi homolog 1

1

17

High-throughput

0.536

High

432680

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

16

High-throughput

0.536

High

1023503

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

1

2

High-throughput

0.536

High

1023489

ANR11
Ankyrin repeat domain-containing protein 11

2

4

High-throughput

0.533

High

72139

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

16

High-throughput

0.528

High

311918

SYFM
Phenylalanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.523

High

434578

ERCC1
DNA excision repair protein ERCC-1

1

1

High-throughput

0.523

High

948428

RT06
Small ribosomal subunit protein bS6m

1

1

High-throughput

0.523

High

1023533

RBM41
RNA-binding protein 41

1

19

High-throughput

0.523

High

1023536

ODAD4
Outer dynein arm-docking complex subunit 4

1

1

High-throughput

0.523

High

238607

PEX10
Peroxisome biogenesis factor 10

1

0

High-throughput

0.518

High

1023490

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

0

High-throughput

0.518

High

1023558

RNF32
RING finger protein 32

1

0

High-throughput

0.518

High

1023577

RBX2
RING-box protein 2

1

0

High-throughput

0.518

High

1023455

TADBP
TAR DNA-binding protein 43

1

14

High-throughput

0.515

High

275191

GRAP2
GRB2-related adapter protein 2

1

1

High-throughput

0.512

High

1015749

KIF1A
Kinesin-like protein KIF1A

1

1

High-throughput

0.494

High

1023517

RSPH1
Radial spoke head 1 homolog

1

1

High-throughput

0.494

High

1023537

MIA2
Melanoma inhibitory activity protein 2

1

2

High-throughput

0.489

High

230349

ZC3H1
Zinc finger C3H1 domain-containing protein

1

3

High-throughput

0.481

High

268979

CSDE1
Cold shock domain-containing protein E1

1

1

High-throughput

0.479

High

577629

SON
Protein SON

1

2

High-throughput

0.479

High

962045

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

4

Small-scale

0.479

High

1023487

LARP1
La-related protein 1

1

11

High-throughput

0.479

High

1023496

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

1023497

PABP2
Polyadenylate-binding protein 2

1

17

High-throughput

0.479

High

1023540

ATX2
Ataxin-2

1

3

High-throughput

0.479

High

1023571

BCLF1
Bcl-2-associated transcription factor 1

1

4

High-throughput

0.479

High

1023574

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

9

Small-scale

0.479

High

1023585

TR150
Thyroid hormone receptor-associated protein 3

1

5

High-throughput

0.479

High

1023587

STRAP
Serine-threonine kinase receptor-associated protein

1

1

High-throughput

0.479

High

102381

G3V1X1
Proline/serine-rich coiled-coil 2, isoform CRA_a

1

3

High-throughput

0.470

High

1012166

Q0VAL7
C21orf58 protein

1

1

High-throughput

0.470

High

1023493

NKAP1
Uncharacterized protein NKAPD1

1

2

High-throughput

0.464

High

898008

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.460

High

1023504

ZNF34
Zinc finger protein 34

1

0

High-throughput

0.460

High

3397

A0A0S2Z5X4
Zinc finger protein 688 isoform 4

1

3

High-throughput

0.457

High

837956

MEOX2
Homeobox protein MOX-2

1

5

High-throughput

0.439

High

840243

PEX5
Peroxisomal targeting signal 1 receptor

1

1

High-throughput

0.439

High

885745

CU058
Uncharacterized protein C21orf58

1

1

High-throughput

0.439

High

1023569

NDE1
Nuclear distribution protein nudE homolog 1

1

3

High-throughput

0.439

High

969662

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.437

High

1023500

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

2

High-throughput

0.437

High

1023588

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

1023591

X5DP35
NudE neurodevelopment protein 1 isoform A

1

3

High-throughput

0.417

High

328541

MBD3
Methyl-CpG-binding domain protein 3

3

0

Small-scale

0.354

High

637401

PSA1
Proteasome subunit alpha type-1

3

0

High-throughput

0.352

High

1023542

F110A
Protein FAM110A

3

0

High-throughput

0.352

High

169840

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

3

0

High-throughput

0.350

High

993409

TLE5
TLE family member 5

3

0

High-throughput

0.350

High

684007

1433S
14-3-3 protein sigma

2

0

High-throughput

0.339

High

1023559

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.334

High

67057

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

68632

CMA1B
Ciliary microtubule associated protein 1B

2

0

High-throughput

0.316

High

156141

TSN4
Tetraspanin-4

2

0

High-throughput

0.316

High

206743

B2L11
Bcl-2-like protein 11

2

0

High-throughput

0.316

High

252999

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.316

High

329030

TCL1B
T-cell leukemia/lymphoma protein 1B

2

0

High-throughput

0.316

High

351598

COLI
Pro-opiomelanocortin

2

0

High-throughput

0.316

High

372861

SLPI
Antileukoproteinase

2

0

High-throughput

0.316

High

392958

IGF1
Insulin-like growth factor I

2

0

High-throughput

0.316

High

474597

PRR35
Proline-rich protein 35

2

0

High-throughput

0.316

High

554442

GATA1
Erythroid transcription factor

2

0

High-throughput

0.316

High

568455

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

2

0

High-throughput

0.316

High

578808

ADA2C
Alpha-2C adrenergic receptor

2

0

High-throughput

0.316

High

594517

PSB1
Proteasome subunit beta type-1

2

0

High-throughput

0.316

High

670328

AQP1
Aquaporin-1

2

0

High-throughput

0.316

High

874275

GEM
GTP-binding protein GEM

2

0

High-throughput

0.316

High

