HitPredict

Interactor 1: RU2B (P08579)
U2 small nuclear ribonucleoprotein B'' (U2 snRNP B'')
Gene: SNRPB2

Interactor 2: PPIE (Q9UNP9)
Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E)
Gene: PPIE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pro_isomerase~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck GO:0071007 - U2-type catalytic step 2 spliceosome and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 225 Hs			1 301
+	Hs
		478258 SNRPA_HUMAN (2-225): 4.07e-42: 145: 48.56		PPIE_HUMAN (1-301): 3.4e-108: 318: 100.00
+	Dm
		847883 SNRPA_DROME (1-225): 1.52e-43: 147: 64.44		PPIE_DROME (1-300): 2.07e-104: 308: 65.00
+	Hs
		1090322 ELAV2_HUMAN (128-224): 1.43e-15: 76.3: 19.61		PPIE_HUMAN (1-301): 3.4e-108: 318: 100.00
+	Hs
		250895 HNRPQ_HUMAN (4-224): 8.47e-14: 71.6: 20.00		PPIE_HUMAN (1-301): 3.4e-108: 318: 100.00
+	Hs
		344371 PTBP3_HUMAN (4-224): 2.97e-13: 70.1: 15.35		PPIE_HUMAN (1-301): 3.4e-108: 318: 100.00
+	Hs
		550522 PABP1_HUMAN (141-225): 2.64e-13: 70.1: 17.78		PPIE_HUMAN (1-301): 3.4e-108: 318: 100.00
+	Hs
		216212 PTBP3_HUMAN (4-224): 2.97e-13: 70.1: 15.35		PPIH_HUMAN (131-300): 1.25e-91: 271: 55.11
+	Hs
		986394 PABP4_HUMAN (148-225): 2e-13: 70.5: 19.28		PPIA_HUMAN (137-300): 2.23e-63: 199: 66.46
+	Hs
		986717 PABP3_HUMAN (141-225): 2.44e-12: 67.4: 17.78		PPIA_HUMAN (137-300): 2.23e-63: 199: 66.46