HitPredict

Interactor 1: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Interactor 2: UBQL2 (Q9UHD9)
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
Gene: UBQLN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	30442662, 32296183, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	UBA~ubiquitin, ubiquitin~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 229 Hs			1 624
+	Hs
		1137416 Q5U5U6_HUMAN (1-229): 4.07e-98: 286: 100.00		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		475241 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Rn
		88976 UBC_RAT (1-181): 2.6e-61: 206: 96.13		D4AA63_RAT (1-624): 5.42e-154: 459: 84.01
+	Mm
		477045 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		UBQL2_MOUSE (1-624): 1.66e-145: 437: 84.01
+	Rn
		1144285 UBC_RAT (1-181): 2.6e-61: 206: 96.13		UBQL1_RAT (1-624): 1.9e-139: 420: 69.89
+	Hs
		476438 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		UBQL4_HUMAN (22-624): 2.17e-124: 382: 54.55
+	Dm
		1375397 Q9W418_DROME (1-228): 2.1e-92: 282: 100.00		Q9VXF9_DROME (33-313): 1.35e-51: 186: 15.86
+	Hs
		474985 UBB_HUMAN (1-229): 4.07e-98: 286: 100.00		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Dm
		1362837 Q9W418_DROME (1-228): 2.1e-92: 282: 100.00		Q9VCD5_DROME (33-258): 3.37e-32: 127: 15.58
+	Dm
		574862 Q9W418_DROME (1-228): 2.1e-92: 282: 100.00		RL40_DROME (33-112): 3.08e-31: 120: 30.86
+	Sc
		477360 UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05		DSK2_YEAST (32-239): 1.13e-31: 128: 31.19
+	Mm
		57049 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		DDI2_MOUSE (43-314): 2.65e-52: 186: 15.11
+	Rn
		48892 UBC_RAT (1-181): 2.6e-61: 206: 96.13		DDI1_RAT (33-314): 1.62e-51: 184: 13.67
+	Rn
		1144200 UBC_RAT (1-181): 2.6e-61: 206: 96.13		BAG6_RAT (20-591): 8.71e-47: 179: 15.41
+	Mm
		477067 UBC_MOUSE (1-181): 6.49e-62: 207: 96.13		BAG6_MOUSE (20-591): 2.64e-44: 172: 15.09
+	Hs
		476101 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		DDI1_HUMAN (43-314): 2.92e-54: 191: 15.60
+	Hs
		475888 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	Hs
		475591 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Hs
		475590 UBC_HUMAN (1-153): 4.05e-53: 183: 99.35		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27
+	Rn
		924232 UBC_RAT (1-181): 2.6e-61: 206: 96.13		RS27A_RAT (33-119): 5.82e-13: 68.8: 27.27