HitPredict

Interactor 1: ENVZ (P0AEJ4)
Sensor histidine kinase EnvZ (EC 2.7.13.3) (Osmolarity sensor protein EnvZ)
Gene: ENVZ

Interactor 2: ENVZ (P0AEJ4)
Sensor histidine kinase EnvZ (EC 2.7.13.3) (Osmolarity sensor protein EnvZ)
Gene: ENVZ

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 1.00 0.835

The method score is based on:

Property Details
Experiments 10426948, 19432797, 22543870
Identification Methods nuclear magnetic resonance, adenylate cyclase complementation, protein kinase assay
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains HAMP~HAMP, HAMP~HATPase_c, HAMP~HisKA, HATPase_c~HATPase_c, HATPase_c~HisKA, HisKA~HisKA
Common GO terms GO:0000155 - phosphorelay sensor kinase activity
GO:0000160 - phosphorelay signal transduction system
GO:0004721 - phosphoprotein phosphatase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
and 7 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 450
Ec

1 450
+ At
+ At
+ At
+ At
+ At
+ Tm
+ Ec
+ Mt
+ Cv
+ Ec
+ Bs
+ Ec
+ Ss
+ Mx
+ Mx
+ Mx
+ Mx

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024