HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBP14 (P54578)
Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14)
Gene: USP14

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.962

Property	Details
Experiments	27066941, 23287719, 28190767, 29576527, 33141564, 34642328, 36114200, 23801757
Identification Methods	enzymatic study, unspecified method, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UCH~ubiquitin
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 494
+	Hs
		476400 UBC_HUMAN (1-685): 0: 846: 100.00		UBP42_HUMAN (59-482): 3.47e-89: 299: 17.37
+	Hs
		476493 UBC_HUMAN (1-685): 0: 846: 100.00		UBP36_HUMAN (65-482): 3.73e-90: 299: 17.54
+	Hs
		259261 UBC_HUMAN (1-685): 0: 846: 100.00		UBP12_HUMAN (61-484): 1.14e-95: 295: 18.49
+	Hs
		475440 UBC_HUMAN (1-685): 0: 846: 100.00		UBP8_HUMAN (42-489): 9.27e-89: 295: 18.07
+	Hs
		475566 UBC_HUMAN (1-685): 0: 846: 100.00		UBP46_HUMAN (61-483): 1.58e-95: 295: 18.76
+	Hs
		64200 UBC_HUMAN (1-685): 0: 846: 100.00		UBP27_HUMAN (35-494): 3.18e-94: 294: 18.41
+	Hs
		476579 UBC_HUMAN (1-685): 0: 846: 100.00		UBP22_HUMAN (66-487): 1.12e-91: 290: 19.03
+	Hs
		271022 UBC_HUMAN (1-685): 0: 846: 100.00		UBP2_HUMAN (56-487): 5.71e-90: 288: 16.30
+	Hs
		475932 UBC_HUMAN (1-685): 0: 846: 100.00		U17L2_HUMAN (82-492): 7.98e-90: 285: 19.37
+	Hs
		476545 UBC_HUMAN (1-685): 0: 846: 100.00		UBP21_HUMAN (29-486): 4.53e-88: 282: 16.80
+	Hs
		476658 UBC_HUMAN (1-685): 0: 846: 100.00		UBP3_HUMAN (47-491): 2.12e-88: 282: 16.02
+	At
		1210479 UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80		UBP15_ARATH (57-483): 5.45e-84: 280: 19.55
+	Sc
		477337 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP6_YEAST (4-481): 1.15e-88: 282: 30.10
+	At
		1091915 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBP6_ARATH (1-483): 1.59e-115: 350: 41.28
+	Hs
		870741 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		UBP14_HUMAN (1-494): 7.04e-147: 431: 100.00
+	At
		1092065 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBP15_ARATH (57-483): 5.45e-84: 280: 19.55
+	Dm
		1099208 R9PY16_DROME (457-685): 5.07e-80: 258: 90.39		UBPE_DROME (66-489): 3.68e-87: 294: 17.53
+	Sc
		477366 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP8_YEAST (105-485): 5.83e-38: 146: 20.51
+	Hs
		924201 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		UBP36_HUMAN (65-482): 3.73e-90: 299: 17.54
+	Mm
		476741 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP46_MOUSE (61-483): 1.58e-95: 295: 18.76