Protein: PPIH
Peptidyl-prolyl cis-trans isomerase H (PPIase H) (EC 5.2.1.8) (Rotamase H) (Small nuclear ribonucleoprotein particle-specific cyclophilin H) (CypH) (U-snRNP-associated cyclophilin SnuCyp-20) (USA-CYP)

Gene: PPIH
Organism: Homo sapiens
Interactions: 103
UniProt ID: O43447

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003755 - peptidyl-prolyl cis-trans isomerase activity
GO:0005654 - nucleoplasm
GO:0005681 - spliceosomal complex
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

209157

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

8

7

Small-scale

0.970

High

216253

RBM39
RNA-binding protein 39

2

7

High-throughput

0.789

High

216255

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

2

14

High-throughput

0.789

High

216262

PRP8
Pre-mRNA-processing-splicing factor 8

2

3

High-throughput

0.789

High

216282

PRP18
Pre-mRNA-splicing factor 18

2

1

High-throughput

0.783

High

216205

PPIH
Peptidyl-prolyl cis-trans isomerase H

2

9

Small-scale

0.757

High

216231

FUS
RNA-binding protein FUS

1

9

High-throughput

0.691

High

216252

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

10

High-throughput

0.691

High

216259

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

11

High-throughput

0.691

High

216284

RBM42
RNA-binding protein 42

1

4

High-throughput

0.691

High

216245

XIAP
E3 ubiquitin-protein ligase XIAP

3

2

High-throughput

0.671

High

216215

MYC
Myc proto-oncogene protein

3

7

High-throughput

0.640

High

216232

HD
Huntingtin

2

1

High-throughput

0.621

High

216216

RASN
GTPase NRas

1

6

High-throughput

0.618

High

216220

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

7

High-throughput

0.618

High

216260

LARP7
La-related protein 7

1

9

High-throughput

0.618

High

216268

THOC4
THO complex subunit 4

1

5

High-throughput

0.618

High

216279

N42L2
NEDD4-binding protein 2-like 2

3

1

High-throughput

0.616

High

216256

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

5

High-throughput

0.611

High

216299

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

6

Small-scale

0.611

High

216274

LNX1
E3 ubiquitin-protein ligase LNX

2

5

High-throughput

0.606

High

216285

NIF3L
NIF3-like protein 1

2

1

High-throughput

0.606

High

216292

UBQL2
Ubiquilin-2

2

3

High-throughput

0.606

High

214992

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

2

1

Small-scale

0.586

High

216300

LSM4
U6 snRNA-associated Sm-like protein LSm4

2

6

High-throughput

0.584

High

216266

DOK3
Docking protein 3

2

0

High-throughput

0.580

High

216229

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.549

High

216222

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

216224

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

216226

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

2

High-throughput

0.536

High

216233

KI67
Proliferation marker protein Ki-67

1

6

High-throughput

0.536

High

216235

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.536

High

216240

RUXF
Small nuclear ribonucleoprotein F

1

6

High-throughput

0.536

High

216242

SMD2
Small nuclear ribonucleoprotein Sm D2

1

2

High-throughput

0.536

High

216246

SSRP1
FACT complex subunit SSRP1

1

8

High-throughput

0.536

High

216248

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

5

High-throughput

0.536

High

216249

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

8

High-throughput

0.536

High

216250

CUL3
Cullin-3

1

5

High-throughput

0.536

High

216251

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.536

High

216257

SF3A1
Splicing factor 3A subunit 1

1

6

High-throughput

0.536

High

216271

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

2

High-throughput

0.536

High

216288

DDX21
Nucleolar RNA helicase 2

1

8

High-throughput

0.536

High

216293

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

6

High-throughput

0.536

High

216265

MEPCE
7SK snRNA methylphosphate capping enzyme

2

3

High-throughput

0.533

High

216228

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.513

High

216272

LNX2
Ligand of Numb protein X 2

1

5

High-throughput

0.512

High

216214

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.508

High

216239

NH2L1
NHP2-like protein 1

1

3

Small-scale

0.481

High

216276

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

2

Small-scale

0.481

High

142731

NFIB
Nuclear factor 1 B-type

1

4

High-throughput

0.479

High

156723

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

180626

TIF1A
Transcription intermediary factor 1-alpha

1

12

High-throughput

0.479

High

216206

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

216207

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

216209

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

216210

RECQ4
ATP-dependent DNA helicase Q4

1

11

High-throughput

0.479

High

216213

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

6

High-throughput

0.479

High

216218

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

216219

MYCN
N-myc proto-oncogene protein

1

7

High-throughput

0.479

High

216221

NFIC
Nuclear factor 1 C-type

1

5

High-throughput

0.479

High

216223

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.479

High

216227

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

216230

BRD2
Bromodomain-containing protein 2

1

4

High-throughput

0.479

High

216234

RECQ1
ATP-dependent DNA helicase Q1

1

9

High-throughput

0.479

High

216237

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.479

High

216238

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.479

High

216241

LSM6
U6 snRNA-associated Sm-like protein LSm6

1

6

High-throughput

0.479

High

216243

H4
Histone H4

1

1

High-throughput

0.479

High

216244

RL32
Large ribosomal subunit protein eL32

1

1

High-throughput

0.479

High

216247

NFIA
Nuclear factor 1 A-type

1

6

High-throughput

0.479

High

216263

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

216264

PAXI1
PAX-interacting protein 1

1

4

High-throughput

0.479

High

216267

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

High-throughput

0.479

High

216269

ZCH18
Zinc finger CCCH domain-containing protein 18

1

10

High-throughput

0.479

High

216273

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

2

Small-scale

0.479

High

216277

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

216278

ESR2
Estrogen receptor beta

1

9

High-throughput

0.479

High

216280

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

216281

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

216290

OLA1
Obg-like ATPase 1

1

3

High-throughput

0.479

High

216291

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

216294

TNIK
TRAF2 and NCK-interacting protein kinase

1

1

High-throughput

0.479

High

216295

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

216297

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

6

High-throughput

0.479

High

216298

TRRAP
Transformation/transcription domain-associated protein

1

3

High-throughput

0.479

High

128640

MEN1
Menin

1

0

High-throughput

0.458

High

216211

MET18
Histidine protein methyltransferase 1 homolog

1

0

High-throughput

0.458

High

216270

SKA3
Spindle and kinetochore-associated protein 3

1

0

Small-scale

0.458

High

216275

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

216283

B9D2
B9 domain-containing protein 2

1

0

High-throughput

0.458

High

216289

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

216208

WBP4
WW domain-binding protein 4

1

4

Small-scale

0.457

High

216258

SF01
Splicing factor 1

1

1

High-throughput

0.445

High

216261

LITD1
LINE-1 type transposase domain-containing protein 1

1

2

High-throughput

0.445

High

216217

FINC
Fibronectin

1

3

High-throughput

0.437

High

216225

ITA4
Integrin alpha-4

1

1

High-throughput

0.437

High

216254

NFIX
Nuclear factor 1 X-type

1

6

High-throughput

0.437

High

216236

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.408

High

216212

PTBP3
Polypyrimidine tract-binding protein 3

1

4

High-throughput

0.407

High

216287

BPIA1
BPI fold-containing family A member 1

2

0

High-throughput

0.316

High

216286

RESF1
Retroelement silencing factor 1

1

0

High-throughput

0.249

Low

216296

RL26L
Ribosomal protein uL24-like

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025