Protein: MDR1
ATP-dependent translocase ABCB1 (ATP-binding cassette sub-family B member 1) (Multidrug resistance protein 1) (EC 7.6.2.2) (P-glycoprotein 1) (Phospholipid transporter ABCB1) (EC 7.6.2.1) (CD antigen CD243)

Gene: MDR1, ABCB1
Organism: Homo sapiens
Interactions: 103
UniProt ID: P08183

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0001666 - response to hypoxia
GO:0001890 - placenta development
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

467227

PIM1
Serine/threonine-protein kinase pim-1

1

0

Small-scale

0.708

High

467231

LEG3
Galectin-3

4

10

High-throughput

0.691

High

467232

MDR3
Phosphatidylcholine translocator ABCB4

1

6

High-throughput

0.618

High

467243

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.618

High

467262

ABCB5
ATP-binding cassette sub-family B member 5

1

6

High-throughput

0.618

High

467301

ABCB9
ABC-type oligopeptide transporter ABCB9

1

7

High-throughput

0.618

High

467248

RB11A
Ras-related protein Rab-11A

2

1

High-throughput

0.611

High

467288

TM169
Transmembrane protein 169

2

1

High-throughput

0.601

High

467286

SAAL1
Protein SAAL1

2

2

High-throughput

0.549

High

467234

CALX
Calnexin

1

2

High-throughput

0.536

High

467245

CCR6
C-C chemokine receptor type 6

1

11

High-throughput

0.536

High

467265

TTMP
TPA-induced transmembrane protein

1

2

High-throughput

0.536

High

467283

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

2

High-throughput

0.536

High

467299

TTYH1
Protein tweety homolog 1

1

2

High-throughput

0.536

High

467308

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

2

High-throughput

0.536

High

378813

CD4
T-cell surface glycoprotein CD4

1

0

High-throughput

0.518

High

467293

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.518

High

467226

BCL2
Apoptosis regulator Bcl-2

1

0

High-throughput

0.513

High

467247

T2R19
Taste receptor type 2 member 19

1

0

High-throughput

0.513

High

467279

ARRD4
Arrestin domain-containing protein 4

1

0

High-throughput

0.513

High

467290

RING2
E3 ubiquitin-protein ligase RING2

1

1

Small-scale

0.506

High

464764

SP1
Transcription factor Sp1

1

1

Small-scale

0.501

High

276266

HMMR
Hyaluronan mediated motility receptor

1

0

High-throughput

0.493

High

467263

LEG9B
Galectin-9B

1

10

High-throughput

0.489

High

467229

CD44
CD44 antigen

1

1

Small-scale

0.481

High

467235

PSB8
Proteasome subunit beta type-8

1

1

Small-scale

0.481

High

467282

LNX1
E3 ubiquitin-protein ligase LNX

1

2

Small-scale

0.481

High

467241

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

Small-scale

0.480

High

125156

LEG9
Galectin-9

1

10

High-throughput

0.479

High

375100

RASK
GTPase KRas

1

8

High-throughput

0.479

High

411209

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

467224

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

6

Small-scale

0.479

High

467225

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

High-throughput

0.479

High

467230

RHOQ
Rho-related GTP-binding protein RhoQ

1

12

High-throughput

0.479

High

467242

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

467244

RAB5C
Ras-related protein Rab-5C

1

3

High-throughput

0.479

High

467250

CAV1
Caveolin-1

1

2

Small-scale

0.479

High

467255

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

1

2

High-throughput

0.479

High

467260

VAMP3
Vesicle-associated membrane protein 3

1

1

High-throughput

0.479

High

467266

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

2

Small-scale

0.479

High

467270

RHOU
Rho-related GTP-binding protein RhoU

1

16

High-throughput

0.479

High

467291

PHB2
Prohibitin-2

1

2

High-throughput

0.479

High

467294

CP250
Centrosome-associated protein CEP250

1

1

High-throughput

0.479

High

467310

LAMP3
Lysosome-associated membrane glycoprotein 3

1

3

High-throughput

0.479

High

441404

CHLE
Cholinesterase

1

0

High-throughput

0.458

High

467228

LOX15
Polyunsaturated fatty acid lipoxygenase ALOX15

1

0

High-throughput

0.458

High

467238

UBA7
Ubiquitin-like modifier-activating enzyme 7

1

0

Small-scale

0.458

High

467251

DHX9
ATP-dependent RNA helicase A

1

0

Small-scale

0.458

High

467258

CUL7
Cullin-7

1

0

High-throughput

0.458

High

467264

MIDN
Midnolin

1

0

High-throughput

0.458

High

467273

LAP4B
