HitPredict

Interactor 1: RHOC (P08134)
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Gene: RHOC

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 216
+	Hs
		962071 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		RAB35_HUMAN (1-188): 1.33e-82: 245: 29.47
+	Hs
		988382 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		RAB35_HUMAN (1-188): 1.33e-82: 245: 29.47
+	Hs
		961930 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		RAB1A_HUMAN (1-196): 2.37e-81: 242: 28.00
+	Hs
		981255 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		RAB1A_HUMAN (1-196): 2.37e-81: 242: 28.00
+	Hs
		466193 RHOC_HUMAN (1-193): 7.6e-80: 237: 100.00		RAB1A_HUMAN (1-196): 2.37e-81: 242: 28.00
+	Hs
		962463 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		RAB1B_HUMAN (4-195): 2.99e-80: 239: 28.72
+	Hs
		988691 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		RAB1B_HUMAN (4-195): 2.99e-80: 239: 28.72
+	Hs
		981448 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		RAN_HUMAN (1-216): 1.48e-79: 238: 100.00
+	Hs
		466451 RHOC_HUMAN (1-193): 7.6e-80: 237: 100.00		RAB1B_HUMAN (4-195): 2.99e-80: 239: 28.72
+	Hs
		955905 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		RAB8A_HUMAN (1-203): 9.08e-79: 236: 24.76
+	Hs
		955911 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		RAB8A_HUMAN (1-203): 9.08e-79: 236: 24.76
+	Hs
		976191 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		RB11A_HUMAN (4-208): 4.29e-78: 235: 26.67
+	Hs
		981257 RHOG_HUMAN (1-193): 2.26e-78: 233: 54.92		RAB1A_HUMAN (1-196): 2.37e-81: 242: 28.00
+	Hs
		466179 RHOC_HUMAN (1-193): 7.6e-80: 237: 100.00		RAB8A_HUMAN (1-203): 9.08e-79: 236: 24.76
+	Hs
		955915 RHOG_HUMAN (1-193): 2.26e-78: 233: 54.92		RAB8A_HUMAN (1-203): 9.08e-79: 236: 24.76
+	Hs
		901166 RHOA_HUMAN (1-193): 4.28e-81: 240: 91.71		RAB7A_HUMAN (8-166): 7.47e-29: 108: 33.13
+	Hs
		901174 RAC1_HUMAN (1-193): 6.84e-81: 240: 57.22		RAB7A_HUMAN (8-166): 7.47e-29: 108: 33.13
+	Hs
		466158 RHOC_HUMAN (1-193): 7.6e-80: 237: 100.00		RAB7A_HUMAN (8-166): 7.47e-29: 108: 33.13
+	Hs
		901184 RHOG_HUMAN (1-193): 2.26e-78: 233: 54.92		RAB7A_HUMAN (8-166): 7.47e-29: 108: 33.13
+	Hs
		630745 CDC42_HUMAN (1-193): 8.86e-78: 232: 51.30		RAB4A_HUMAN (11-169): 1.54e-27: 105: 34.57