HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	24981860, 17719543
Identification Methods	affinity chromatography technology, enzymatic study, tandem affinity purification
Interaction Type	physical association, enzymatic reaction, association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016567 - protein ubiquitination GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 229 Hs			1 1319
+	Hs
		475470 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		476229 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		475963 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		HECW1_HUMAN (475-1317): 0: 726: 31.48
+	Hs
		475080 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Dm
		1376481 Q9W418_DROME (1-228): 2.1e-92: 282: 100.00		Q9W325_DROME (899-1316): 2.66e-179: 538: 46.10
+	Sp
		143368 UBI4P_SCHPO (1-228): 2.98e-90: 272: 96.05		PTR1_SCHPO (820-1316): 7.49e-161: 538: 33.07
+	Ce
		477557 UBIQ1_CAEEL (1-228): 9.95e-87: 275: 98.25		Q9GUP2_CAEEL (800-1316): 5.41e-158: 529: 33.96
+	Sc
		477424 UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05		TOM1_YEAST (899-1317): 8.1e-155: 520: 40.42
+	Mm
		476858 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		HUWE1_MOUSE (799-1317): 8.82e-169: 561: 35.25
+	Hs
		475984 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Hs
		125112 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91
+	Hs
		475140 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42
+	Rn
		1140970 UBC_RAT (1-181): 2.6e-61: 206: 96.13		Q5YB86_RAT (433-653): 3.99e-52: 200: 17.14
+	Hs
		475196 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86
+	Sc
		477293 UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05		RSP5_YEAST (388-669): 1.92e-30: 132: 14.41
+	Hs
		476350 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86
+	Hs
		125113 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91
+	Hs
		476205 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42
+	Hs
		476403 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86
+	Hs
		476414 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82