Protein: PDI
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Thioredoxin-related glycoprotein 1)

Gene: PDI, PDI1
Organism: Saccharomyces cerevisiae S288C
Interactions: 154
UniProt ID: P17967

Gene Ontology (top 5):
GO:0003756 - protein disulfide isomerase activity
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0006457 - protein folding
GO:0009986 - cell surface

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

572720

PDI
Protein disulfide-isomerase

2

16

Small-scale

0.836

High

572779

MNL1
ER degradation-enhancing alpha-mannosidase-like protein 1

7

12

Small-scale

0.746

High

572821

ERO1
Endoplasmic oxidoreductin-1

6

13

Small-scale

0.726

High

490268

HSP71
Heat shock protein SSA1

3

5

High-throughput

0.633

High

572732

SCJ1
DnaJ-related protein SCJ1

1

1

High-throughput

0.618

High

572750

EUG1
Protein disulfide-isomerase EUG1

1

17

High-throughput

0.618

High

572792

EPS1
ER-retained PMA1-suppressing protein 1

1

17

High-throughput

0.618

High

572839

MPD1
Protein disulfide-isomerase MPD1

1

17

High-throughput

0.618

High

572843

MPD2
Protein disulfide isomerase MPD2

1

1

High-throughput

0.618

High

572746

HS104
Heat shock protein 104

3

0

Small-scale

0.606

High

341081

CBPY
Carboxypeptidase Y

2

3

Small-scale

0.584

High

572793

SGN1
RNA-binding protein SGN1

1

0

High-throughput

0.578

High

572784

RSP5
E3 ubiquitin-protein ligase RSP5

2

8

High-throughput

0.543

High

542657

TAL1
Transaldolase

2

1

High-throughput

0.526

High

446109

MYO1
Myosin-1

1

2

Small-scale

0.504

High

572722

FKBP
FK506-binding protein 1

1

7

High-throughput

0.500

High

340948

PPA5
Repressible acid phosphatase

1

6

High-throughput

0.489

High

549946

CSK21
Casein kinase II subunit alpha

1

7

High-throughput

0.489

High

572724

MDHC
Malate dehydrogenase, cytoplasmic

1

4

High-throughput

0.489

High

572824

TDA1
Serine/threonine-protein kinase TDA1

1

5

High-throughput

0.489

High

572788

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

0

High-throughput

0.480

High

425180

CARP
Saccharopepsin

1

5

High-throughput

0.479

High

543146

HSC82
ATP-dependent molecular chaperone HSC82

1

6

High-throughput

0.479

High

549642

BGL2
Glucan 1,3-beta-glucosidase

1

7

High-throughput

0.479

High

560551

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

572723

KRE5
Killer toxin-resistance protein 5

1

7

High-throughput

0.479

High

572729

CYPB
Peptidyl-prolyl cis-trans isomerase B

1

10

High-throughput

0.479

High

572730

EXG1
Glucan 1,3-beta-glucosidase I/II

1

1

High-throughput

0.479

High

572731

PPA3
Constitutive acid phosphatase

1

6

High-throughput

0.479

High

572740

CHIT
Endochitinase

1

1

High-throughput

0.479

High

572745

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

2

Small-scale

0.479

High

572749

FKBP2
Peptidyl-prolyl cis-trans isomerase FPR2

1

8

High-throughput

0.479

High

572751

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.479

High

572755

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

2

Small-scale

0.479

High

572756

CYPD
Peptidyl-prolyl cis-trans isomerase D

1

9

High-throughput

0.479

High

572761

LHS1
Heat shock protein 70 homolog LHS1

1

11

High-throughput

0.479

High

572763

DCW1
Mannan endo-1,6-alpha-mannosidase DCW1

1

1

High-throughput

0.479

High

572764

UTH1
Probable secreted beta-glucosidase UTH1

1

4

High-throughput

0.479

High

572768

GLU2A
Glucosidase 2 subunit alpha

1

5

High-throughput

0.479

High

572769

ECM33
Cell wall protein ECM33

1

1

High-throughput

0.479

High

572777

GPI16
GPI transamidase component GPI16

1

1

High-throughput

0.479

High

572780

CH10
10 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

572781

PLB1
Lysophospholipase 1

1

2

High-throughput

0.479

High

572785

YEH8
Uncharacterized protein YEL068C

1

1

High-throughput

0.479

High

572790

SIM1
Probable secreted beta-glucosidase SIM1

1

4

High-throughput

0.479

High

572795

MID1
Stretch-activated cation channel MID1

1

1

High-throughput

0.479

High

572798

YFI8
Uncharacterized protein YFR018C

1

1

High-throughput

0.479

High

572800

TOH1
Probable circularly permuted 1,3-beta-glucanase YJL171C

