HitPredict

Interactor 1: UCHL1 (P09936)
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)
Gene: UCHL1

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	23717208, 32814053, 17353931
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, anti bait coimmunoprecipitation, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 223 Hs			1 522
+	Hs
		456637 UCHL1_HUMAN (1-223): 2.52e-103: 299: 100.00		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		456560 UCHL1_HUMAN (1-223): 2.52e-103: 299: 100.00		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		456497 UCHL1_HUMAN (1-223): 2.52e-103: 299: 100.00		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		537150 UCHL5_HUMAN (2-220): 2.67e-99: 293: 21.68		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		536719 UCHL3_HUMAN (2-222): 2.74e-100: 292: 54.43		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		585024 BAP1_HUMAN (3-220): 2.36e-78: 250: 22.27		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97