Protein: RXRA
Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)

Gene: RXRA
Organism: Homo sapiens
Interactions: 141
UniProt ID: P19793

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

587130

PPARG
Peroxisome proliferator-activated receptor gamma

36

20

Small-scale

0.994

High

509900

VDR
Vitamin D3 receptor

27

20

Small-scale

0.992

High

487899

RARA
Retinoic acid receptor alpha

20

17

Small-scale

0.988

High

587177

NCOA1
Nuclear receptor coactivator 1

15

20

Small-scale

0.983

High

500461

THB
Thyroid hormone receptor beta

9

20

Small-scale

0.968

High

587156

PPARA
Peroxisome proliferator-activated receptor alpha

7

20

Small-scale

0.953

High

587173

NCOA2
Nuclear receptor coactivator 2

5

20

Small-scale

0.922

High

587144

NR1H2
Oxysterols receptor LXR-beta

5

20

Small-scale

0.922

High

587153

PPARD
Peroxisome proliferator-activated receptor delta

5

20

Small-scale

0.912

High

587162

NR1H3
Oxysterols receptor LXR-alpha

4

20

Small-scale

0.891

High

587170

NR1I3
Nuclear receptor subfamily 1 group I member 3

4

20

Small-scale

0.888

High

587212

NCOA3
Nuclear receptor coactivator 3

4

20

Small-scale

0.888

High

265850

NR1I2
Nuclear receptor subfamily 1 group I member 2

4

20

Small-scale

0.881

High

500387

THA
Thyroid hormone receptor alpha

4

19

Small-scale

0.875

High

587117

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

3

20

Small-scale

0.856

High

587112

RXRA
Retinoic acid receptor RXR-alpha

3

20

Small-scale

0.840

High

587172

NR0B2
Nuclear receptor subfamily 0 group B member 2

3

19

Small-scale

0.833

High

587194

NR1H4
Bile acid receptor

2

20

Small-scale

0.821

High

587136

RXRG
Retinoic acid receptor RXR-gamma

2

20

High-throughput

0.811

High

587135

NR4A2
Nuclear receptor subfamily 4 group A member 2

2

20

Small-scale

0.786

High

587125

CTNB1
Catenin beta-1

2

17

Small-scale

0.754

High

587169

NCOA6
Nuclear receptor coactivator 6

6

20

Small-scale

0.738

High

587174

MED1
Mediator of RNA polymerase II transcription subunit 1

5

20

Small-scale

0.705

High

587211

NCOR2
Nuclear receptor corepressor 2

5

20

Small-scale

0.702

High

170251

TIF1A
Transcription intermediary factor 1-alpha

3

20

Small-scale

0.655

High

261399

NCOR1
Nuclear receptor corepressor 1

3

20

Small-scale

0.655

High

587209

NR2E3
Photoreceptor-specific nuclear receptor

1

20

Small-scale

0.647

High

587203

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

2

20

Small-scale

0.628

High

437626

MCR
Mineralocorticoid receptor

1

20

High-throughput

0.621

High

490049

NR2F6
Nuclear receptor subfamily 2 group F member 6

1

19

Small-scale

0.621

High

510003

ERR1
Steroid hormone receptor ERR1

1

20

Small-scale

0.621

High

530782

RARG
Retinoic acid receptor gamma

1

17

High-throughput

0.621

High

368969

ESR1
Estrogen receptor

1

19

High-throughput

0.618

High

587128

FUS
RNA-binding protein FUS

2

20

Small-scale

0.611

High

540778

PO2F1
POU domain, class 2, transcription factor 1

2

20

Small-scale

0.602

High

587119

MK03
Mitogen-activated protein kinase 3

2

13

Small-scale

0.602

High

587137

NRIP1
Nuclear receptor-interacting protein 1

2

14

Small-scale

0.602

High

587155

TF65
Transcription factor p65

2

17

Small-scale

0.602

High

146455

BHE40
Class E basic helix-loop-helix protein 40

2

3

Small-scale

0.601

High

587118

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

2

6

Small-scale

0.600

High

434936

SP1
Transcription factor Sp1

2

20

Small-scale

0.595

High

587164

SQSTM
Sequestosome-1

2

8

Small-scale

0.595

High

587150

PRS8
26S proteasome regulatory subunit 8

2

20

Small-scale

0.594

High

587185

MED25
Mediator of RNA polymerase II transcription subunit 25

1

7

Small-scale

0.594

High

587189

ROBO4
Roundabout homolog 4