Lysosomal-associated transmembrane protein 4B

1

0

Small-scale

0.458

High

467287

PGM2
Phosphopentomutase

1

0

High-throughput

0.458

High

467305

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.458

High

467249

SP3
Transcription factor Sp3

1

1

Small-scale

0.457

High

211107

CTR4
Cationic amino acid transporter 4

1

4

High-throughput

0.445

High

279559

LAT3
Large neutral amino acids transporter small subunit 3

1

3

High-throughput

0.445

High

370962

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.445

High

388356

B3AT
Band 3 anion transport protein

1

1

High-throughput

0.445

High

467233

CD9
CD9 antigen

1

3

High-throughput

0.445

High

467236

SC6A1
Sodium- and chloride-dependent GABA transporter 1

1

3

High-throughput

0.445

High

467237

S26A3
Chloride anion exchanger

1

2

High-throughput

0.445

High

467239

S19A1
Reduced folate transporter

1

3

High-throughput

0.445

High

467240

EAA3
Excitatory amino acid transporter 3

1

1

High-throughput

0.445

High

467246

CTR2
Cationic amino acid transporter 2

1

4

High-throughput

0.445

High

467252

NIPA4
Magnesium transporter NIPA4

1

3

High-throughput

0.445

High

467254

TRDN
Triadin

1

5

High-throughput

0.445

High

467257

MFS10
Major facilitator superfamily domain-containing protein 10

1

4

High-throughput

0.445

High

467261

SC5AC
Sodium-coupled monocarboxylate transporter 2

1

1

High-throughput

0.445

High

467267

NPAL3
NIPA-like protein 3

1

3

High-throughput

0.445

High

467268

S39A4
Zinc transporter ZIP4

1

6

High-throughput

0.445

High

467271

S46A3
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3

1

2

High-throughput

0.445

High

467272

SL9B2
Sodium/hydrogen exchanger 9B2

1

1

High-throughput

0.445

High

467274

SL9A9
Sodium/hydrogen exchanger 9

1

1

High-throughput

0.445

High

467276

S43A3
Equilibrative nucleobase transporter 1

1

3

High-throughput

0.445

High

467284

MOT10
Monocarboxylate transporter 10

1

3

High-throughput

0.445

High

467292

SC6A7
Sodium-dependent proline transporter

1

3

High-throughput

0.445

High

467295

S46A2
Solute carrier family 46 member 2

1

3

High-throughput

0.445

High

467296

S19A3
Thiamine transporter 2

1

3

High-throughput

0.445

High

467298

S22A4
Solute carrier family 22 member 4

1

5

High-throughput

0.445

High

467302

SO1B3
Solute carrier organic anion transporter family member 1B3

1

1

High-throughput

0.445

High

467304

RHCG
Ammonium transporter Rh type C

1

2

High-throughput

0.445

High

467307

S6A14
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

1

3

High-throughput

0.445

High

467280

FXL13
F-box and leucine-rich repeat protein 13

1

1

Small-scale

0.437

High

467306

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.437

High

337063

NPT2B
Sodium-dependent phosphate transport protein 2B

1

0

High-throughput

0.426

High

421334

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.426

High

467253

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.426

High

467269

MFSD6
Major facilitator superfamily domain-containing protein 6

1

0

High-throughput

0.426

High

467275

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.426

High

467297

S13A1
Solute carrier family 13 member 1

1

0

High-throughput

0.426

High

467300

POPD2
Popeye domain-containing protein 2

1

0

High-throughput

0.426

High

467309

FLVC2
Choline/ethanolamine transporter FLVCR2

1

0

High-throughput

0.426

High

170628

CLGN
Calmegin

1

2

High-throughput

0.407

High

467281

MFSD8
Major facilitator superfamily domain-containing protein 8

1

1

High-throughput

0.407

High

467285

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.301

High

322571

FBX21
F-box only protein 21

1

0

Small-scale

0.292

High

467303

BCCIP
BRCA2 and CDKN1A-interacting protein

1

0

High-throughput

0.282

High

467259

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

Small-scale

0.251

Low

467256

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.249

Low

467278

FBX15
F-box only protein 15

1

0

Small-scale

0.249

Low

467289

VP13A
Intermembrane lipid transfer protein VPS13A

1

0

High-throughput

0.249

Low

467277

S38A9
Neutral amino acid transporter 9

1

0

High-throughput

0.232

Low

467311

WASC3
WASH complex subunit 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025