Interactor 1: R1AB (P0C6X7)
Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor nsp1 (Leader protein) (Non-structural protein 1) (nsp1); Non-structural protein 2 (nsp2) (p65 homolog); Papain-like protease nsp3 (PL-PRO) (EC 3.4.19.12) (EC 3.4.22.-) (Non-structural protein 3) (nsp3) (PL2-PRO); Non-structural protein 4 (nsp4); 3C-like proteinase nsp5 (3CL-PRO) (3CLp) (EC 3.4.22.69) (Main protease) (Mpro) (Non-structural protein 5) (nsp5) (SARS coronavirus main proteinase); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Viral protein genome-linked nsp9 (Non-structural protein 9) (nsp9) (RNA-capping enzyme subunit nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); RNA-directed RNA polymerase nsp12 (Pol) (RdRp) (EC 2.7.7.48) (EC 2.7.7.50) (Non-structural protein 12) (nsp12); Helicase nsp13 (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (Non-structural protein 13) (nsp13); Guanine-N7 methyltransferase nsp14 (EC 2.1.1.-) (EC 2.1.1.56) (EC 3.1.13.-) (Non-structural protein 14) (nsp14) (Proofreading exoribonuclease nsp14) (ExoN); Uridylate-specific endoribonuclease nsp15 (EC 4.6.1.-) (NendoU) (Non-structural protein 15) (nsp15); 2'-O-methyltransferase nsp16 (EC 2.1.1.57) (Non-structural protein 16) (nsp16)]
Gene: rep
Interactor 2: R1AB (P0C6X7)
Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor nsp1 (Leader protein) (Non-structural protein 1) (nsp1); Non-structural protein 2 (nsp2) (p65 homolog); Papain-like protease nsp3 (PL-PRO) (EC 3.4.19.12) (EC 3.4.22.-) (Non-structural protein 3) (nsp3) (PL2-PRO); Non-structural protein 4 (nsp4); 3C-like proteinase nsp5 (3CL-PRO) (3CLp) (EC 3.4.22.69) (Main protease) (Mpro) (Non-structural protein 5) (nsp5) (SARS coronavirus main proteinase); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Viral protein genome-linked nsp9 (Non-structural protein 9) (nsp9) (RNA-capping enzyme subunit nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); RNA-directed RNA polymerase nsp12 (Pol) (RdRp) (EC 2.7.7.48) (EC 2.7.7.50) (Non-structural protein 12) (nsp12); Helicase nsp13 (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (Non-structural protein 13) (nsp13); Guanine-N7 methyltransferase nsp14 (EC 2.1.1.-) (EC 2.1.1.56) (EC 3.1.13.-) (Non-structural protein 14) (nsp14) (Proofreading exoribonuclease nsp14) (ExoN); Uridylate-specific endoribonuclease nsp15 (EC 4.6.1.-) (NendoU) (Non-structural protein 15) (nsp15); 2'-O-methyltransferase nsp16 (EC 2.1.1.57) (Non-structural protein 16) (nsp16)]
Gene: rep
Species: Severe acute respiratory syndrome-related coronavirus
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.99 | 1.00 | 0.998 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 20420403, 25074927, 17520018, 19153232, 19436709, 32198291, 18827877, 17409150, 22659295, 16271890, 21637813, 18255185, 16242152, 15564471, 16329994, 16873247, 31138817, 29279395, 33845483, 888800000143 and 66 others
more... |
| Identification Methods | x-ray crystallography, fluorescent resonance energy transfer, pull down, two hybrid, affinity chromatography technology, enzymatic study, biochemical, molecular sieving, anti tag coimmunoprecipitation, 3D electron microscopy and 8 others
more... |
| Interaction Type | association, direct interaction, physical association, protein cleavage |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | AAA_12~AAA_12, bCoV_NAB~bCoV_NAB, Macro~bCoV_NSP3_N, CoV_ExoN~CoV_ExoN, CoV_ExoN~CoV_NSP10, CoV_ExoN~CoV_NSP9, CoV_ExoN~CoV_RPol_N, CoV_Methyltr_2~CoV_Methyltr_2, CoV_Methyltr_2~CoV_NSP10, CoV_NSP10~CoV_NSP10, CoV_NSP15_C~CoV_NSP15_C, CoV_NSP15_C~CoV_NSP15_M, CoV_NSP15_C~CoV_NSP15_N, CoV_NSP15_M~CoV_NSP15_M, CoV_NSP15_M~CoV_NSP15_N, CoV_NSP15_N~CoV_NSP15_N, CoV_NSP2_N~CoV_NSP2_N, CoV_NSP3_C~CoV_NSP3_C, CoV_NSP4_C~CoV_NSP4_C, CoV_NSP7~CoV_NSP7 and 14 others
more... |
| Common GO terms | GO:0000175 - 3'-5'-RNA exonuclease activity GO:0002151 - G-quadruplex RNA binding GO:0003727 - single-stranded RNA binding GO:0003968 - RNA-dependent RNA polymerase activity GO:0004197 - cysteine-type endopeptidase activity and 31 others more... |
| Homologous interactions | 5 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