1

7

Small-scale

0.579

High

500354

RARB
Retinoic acid receptor beta

1

17

Small-scale

0.575

High

587132

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

12

High-throughput

0.573

High

242976

EDF1
Endothelial differentiation-related factor 1

1

2

Small-scale

0.561

High

267618

TADA3
Transcriptional adapter 3

1

4

Small-scale

0.561

High

572495

IBP3
Insulin-like growth factor-binding protein 3

1

2

Small-scale

0.561

High

587168

KLF5
Krueppel-like factor 5

1

20

Small-scale

0.561

High

282522

RNF8
E3 ubiquitin-protein ligase RNF8

1

13

Small-scale

0.549

High

587159

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.541

High

587200

UBQL4
Ubiquilin-4

1

12

High-throughput

0.541

High

63017

CAST2
Cytosolic arginine sensor for mTORC1 subunit 2

1

1

High-throughput

0.536

High

587188

CAST1
Cytosolic arginine sensor for mTORC1 subunit 1

1

1

High-throughput

0.536

High

587202

MIOS
GATOR2 complex protein MIOS

1

12

High-throughput

0.536

High

587120

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

10

Small-scale

0.534

High

181498

CLOCK
Circadian locomoter output cycles protein kaput

1

20

Small-scale

0.527

High

587114

TBP
TATA-box-binding protein

1

3

Small-scale

0.527

High

587116

BCL3
B-cell lymphoma 3 protein

1

20

Small-scale

0.527

High

587163

CENPR
Centromere protein R

1

1

Small-scale

0.527

High

587167

NCOA4
Nuclear receptor coactivator 4

1

1

Small-scale

0.527

High

587175

TRIP4
Activating signal cointegrator 1

1

4

Small-scale

0.527

High

587176

IKBB
NF-kappa-B inhibitor beta

1

15

Small-scale

0.527

High

587195

NPAS2
Neuronal PAS domain-containing protein 2

1

20

Small-scale

0.527

High

587198

BRD8
Bromodomain-containing protein 8

1

20

Small-scale

0.527

High

61306

CNOT1
CCR4-NOT transcription complex subunit 1

1

1

Small-scale

0.508

High

587133

CASP2
Caspase-2

1

3

High-throughput

0.508

High

587139

GSK3B
Glycogen synthase kinase-3 beta

1

6

High-throughput

0.508

High

587143

PLK1
Serine/threonine-protein kinase PLK1

1

9

High-throughput

0.508

High

587152

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.508

High

587154

ARI5A
AT-rich interactive domain-containing protein 5A

1

20

Small-scale

0.508

High

587178

SMAD2
Mothers against decapentaplegic homolog 2

1

10

High-throughput

0.508

High

587179

SMN
Survival motor neuron protein

1

2

High-throughput

0.508

High

587196

KPCD2
Serine/threonine-protein kinase D2

1

10

High-throughput

0.508

High

587205

KS6A6
Ribosomal protein S6 kinase alpha-6

1

13

High-throughput

0.508

High

126103

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

20

Small-scale

0.501

High

177191

HDAC3
Histone deacetylase 3

1

20

Small-scale

0.501

High

265302

MED24
Mediator of RNA polymerase II transcription subunit 24

1

4

Small-scale

0.501

High

309832

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

6

Small-scale

0.501

High

414730

CDK1
Cyclin-dependent kinase 1

1

4

Small-scale

0.501

High

429822

CATL1
Procathepsin L

1

1

Small-scale

0.501

High

447468

PO2F2
POU domain, class 2, transcription factor 2

1

20

Small-scale

0.501

High

522762

SRC
Proto-oncogene tyrosine-protein kinase Src

1

7

Small-scale

0.501

High

545935

MYOD1
Myoblast determination protein 1

1

8

Small-scale

0.501

High

587113

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

20

Small-scale

0.501

High

587121

MK01
Mitogen-activated protein kinase 1

1

13

Small-scale

0.501

High

587122

PML
Protein PML

1

20

Small-scale

0.501

High

587138

CTCF
Transcriptional repressor CTCF

1

10

Small-scale

0.501

High

587147

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.501

High

587151

UBC9
SUMO-conjugating enzyme UBC9

1

5

Small-scale

0.501

High

587165

TDG
