Protein: FANCM
Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog)

Gene: FANCM
Organism: Homo sapiens
Interactions: 72
UniProt ID: Q8IYD8

Gene Ontology (top 5):
GO:0000400 - four-way junction DNA binding
GO:0000712 - resolution of meiotic recombination intermediates
GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0003724 - RNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1314869

FAP24
Fanconi anemia core complex-associated protein 24

12

0

Small-scale

0.935

High

1314862

CENPS
Centromere protein S

8

0

Small-scale

0.923

High

926379

BLM
RecQ-like DNA helicase BLM

5

19

Small-scale

0.915

High

70869

CENPX
Centromere protein X

5

0

Small-scale

0.875

High

1106438

TOP3A
DNA topoisomerase 3-alpha

3

6

Small-scale

0.857

High

187533

FANCA
Fanconi anemia group A protein

12

1

Small-scale

0.756

High

1314861

FANCM
Fanconi anemia group M protein

2

20

Small-scale

0.754

High

1314883

FBW1B
F-box/WD repeat-containing protein 11

2

20

Small-scale

0.754

High

572062

TRI27
Zinc finger protein RFP

1

9

High-throughput

0.740

High

1314878

FANCL
E3 ubiquitin-protein ligase FANCL

10

0

Small-scale

0.718

High

1314875

FANCE
Fanconi anemia group E protein

8

0

Small-scale

0.713

High

185213

FANCG
Fanconi anemia group G protein

5

2

Small-scale

0.709

High

1314876

FANCF
Fanconi anemia group F protein

6

0

Small-scale

0.702

High

1314874

RMI1
RecQ-mediated genome instability protein 1

4

2

Small-scale

0.700

High

1081752

FP100
Fanconi anemia core complex-associated protein 100

6

0

Small-scale

0.695

High

551151

PCNA
Proliferating cell nuclear antigen

3

2

Small-scale

0.681

High

1314863

FANCB
Fanconi anemia group B protein

4

0

Small-scale

0.664

High

1025886

FANCC
Fanconi anemia group C protein

4

0

Small-scale

0.657

High

62402

EME2
Structure-specific endonuclease subunit EME2

1

2

Small-scale

0.647

High

1055941

RAD51
DNA repair protein RAD51 homolog 1

1

8

Small-scale

0.618

High

1314866

EME1
Structure-specific endonuclease subunit EME1

1

2

Small-scale

0.618

High

1314884

INO80
Chromatin-remodeling ATPase INO80

1

16

Small-scale

0.618

High

1314885

FBW1A
F-box/WD repeat-containing protein 1A

1

20

Small-scale

0.618

High

1239768

FAP20
Fanconi anemia core complex-associated protein 20

3

0

Small-scale

0.613

High

329463

EPN2
Epsin-2

2

4

High-throughput

0.606

High

422541

A4
Amyloid-beta precursor protein

2

8

High-throughput

0.602

High

1136098

PAF15
PCNA-associated factor

2

0

High-throughput

0.602

High

888180

MCM2
DNA replication licensing factor MCM2

2

20

Small-scale

0.584

High

1314871

FACD2
Fanconi anemia group D2 protein

2

13

Small-scale

0.584

High

1314867

RMI2
RecQ-mediated genome instability protein 2

2

0

Small-scale

0.569

High

281227

CDC45
Cell division control protein 45 homolog

2

0

Small-scale

0.559

High

355640

MOC2A
Molybdopterin synthase sulfur carrier subunit

2

0

High-throughput

0.559

High

1314886

TELO2
Telomere length regulation protein TEL2 homolog

2

0

Small-scale

0.559

High

1209371

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.536

High

289160

PRDM1
PR domain zinc finger protein 1

1

6

High-throughput

0.536

High

1099723

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

6

High-throughput

0.536

High

1123259

DPYL3
Dihydropyrimidinase-related protein 3

1

1

High-throughput

0.536

High

1314864

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

16

High-throughput

0.536

High

1314865

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

7

High-throughput

0.536

High

1314868

SORT
Sortilin

1

1

High-throughput

0.536

High

1314870

KIFC3
Kinesin-like protein KIFC3

1

1

High-throughput

0.536

High

1314879

CARF
CDKN2A-interacting protein

1

7

High-throughput

0.536

High

354278

MOC2B
Molybdopterin synthase catalytic subunit

2

0

High-throughput

0.528

High

1143187

PLEC
Plectin

1

4

High-throughput

0.515

High

1122217

SPIDR
DNA repair-scaffolding protein

1

0

Small-scale

0.513

High

1314872

CAPAM
mRNA

1

0

High-throughput

0.513

High

993647

UBC9
SUMO-conjugating enzyme UBC9

1

7

Small-scale

0.501

High

457977

TRY1
Serine protease 1

1

5

High-throughput

0.489

High

996761

TBA1B
Tubulin alpha-1B chain

1

10

High-throughput

0.489

High

1010668

DCD
Dermcidin

1

3

High-throughput

0.489

High

1314873

ECT2
Protein ECT2

1

11

High-throughput

0.481

High

290954

PPM1B
Protein phosphatase 1B

1

1

High-throughput

0.479

High

589121

RFA2
Replication protein A 32 kDa subunit

1

16

Small-scale

0.479

High

695905

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

14

Small-scale

0.479

High

755977

MCM5
DNA replication licensing factor MCM5

1

18

Small-scale

0.479

High

775193

FUS
RNA-binding protein FUS

1

20

High-throughput

0.479

High

799283

BRCA1
Breast cancer type 1 susceptibility protein

1

20

High-throughput

0.479

High

889607

CLK2
Dual specificity protein kinase CLK2

1

15

Small-scale

0.479

High

979963

H4
Histone H4

1

16

High-throughput

0.479

High

1091049

FOXF1
Forkhead box protein F1

1

20

Small-scale

0.479

High

1272238

MCM10
Protein MCM10 homolog

1

1

Small-scale

0.479

High

1294913

ZGRF1
5'-3' DNA helicase ZGRF1

1

8

Small-scale

0.479

High

1313250

SMC5
Structural maintenance of chromosomes protein 5

1

15

High-throughput

0.479

High

1314882

MCM8
DNA helicase MCM8

1

20

Small-scale

0.479

High

1314877

FANCI
Fanconi anemia group I protein

1

0

Small-scale

0.458

High

1314880

ETAA1
Ewing's tumor-associated antigen 1

1

0

Small-scale

0.458

High

372535

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.445

High

1115291

CUL4B
Cullin-4B

1

20

Small-scale

0.445

High

1314881

GRHL1
Grainyhead-like protein 1 homolog

1

7

High-throughput

0.445

High

528480

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

2

0

High-throughput

0.313

High

1178808

KIZ
Centrosomal protein kizuna

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025