Interactor 1: COABC (P0ABQ0)
Coenzyme A biosynthesis bifunctional protein CoaBC (DNA/pantothenate metabolism flavoprotein) (Phosphopantothenoylcysteine synthetase/decarboxylase) (PPCS-PPCDC) [Includes: Phosphopantothenoylcysteine decarboxylase (PPC decarboxylase) (PPC-DC) (EC 4.1.1.36) (CoaC); Phosphopantothenate--cysteine ligase (EC 6.3.2.5) (CoaB) (Phosphopantothenoylcysteine synthetase) (PPC synthetase) (PPC-S)]
Gene: COABC

Interactor 2: COABC (P0ABQ0)
Coenzyme A biosynthesis bifunctional protein CoaBC (DNA/pantothenate metabolism flavoprotein) (Phosphopantothenoylcysteine synthetase/decarboxylase) (PPCS-PPCDC) [Includes: Phosphopantothenoylcysteine decarboxylase (PPC decarboxylase) (PPC-DC) (EC 4.1.1.36) (CoaC); Phosphopantothenate--cysteine ligase (EC 6.3.2.5) (CoaB) (Phosphopantothenoylcysteine synthetase) (PPC synthetase) (PPC-S)]
Gene: COABC

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.647

The method score is based on:

Property Details
Experiments 15530362
Identification Methods x-ray crystallography
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains DFP~DFP, DFP~Flavoprotein, Flavoprotein~Flavoprotein
Common GO terms GO:0004632 - phosphopantothenate--cysteine ligase activity
GO:0004633 - phosphopantothenoylcysteine decarboxylase activity
GO:0005829 - cytosol
GO:0010181 - FMN binding
GO:0015937 - coenzyme A biosynthetic process
and 3 others

more...

Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 406
Ec

1 406
+ At
+ At
+ Hs
+ Dm
+ Sp
+ Sc
+ Ce
+ Sc
+ Sc
+ Sc
+ Sc
+ Sc

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Last updated: 15 Jul 2024