HitPredict

Interactor 1: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Interactor 2: GRB14 (Q14449)
Growth factor receptor-bound protein 14 (GRB14 adapter protein)
Gene: GRB14

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	8647858
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1106 Hs			1 540
+	Hs
		452410 PGFRB_HUMAN (1-1106): 0: 795: 100.00		GRB10_HUMAN (5-540): 0: 551: 54.94
+	Hs
		452424 PGFRB_HUMAN (1-1106): 0: 795: 100.00		GRB7_HUMAN (63-540): 5.06e-175: 506: 50.21
+	Hs
		452342 PGFRB_HUMAN (1-1106): 0: 795: 100.00		VAV_HUMAN (100-534): 8.93e-99: 319: 16.35
+	Hs
		452495 PGFRB_HUMAN (1-1106): 0: 795: 100.00		VAV3_HUMAN (102-534): 1.45e-85: 284: 13.03
+	Hs
		452375 PGFRB_HUMAN (1-1106): 0: 795: 100.00		VAV2_HUMAN (113-534): 1.29e-83: 279: 16.40
+	Mm
		404014 PGFRB_MOUSE (1-1106): 0: 801: 85.44		PLCG1_MOUSE (238-540): 6.4e-43: 166: 17.98
+	Hs
		452348 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PLCG1_HUMAN (238-540): 2.64e-43: 167: 17.67
+	Mm
		404012 PGFRB_MOUSE (1-1106): 0: 801: 85.44		FYN_MOUSE (373-537): 7.01e-41: 156: 20.23
+	Hs
		411953 PGFRB_HUMAN (1-1106): 0: 795: 100.00		FYN_HUMAN (376-537): 4.64e-41: 157: 20.59
+	Hs
		433221 PGFRB_HUMAN (1-1106): 0: 795: 100.00		YES_HUMAN (376-538): 4.56e-41: 157: 20.47
+	Mm
		404013 PGFRB_MOUSE (1-1106): 0: 801: 85.44		GRB2_MOUSE (435-523): 7.59e-28: 112: 31.46
+	Hs
		452385 PGFRB_HUMAN (1-1106): 0: 795: 100.00		GRB2_HUMAN (435-523): 6.87e-28: 112: 31.46
+	Hs
		452399 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTN11_HUMAN (428-526): 1.57e-21: 100: 35.78
+	Mm
		404009 PGFRB_MOUSE (1-1106): 0: 801: 85.44		P85A_MOUSE (315-535): 4.26e-19: 93: 14.60
+	Hs
		452361 PGFRB_HUMAN (1-1106): 0: 795: 100.00		P85A_HUMAN (315-535): 1.52e-19: 94.5: 14.60
+	Hs
		557029 PGFRA_HUMAN (3-1106): 0: 716: 42.48		PLCG1_HUMAN (238-540): 2.64e-43: 167: 17.67
+	Hs
		452363 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTN6_HUMAN (421-523): 1.14e-14: 78.7: 26.79
+	Hs
		557088 PGFRA_HUMAN (3-1106): 0: 716: 42.48		GRB2_HUMAN (435-523): 6.87e-28: 112: 31.46
+	Hs
		557099 PGFRA_HUMAN (3-1106): 0: 716: 42.48		PTN11_HUMAN (428-526): 1.57e-21: 100: 35.78
+	Hs
		557041 PGFRA_HUMAN (3-1106): 0: 716: 42.48		P85A_HUMAN (315-535): 1.52e-19: 94.5: 14.60