HitPredict

Interactor 1: CO4A (P0C0L4)
Complement C4-A (Acidic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2) [Cleaved into: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain]
Gene: C4A

Interactor 2: MASP1 (P48740)
Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
Gene: MASP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23785123
Identification Methods	solid phase assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	A2M~Sushi, A2M_BRD~Sushi, A2M_recep~Trypsin, MG2~Sushi, MG2~Trypsin, MG4~Sushi, NTR~Sushi, Sushi~TED_complement
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1744 Hs			1 699
+	Hs
		469901 CO4B_HUMAN (1-1744): 0: 2077: 99.43		MASP1_HUMAN (1-699): 0: 659: 100.00
+	Hs
		119683 CO4A_HUMAN (1-1744): 0: 2079: 100.00		MASP2_HUMAN (20-695): 0: 547: 41.61
+	Hs
		119684 CO4B_HUMAN (1-1744): 0: 2077: 99.43		MASP2_HUMAN (20-695): 0: 547: 41.61
+	Hs
		455002 CO4A_HUMAN (1-1744): 0: 2079: 100.00		C1S_HUMAN (1-699): 6.58e-173: 512: 33.70
+	Hs
		455003 CO4B_HUMAN (1-1744): 0: 2077: 99.43		C1S_HUMAN (1-699): 6.58e-173: 512: 33.70
+	Hs
		344649 CO3_HUMAN (20-1742): 0: 1532: 27.81		MASP1_HUMAN (1-699): 0: 659: 100.00
+	Hs
		119680 CO3_HUMAN (20-1742): 0: 1532: 27.81		MASP2_HUMAN (20-695): 0: 547: 41.61