1

3

High-throughput

0.479

High

572801

CIS3
Cell wall mannoprotein CIS3

1

1

High-throughput

0.479

High

572810

SCW4
Probable family 17 glucosidase SCW4

1

5

High-throughput

0.479

High

572811

SUN4
Probable secreted beta-glucosidase SUN4

1

4

High-throughput

0.479

High

572816

TMEDA
Endoplasmic reticulum vesicle protein 25

1

5

High-throughput

0.479

High

572826

PLB2
Lysophospholipase 2

1

2

High-throughput

0.479

High

572830

GLU2B
Glucosidase 2 subunit beta

1

3

High-throughput

0.479

High

572831

SCW10
Probable family 17 glucosidase SCW10

1

5

High-throughput

0.479

High

572832

DFG5
Mannan endo-1,6-alpha-mannosidase DFG5

1

1

High-throughput

0.479

High

572833

GAS5
1,3-beta-glucanosyltransferase GAS5

1

5

High-throughput

0.479

High

572834

SIL1
Nucleotide exchange factor SIL1

1

1

High-throughput

0.479

High

572836

PER33
Pore and endoplasmic reticulum protein of 33 kDa

1

1

Small-scale

0.479

High

572837

POM33
Pore membrane protein of 33 kDa

1

1

Small-scale

0.479

High

572842

OS9
Protein OS-9 homolog

1

1

High-throughput

0.479

High

572733

ADP1
Probable ATP-dependent permease

1

0

High-throughput

0.458

High

572762

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.458

High

572797

FET5
Iron transport multicopper oxidase FET5

1

0

High-throughput

0.458

High

572804

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.458

High

572808

VPS62
Vacuolar protein sorting-associated protein 62

1

0

High-throughput

0.458

High

539298

KSS1
Mitogen-activated protein kinase KSS1

1

4

High-throughput

0.457

High

572734

SSK22
Serine/threonine-protein kinase SSK22

1

3

High-throughput

0.457

High

572759

NNK1
Nitrogen network kinase 1

1

2

High-throughput

0.457

High

572774

KSP1
Serine/threonine-protein kinase KSP1

1

4

High-throughput

0.457

High

572819

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

5

High-throughput

0.457

High

572721

PRP6
Pre-mRNA-splicing factor 6

1

4

High-throughput

0.457

High

572783

RV167
Reduced viability upon starvation protein 167

1

3

High-throughput

0.457

High

572822

YMZ2
WD repeat-containing protein YMR102C

1

11

High-throughput

0.457

High

572841

AP2M
AP-2 complex subunit mu

1

1

High-throughput

0.457

High

449897

HSP73
Heat shock protein SSA3

1

5

High-throughput

0.445

High

510186

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.445

High

572775

SSZ1
Ribosome-associated complex subunit SSZ1

1

5

High-throughput

0.445

High

572786

HSP7E
Heat shock protein SSC3, mitochondrial

1

19

High-throughput

0.445

High

340608

PGK
Phosphoglycerate kinase

1

2

High-throughput

0.437

High

343526

PMG1
Phosphoglycerate mutase 1

1

5

High-throughput

0.437

High

393515

PMA1
Plasma membrane ATPase 1

1

1

High-throughput

0.437

High

410895

PDC1
Pyruvate decarboxylase isozyme 1

1

1

High-throughput

0.437

High

424990

DHE4
NADP-specific glutamate dehydrogenase 1

1

1

High-throughput

0.437

High

448480

PRTB
Cerevisin

1

3

High-throughput

0.437

High

520059

BAR1
Barrierpepsin

1

5

High-throughput

0.437

High

520906

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.437

High

566518

VATA
V-type proton ATPase catalytic subunit A

1

3

High-throughput

0.437

High

572725

CLH
Clathrin heavy chain

1

1

High-throughput

0.437

High

572726

GAS1
1,3-beta-glucanosyltransferase GAS1

1

5

High-throughput

0.437

High

572728

RAD53
Serine/threonine-protein kinase RAD53

1

2

High-throughput

0.437

High

572735

YCE9
Uncharacterized protein YCL049C

1

1

High-throughput

0.437

High

572738

KRE2
Glycolipid 2-alpha-mannosyltransferase

1

6

High-throughput

0.437

High

572739

KTR1
Alpha-1,2 mannosyltransferase KTR1

1

6

High-throughput

0.437

High

572741

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

572742

TF3B
Transcription factor IIIB 70 kDa subunit

1

2

High-throughput

0.437

High

572743

BMH1
Protein BMH1

1

3

High-throughput

0.437

High

572747

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

2

High-throughput

0.437

High

572753

CRH2
Probable glycosidase CRH2

1

2

High-throughput

0.437

High

572754

