HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBP33 (Q8TEY7)
Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1)
Gene: USP33

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	29576527, 24377933
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	DUSP~ubiquitin, UCH~ubiquitin, ubiquitin~zf-UBP
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 942
+	Hs
		476599 UBC_HUMAN (1-685): 0: 846: 100.00		UBP20_HUMAN (32-942): 0: 778: 58.27
+	Hs
		475502 UBC_HUMAN (1-685): 0: 846: 100.00		UBP11_HUMAN (80-716): 8.74e-126: 406: 17.53
+	Hs
		475693 UBC_HUMAN (1-685): 0: 846: 100.00		UBP4_HUMAN (111-723): 6.57e-123: 398: 17.71
+	Hs
		476644 UBC_HUMAN (1-685): 0: 846: 100.00		UBP16_HUMAN (20-714): 1.9e-120: 388: 19.08
+	Hs
		475957 UBC_HUMAN (1-685): 0: 846: 100.00		UBP45_HUMAN (12-715): 4.67e-109: 357: 17.39
+	Hs
		476624 UBC_HUMAN (1-685): 0: 846: 100.00		UBP15_HUMAN (162-719): 1.12e-104: 350: 17.06
+	Hs
		475461 UBC_HUMAN (1-685): 0: 846: 100.00		UBP5_HUMAN (12-715): 1.71e-96: 325: 13.20
+	Hs
		475954 UBC_HUMAN (1-685): 0: 846: 100.00		UBP31_HUMAN (183-851): 1.79e-93: 325: 16.56
+	Hs
		476145 UBC_HUMAN (1-685): 0: 846: 100.00		UBP13_HUMAN (6-717): 1.13e-93: 317: 12.87
+	Hs
		296262 UBC_HUMAN (1-685): 0: 846: 100.00		UBP1_HUMAN (124-679): 5.43e-70: 250: 17.29
+	Hs
		476658 UBC_HUMAN (1-685): 0: 846: 100.00		UBP3_HUMAN (39-321): 8.7e-62: 220: 26.02
+	Hs
		476579 UBC_HUMAN (1-685): 0: 846: 100.00		UBP22_HUMAN (363-720): 8.74e-59: 212: 22.13
+	Hs
		64200 UBC_HUMAN (1-685): 0: 846: 100.00		UBP27_HUMAN (111-460): 2.41e-52: 191: 16.62
+	Hs
		271022 UBC_HUMAN (1-685): 0: 846: 100.00		UBP2_HUMAN (119-466): 3.22e-49: 186: 18.07
+	Hs
		476545 UBC_HUMAN (1-685): 0: 846: 100.00		UBP21_HUMAN (146-421): 1.31e-40: 160: 18.56
+	Hs
		475440 UBC_HUMAN (1-685): 0: 846: 100.00		UBP8_HUMAN (125-330): 4.91e-39: 159: 25.94
+	Hs
		475995 UBC_HUMAN (1-685): 0: 846: 100.00		UBP48_HUMAN (110-476): 1.33e-37: 154: 14.29
+	Dm
		477538 UBIQP_DROME (1-610): 0: 752: 99.84		NOT_DROME (61-327): 9.54e-55: 200: 21.90
+	Sc
		477398 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP10_YEAST (466-714): 2.65e-21: 102: 32.35
+	Sc
		477284 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP12_YEAST (98-298): 4.05e-13: 75.9: 28.07