HitPredict

Interactor 1: CRP (P0ACJ8)
DNA-binding transcriptional dual regulator CRP (Catabolite activator protein) (CAP) (Catabolite gene activator) (cAMP receptor protein) (CRP) (cAMP regulatory protein) (cAMP-activated global transcriptional regulator CRP)
Gene: CRP

Interactor 2: CRP (P0ACJ8)
DNA-binding transcriptional dual regulator CRP (Catabolite activator protein) (CAP) (Catabolite gene activator) (cAMP receptor protein) (CRP) (cAMP regulatory protein) (cAMP-activated global transcriptional regulator CRP)
Gene: CRP

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.896

The method score is based on:

Property Details
Experiments 16906160, 19359484, 19805344, 23644478
Identification Methods nuclear magnetic resonance, molecular sieving, x-ray crystallography
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains cNMP_binding~cNMP_binding, HTH_Crp_2~cNMP_binding, HTH_Crp_2~HTH_Crp_2
Common GO terms GO:0003680 - minor groove of adenine-thymine-rich DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0005829 - cytosol
GO:0006351 - DNA-templated transcription
GO:0008301 - DNA binding, bending
and 6 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 210
Ec

1 210
+ Pa
+ Ce
+ Se
+ Ns
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs

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Last updated: 15 Jul 2024