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.437

High

572757

DEF1
RNA polymerase II degradation factor 1

1

3

High-throughput

0.437

High

572758

PPAB
Acid phosphatase PHO11

1

6

High-throughput

0.437

High

572760

CENPA
Histone H3-like centromeric protein CSE4

1

3

High-throughput

0.437

High

572765

APE3
Aminopeptidase Y

1

1

High-throughput

0.437

High

572766

ATG42
Vacuolar serine-type carboxypeptidase ATG42

1

3

High-throughput

0.437

High

572767

KTR3
Probable mannosyltransferase KTR3

1

6

High-throughput

0.437

High

572771

TOS1
Probable circularly permuted 1,3-beta-glucanase TOS1

1

3

High-throughput

0.437

High

572772

YPT31
GTP-binding protein YPT31/YPT8

1

1

High-throughput

0.437

High

572773

YGP1
Protein YGP1

1

1

High-throughput

0.437

High

572776

ECM14
Inactive metallocarboxypeptidase ECM14

1

2

High-throughput

0.437

High

572778

YH02
Uncharacterized protein YHR202W

1

1

High-throughput

0.437

High

572791

KTR7
Probable mannosyltransferase KTR7

1

6

High-throughput

0.437

High

572794

GPX3
Glutathione peroxidase-like peroxiredoxin HYR1

1

3

Small-scale

0.437

High

572802

YJN2
Uncharacterized protein YJL132W

1

1

High-throughput

0.437

High

572806

CWH41
Mannosyl-oligosaccharide glucosidase

1

2

High-throughput

0.437

High

572809

CRH1
Probable glycosidase CRH1

1

2

High-throughput

0.437

High

572812

YN95
Uncharacterized membrane glycoprotein YNR066C

1

2

High-throughput

0.437

High

572813

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.437

High

572818

RNY1
Ribonuclease T2-like

1

1

High-throughput

0.437

High

572823

TOM1
E3 ubiquitin-protein ligase TOM1

1

8

High-throughput

0.437

High

572825

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

5

High-throughput

0.437

High

572828

GIS1
Transcriptional activator/repressor GIS1

1

5

High-throughput

0.437

High

572829

YD415
Probable aminopeptidase YDR415C

1

1

High-throughput

0.437

High

572838

SLP1
Uncharacterized protein SLP1

1

1

High-throughput

0.437

High

572817

2ABA
Protein phosphatase PP2A regulatory subunit B

2

0

High-throughput

0.322

High

566121

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.279

Low

572748

CDC11
Cell division control protein 11

1

0

High-throughput

0.279

Low

507787

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase

1

0

High-throughput

0.269

Low

572744

PSK1
Serine/threonine-protein kinase PSK1

1

0

High-throughput

0.261

Low

572796

BNI1
Protein BNI1

1

0

High-throughput

0.261

Low

572799

TOS3
Serine/threonine-protein kinase TOS3

1

0

High-throughput

0.261

Low

572827

ENT5
Epsin-5

1

0

Small-scale

0.261

Low

375261

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.249

Low

389217

HXKA
Hexokinase-1

1

0

High-throughput

0.249

Low

402877

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

0

Small-scale

0.249

Low

421747

KAD2
Adenylate kinase

1

0

High-throughput

0.249

Low

537347

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.249

Low

572727

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.249

Low

572736

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.249

Low

572737

CBPS
Carboxypeptidase S

1

0

High-throughput

0.249

Low

572752

GDA1
Guanosine-diphosphatase

1

0

High-throughput

0.249

Low

572770

GID4
Vacuolar import and degradation protein 24

1

0

High-throughput

0.249

Low

572782

MNN1
Alpha-1,3-mannosyltransferase MNN1

1

0

High-throughput

0.249

Low

572803

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

572805

HGH1
Protein HGH1

1

0

Small-scale

0.249

Low

572807

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.249

Low

572814

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

572815

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.249

Low

572820

COFI
Cofilin

1

0

High-throughput

0.249

Low

572835

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

0

High-throughput

0.249

Low

572840

NPC2
Phosphatidylglycerol/phosphatidylinositol transfer protein

1

0

High-throughput

0.249

Low

572787

YE19
Uncharacterized protein YER189W

1

0

High-throughput

0.238

Low

572789

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024