HitPredict

Interactor 1: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8195171
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0008284 - positive regulation of cell population proliferation GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1106 Hs			1 583
+	Hs
		452423 PGFRB_HUMAN (1-1106): 0: 795: 100.00		GRB14_HUMAN (66-579): 1.66e-73: 246: 14.41
+	Hs
		452342 PGFRB_HUMAN (1-1106): 0: 795: 100.00		VAV_HUMAN (163-578): 1.81e-54: 200: 12.25
+	Hs
		452495 PGFRB_HUMAN (1-1106): 0: 795: 100.00		VAV3_HUMAN (190-579): 2.86e-47: 179: 14.52
+	Hs
		208979 PGFRB_HUMAN (1-1106): 0: 795: 100.00		NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83
+	Hs
		452375 PGFRB_HUMAN (1-1106): 0: 795: 100.00		VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97
+	Mm
		404009 PGFRB_MOUSE (1-1106): 0: 801: 85.44		P85A_MOUSE (300-581): 6.66e-38: 151: 15.99
+	Hs
		452344 PGFRB_HUMAN (1-1106): 0: 795: 100.00		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		452361 PGFRB_HUMAN (1-1106): 0: 795: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Mm
		404018 PGFRB_MOUSE (1-1106): 0: 801: 85.44		SH2B1_MOUSE (370-582): 8.38e-34: 139: 24.78
+	Hs
		452424 PGFRB_HUMAN (1-1106): 0: 795: 100.00		GRB7_HUMAN (371-563): 3.91e-33: 135: 21.57
+	Hs
		129176 PGFRB_HUMAN (1-1106): 0: 795: 100.00		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Mm
		404013 PGFRB_MOUSE (1-1106): 0: 801: 85.44		GRB2_MOUSE (482-578): 3.54e-15: 76.8: 30.48
+	Hs
		452385 PGFRB_HUMAN (1-1106): 0: 795: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		557041 PGFRA_HUMAN (3-1106): 0: 716: 42.48		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Mm
		643644 PGFRA_MOUSE (3-1106): 0: 710: 41.67		SHB_MOUSE (369-579): 3.37e-41: 157: 20.18
+	Hs
		557215 PGFRA_HUMAN (3-1106): 0: 716: 42.48		P55G_HUMAN (473-581): 3.75e-31: 128: 29.20
+	Hs
		129191 PGFRA_HUMAN (3-1106): 0: 716: 42.48		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		557088 PGFRA_HUMAN (3-1106): 0: 716: 42.48		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Mm
		403530 KIT_MOUSE (24-1004): 0: 603: 31.01		FES_MOUSE (320-581): 3.18e-37: 149: 20.91
+	Mm
		140055 KIT_MOUSE (24-1004): 0: 603: 31.01		P85B_MOUSE (358-581): 2.77e-30: 128: 16.67