G/T mismatch-specific thymine DNA glycosylase

1

2

Small-scale

0.501

High

587166

SNW1
SNW domain-containing protein 1

1

6

Small-scale

0.501

High

587182

TAF1B
TATA box-binding protein-associated factor RNA polymerase I subunit B

1

2

Small-scale

0.501

High

587183

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

2

Small-scale

0.501

High

587184

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

18

Small-scale

0.501

High

587204

DNM3L
DNA

1

6

Small-scale

0.501

High

587206

GRIP1
Glutamate receptor-interacting protein 1

1

16

Small-scale

0.501

High

587207

ARIP4
Helicase ARIP4

1

20

Small-scale

0.501

High

587148

TMPS3
Transmembrane protease serine 3

1

3

High-throughput

0.494

High

587210

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

19

High-throughput

0.489

High

378630

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

175340

LX15B
Polyunsaturated fatty acid lipoxygenase ALOX15B

1

3

Small-scale

0.481

High

515553

SRF
Serum response factor

1

2

Small-scale

0.481

High

587123

GLPK
Glycerol kinase

1

2

High-throughput

0.481

High

587129

ACV1B
Activin receptor type-1B

1

1

High-throughput

0.481

High

587149

RAC3
Ras-related C3 botulinum toxin substrate 3

1

7

Small-scale

0.481

High

587192

NRBF2
Nuclear receptor-binding factor 2

1

1

Small-scale

0.481

High

587193

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

20

Small-scale

0.481

High

243918

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

418875

TPM3
Tropomyosin alpha-3 chain

1

11

High-throughput

0.479

High

507844

FGFR1
Fibroblast growth factor receptor 1

1

3

Small-scale

0.479

High

523513

XRCC6
X-ray repair cross-complementing protein 6

1

7

High-throughput

0.479

High

587115

LMNB1
Lamin-B1

1

18

High-throughput

0.479

High

587126

NOS2
Nitric oxide synthase, inducible

1

3

Small-scale

0.479

High

587127

MYH9
Myosin-9

1

9

High-throughput

0.479

High

587131

GRP75
Stress-70 protein, mitochondrial

1

20

Small-scale

0.479

High

587134

MATR3
Matrin-3

1

11

High-throughput

0.479

High

587140

EMD
Emerin

1

1

High-throughput

0.479

High

587141

SMCA4
Transcription activator BRG1

1

20

Small-scale

0.479

High

587142

CAZA1
F-actin-capping protein subunit alpha-1

1

2

High-throughput

0.479

High

587145

TERA
Transitional endoplasmic reticulum ATPase

1

8

Small-scale

0.479

High

587146

ANM2
Protein arginine N-methyltransferase 2

1

10

Small-scale

0.479

High

587157

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

587160

TRAF2
TNF receptor-associated factor 2

1

15

Small-scale

0.479

High

587161

TRI32
E3 ubiquitin-protein ligase TRIM32

1

14

Small-scale

0.479

High

587171

NONO
Non-POU domain-containing octamer-binding protein

1

20

High-throughput

0.479

High

587180

ZN423
Zinc finger protein 423

1

13

Small-scale

0.479

High

587181

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

20

Small-scale

0.479

High

587190

CBP
CREB-binding protein

1

20

Small-scale

0.479

High

587191

REPS1
RalBP1-associated Eps domain-containing protein 1

1

5

High-throughput

0.479

High

587197

BHE41
Class E basic helix-loop-helix protein 41

1

8

Small-scale

0.479

High

587208

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

587186

JAZF1
Juxtaposed with another zinc finger protein 1

1

0

Small-scale

0.460

High

587199

PNRC2
Proline-rich nuclear receptor coactivator 2

1

15

Small-scale

0.457

High

587158

KIF1A
Kinesin-like protein KIF1A

1

8

High-throughput

0.439

High

587124

CXCR5
C-X-C chemokine receptor type 5

1

7

Small-scale

0.437

High

587187

ZDH23
Palmitoyltransferase ZDHHC23

1

3

Small-scale

0.437

High

587201

ZDH18
Palmitoyltransferase ZDHHC18

1

1

Small-scale

0.437

High


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Last updated: 15 Jul 2024