887273

MCCD1
Mitochondrial coiled-coil domain protein 1

2

0

High-throughput

0.316

High

976327

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

2

0

High-throughput

0.316

High

978168

ARI5A
AT-rich interactive domain-containing protein 5A

2

0

High-throughput

0.316

High

1023460

LAGE3
EKC/KEOPS complex subunit LAGE3

2

0

High-throughput

0.316

High

1023466

PKN1
Serine/threonine-protein kinase N1

2

0

High-throughput

0.316

High

1023467

ECM1
Extracellular matrix protein 1

2

0

High-throughput

0.316

High

1023469

KLH38
Kelch-like protein 38

2

0

High-throughput

0.316

High

1023470

KR192
Keratin-associated protein 19-2

2

0

High-throughput

0.316

High

1023471

KR212
Keratin-associated protein 21-2

2

0

High-throughput

0.316

High

1023472

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

1023473

KR196
Keratin-associated protein 19-6

2

0

High-throughput

0.316

High

1023474

T10IP
Testis-specific protein 10-interacting protein

2

0

High-throughput

0.316

High

1023475

KR197
Keratin-associated protein 19-7

2

0

High-throughput

0.316

High

1023477

GT253
Inactive glycosyltransferase 25 family member 3

2

0

High-throughput

0.316

High

1023478

AVPI1
Arginine vasopressin-induced protein 1

2

0

High-throughput

0.316

High

1023481

TTC23
Tetratricopeptide repeat protein 23

2

0

High-throughput

0.316

High

1023486

TXD11
Thioredoxin domain-containing protein 11

2

0

High-throughput

0.316

High

1023488

SPAT8
Spermatogenesis-associated protein 8

2

0

High-throughput

0.316

High

1023491

ATL4
ADAMTS-like protein 4

2

0

High-throughput

0.316

High

1023494

ATOSB
Atos homolog protein B

2

0

High-throughput

0.316

High

1023498

KRA81
Keratin-associated protein 8-1

2

0

High-throughput

0.316

High

1023499

KRA71
Keratin-associated protein 7-1

2

0

High-throughput

0.316

High

1023501

Q8IVT4
Hypothetical MGC50722

2

0

High-throughput

0.316

High

1023502

STH
Saitohin

2

0

High-throughput

0.316

High

1023506

BATF2
Basic leucine zipper transcriptional factor ATF-like 2

2

0

High-throughput

0.316

High

1023507

RIBC1
RIB43A-like with coiled-coils protein 1

2

0

High-throughput

0.316

High

1023511

TPRX1
Tetra-peptide repeat homeobox protein 1

2

0

High-throughput

0.316

High

1023512

CEP70
Centrosomal protein of 70 kDa

2

0

High-throughput

0.316

High

1023514

SMIP5
Sperm-associated microtubule inner protein 5

2

0

High-throughput

0.316

High

1023516

ACO11
Acyl-coenzyme A thioesterase 11

2

0

High-throughput

0.316

High

1023527

ARMC5
Armadillo repeat-containing protein 5

2

0

High-throughput

0.316

High

1023528

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.316

High

1023529

RM38
Large ribosomal subunit protein mL38

2

0

High-throughput

0.316

High

1023530

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

0

High-throughput

0.316

High

1023531

CC120
Coiled-coil domain-containing protein 120

2

0

High-throughput

0.316

High

1023538

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

0

High-throughput

0.316

High

1023543

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

2

0

High-throughput

0.316

High

1023544

ANKMT
Adenine nucleotide translocase lysine N-methyltransferase

2

0

High-throughput

0.316

High

1023545

UQCC2
Ubiquinol-cytochrome c reductase complex assembly factor 2

2

0

High-throughput

0.316

High

1023550

CDCA4
Cell division cycle-associated protein 4

2

0

High-throughput

0.316

High

1023560

GO45
Golgin-45

2

0

High-throughput

0.316

High

1023563

STN1
CST complex subunit STN1

2

0

High-throughput

0.316

High

1023566

BPIA1
BPI fold-containing family A member 1

2

0

High-throughput

0.316

High

1023567

MYOZ2
Myozenin-2

2

0

High-throughput

0.316

High

1023572

STMN3
Stathmin-3

2

0

High-throughput

0.316

High

1023573

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.316

High

1023576

TFP11
Tuftelin-interacting protein 11

2

0

High-throughput

0.316

High

1023578

APEX2
DNA-(apurinic or apyrimidinic site) endonuclease 2

2

0

High-throughput

0.316

High

1023582

RASD1
Dexamethasone-induced Ras-related protein 1

2

0

High-throughput

0.316

High

1023583

VP9D1
VPS9 domain-containing protein 1

2

0

High-throughput

0.316

High

403640

AP2A
Transcription factor AP-2-alpha

1

0

High-throughput

0.299

High

1023463

TCEA2
Transcription elongation factor A protein 2

1

0

High-throughput

0.299

High

1023546

EFC4B
EF-hand calcium-binding domain-containing protein 4B

1

0

High-throughput

0.299

High

1023562

F124B
Protein FAM124B

1

0

High-throughput

0.299

High

851243

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.282

High

1023541

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.282

High

1022330

TSN31
Tetraspanin-31

1

0

High-throughput

0.279

Low

47218

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

429523

HEXB
Beta-hexosaminidase subunit beta

1

0

High-throughput

0.268

Low

868162

ATX3
Ataxin-3

1

0

High-throughput

0.268

Low

1023495

PEX26
Peroxisome assembly protein 26

1

0

High-throughput

0.268

Low

1023519

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.268

Low

1023476

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.251

Low

1023505

PRR22
Proline-rich protein 22

1

0

High-throughput

0.251

Low

1023508

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

1023534

SPTCS
Spatacsin

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024