HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: BIRC3 (Q13489)
Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1)
Gene: BIRC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	25494483, 18931663, 23259674
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CARD~ubiquitin, ubiquitin~zf-C3HC4_3
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 604
+	Hs
		475719 UBC_HUMAN (1-685): 0: 846: 100.00		BIRC2_HUMAN (2-604): 0: 643: 72.31
+	Hs
		475629 UBC_HUMAN (1-685): 0: 846: 100.00		XIAP_HUMAN (168-604): 1.28e-83: 272: 24.21
+	Hs
		476431 UBC_HUMAN (1-685): 0: 846: 100.00		BIRC6_HUMAN (7-136): 3.42e-35: 144: 20.29
+	Hs
		476171 UBC_HUMAN (1-685): 0: 846: 100.00		BIRC7_HUMAN (13-165): 1.87e-34: 134: 21.80
+	Hs
		476162 UBC_HUMAN (1-685): 0: 846: 100.00		MIB2_HUMAN (544-603): 2.9e-10: 65.3: 35.00
+	Mm
		140018 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		BIRC3_MOUSE (3-604): 0: 662: 73.92
+	Hs
		475022 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		BIRC3_HUMAN (1-604): 0: 676: 100.00
+	At
		1091822 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		MIP1_ARATH (306-602): 3.29e-37: 149: 15.55
+	Rn
		1144301 UBC_RAT (1-108): 1.27e-29: 127: 90.74		XIAP_RAT (147-604): 5.81e-80: 262: 23.81
+	Mm
		476824 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		XIAP_MOUSE (147-604): 9.05e-80: 262: 24.00
+	Hs
		474994 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		XIAP_HUMAN (168-604): 1.28e-83: 272: 24.21
+	Hs
		171467 UBD_HUMAN (155-304): 5.41e-28: 112: 32.05		BIRC5_HUMAN (258-332): 1.39e-25: 104: 35.00
+	Mm
		476925 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		MIB2_MOUSE (544-603): 3.29e-10: 65.3: 35.00