HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	35271311, 34079125, 22446626
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016020 - membrane and 1 others more... GO:1990904 - ribonucleoprotein complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 551
+	Hs
		162062 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		609888 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		852074 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		453478 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		846991 RA1L2_HUMAN (1-302): 4.03e-58: 193: 83.44		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		609957 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		609764 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		453331 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		162035 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		453107 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		161948 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516358 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516424 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		1104153 RA1L2_HUMAN (1-302): 4.03e-58: 193: 83.44		TGO1_HUMAN (138-380): 8.27e-13: 73.8: 25.18
+	Hs
		453598 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Hs
		516689 PABP3_HUMAN (6-193): 6.86e-35: 137: 17.90		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516663 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		1020249 ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Sc
		376562 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96
+	Hs
		516484 ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40