HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.928

Property	Details
Experiments	38803224, 18931663, 22194841, 23259674, 17318174
Identification Methods	pull down, x-ray crystallography, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4_3
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 497
+	Hs
		475719 UBC_HUMAN (1-685): 0: 846: 100.00		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Hs
		475718 UBC_HUMAN (1-685): 0: 846: 100.00		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Hs
		476171 UBC_HUMAN (1-685): 0: 846: 100.00		BIRC7_HUMAN (14-155): 1.47e-36: 138: 21.83
+	Hs
		476431 UBC_HUMAN (1-685): 0: 846: 100.00		BIRC6_HUMAN (258-442): 3.1e-26: 115: 18.78
+	Hs
		475933 UBC_HUMAN (1-685): 0: 846: 100.00		LRSM1_HUMAN (330-497): 2.09e-24: 108: 18.45
+	Hs
		476011 UBC_HUMAN (1-685): 0: 846: 100.00		MIB1_HUMAN (311-492): 5.04e-16: 83.1: 13.68
+	Hs
		476162 UBC_HUMAN (1-685): 0: 846: 100.00		MIB2_HUMAN (437-496): 2e-10: 65.3: 35.00
+	Xl
		1151527 Q7SY79_XENLA (77-685): 0: 744: 99.84		MIB1_XENLA (311-492): 8.86e-16: 82.3: 13.15
+	Hs
		474994 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Rn
		1144301 UBC_RAT (1-108): 1.27e-29: 127: 90.74		XIAP_RAT (1-497): 0: 549: 89.14
+	Mm
		476824 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		XIAP_MOUSE (1-497): 0: 544: 88.73
+	At
		1091822 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		MIP1_ARATH (320-495): 9.98e-25: 110: 17.80
+	Mm
		140018 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		BIRC3_MOUSE (150-342): 6.21e-40: 154: 27.16
+	Hs
		475022 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Mm
		476925 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		MIB2_MOUSE (422-496): 9.81e-17: 85.3: 29.33
+	Hs
		171467 UBD_HUMAN (155-304): 5.41e-28: 112: 32.05		BIRC5_HUMAN (266-372): 1.61e-21: 92.3: 26.32