Protein: IPSP
Plasma serine protease inhibitor (Acrosomal serine protease inhibitor) (Plasminogen activator inhibitor 3) (PAI-3) (PAI3) (Protein C inhibitor) (PCI) (Serpin A5)

Gene: IPSP, SERPINA5
Organism: Homo sapiens
Interactions: 64
UniProt ID: P05154

Gene Ontology (top 5):
GO:0001972 - retinoic acid binding
GO:0002020 - protease binding
GO:0002080 - acrosomal membrane
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005539 - glycosaminoglycan binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

425160

KLK3
Prostate-specific antigen

2

18

Small-scale

0.811

High

425186

HGFA
Hepatocyte growth factor activator serine protease

2

20

High-throughput

0.811

High

366459

UROK
Urokinase-type plasminogen activator

2

20

Small-scale

0.778

High

402466

PROC
Vitamin K-dependent protein C

2

20

Small-scale

0.755

High

388885

FINC
Fibronectin

1

5

Small-scale

0.734

High

366084

THRB
Prothrombin

1

20

Small-scale

0.647

High

366516

TPA
Tissue-type plasminogen activator

1

20

Small-scale

0.647

High

397992

FA11
Coagulation factor XI

1

20

Small-scale

0.647

High

398000

KLKB1
Plasma kallikrein

1

11

Small-scale

0.647

High

425163

ACRO
Acrosin

1

10

Small-scale

0.647

High

425162

FURIN
Furin

2

3

High-throughput

0.628

High

425192

TGO1
Transport and Golgi organization protein 1 homolog

2

9

High-throughput

0.628

High

425167

KLK2
Kallikrein-2

1

20

Small-scale

0.618

High

425188

EPS8
Epidermal growth factor receptor kinase substrate 8

2

3

High-throughput

0.576

High

76402

B4DTH2
Fibronectin

1

5

Small-scale

0.575

High

207785

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

2

2

High-throughput

0.574

High

425193

HECD3
E3 ubiquitin-protein ligase HECTD3

2

2

High-throughput

0.574

High

425203

WWOX
WW domain-containing oxidoreductase

2

1

High-throughput

0.574

High

425206

FBX2
F-box only protein 2

2

6

High-throughput

0.574

High

425173

CALX
Calnexin

1

4

High-throughput

0.536

High

425169

CBL
E3 ubiquitin-protein ligase CBL

2

1

High-throughput

0.526

High

425177

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.515

High

425205

BAP29
B-cell receptor-associated protein 29

1

1

High-throughput

0.515

High

214111

DHH
Desert hedgehog protein

1

0

High-throughput

0.513

High

425194

CSN6
COP9 signalosome complex subunit 6

1

1

High-throughput

0.494

High

425196

PIAS4
E3 SUMO-protein ligase PIAS4

1

1

High-throughput

0.494

High

425201

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

1

High-throughput

0.494

High

181232

PGRC2
Membrane-associated progesterone receptor component 2

1

0

High-throughput

0.493

High

425191

MSMO1
Methylsterol monooxygenase 1

1

0

High-throughput

0.493

High

280094

SC22B
Vesicle-trafficking protein SEC22b

1

1

High-throughput

0.470

High

425178

RIDA
2-iminobutanoate/2-iminopropanoate deaminase

1

0

High-throughput

0.460

High

425161

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.445

High

425168

FLNA
Filamin-A

1

1

Small-scale

0.445

High

425189

PLEC
Plectin

1

1

Small-scale

0.445

High

425197

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

2

Small-scale

0.445

High

425200

MIA2
Melanoma inhibitory activity protein 2

1

10

High-throughput

0.445

High

400107

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.437

High

131107

CLIC1
Chloride intracellular channel protein 1

1

0

Small-scale

0.426

High

403109

APOB
Apolipoprotein B-100

1

0

Small-scale

0.426

High

415268

HSPB1
Heat shock protein beta-1

1

0

Small-scale

0.426

High

425164

RS2
Small ribosomal subunit protein uS5

1

0

Small-scale

0.426

High

425166

RL7
Large ribosomal subunit protein uL30

1

0

Small-scale

0.426

High

425171

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.426

High

425172

RL13
Large ribosomal subunit protein eL13

1

0

Small-scale

0.426

High

425174

PRDX6
Peroxiredoxin-6

1

0

Small-scale

0.426

High

425175

CAPZB
F-actin-capping protein subunit beta

1

0

Small-scale

0.426

High

425179

IF6
Eukaryotic translation initiation factor 6

1

0

Small-scale

0.426

High

425180

RS8
Small ribosomal subunit protein eS8

1

0

Small-scale

0.426

High

425181

RS6
Small ribosomal subunit protein eS6

1

0

Small-scale

0.426

High

425182

RL10A
Large ribosomal subunit protein uL1

1

0

Small-scale

0.426

High

425183

RL8
Large ribosomal subunit protein uL2

1

0

Small-scale

0.426

High

425185

CLH1
Clathrin heavy chain 1

1

0

Small-scale

0.426

High

425187

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.417

High

258046

IF2P
Eukaryotic translation initiation factor 5B

1

1

Small-scale

0.407

High

425176

MCM2
DNA replication licensing factor MCM2

1

5

Small-scale

0.407

High

425202

XPO5
Exportin-5

1

1

Small-scale

0.407

High

425199

ESIP1
Epithelial-stromal interaction protein 1

2

0

High-throughput

0.328

High

425165

H15
Histone H1.5

1

0

High-throughput

0.269

Low

425170

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

425184

SERB
Phosphoserine phosphatase

1

0

Small-scale

0.232

Low

425190

SF3B3
Splicing factor 3B subunit 3

1

0

Small-scale

0.232

Low

425195

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

Small-scale

0.232

Low

425198

RENT1
Regulator of nonsense transcripts 1

1

0

Small-scale

0.232

Low

425204

SYLC
Leucine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025