HitPredict

Interactor 1: RPB1 (P08775)
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)
Gene: Polr2a

Interactor 2: WWP2 (Q9DBH0)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	17526739
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006366 - transcription by RNA polymerase II
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1970 Mm			1 870
+	Hs
		131738 RPB1_HUMAN (1-1611): 0: 1902: 100.00		WWP2_HUMAN (1-870): 0: 950: 95.98
+	Hs
		667408 RPB1_HUMAN (1-1611): 0: 1902: 100.00		ITCH_HUMAN (1-870): 0: 866: 55.56
+	Hs
		667443 RPB1_HUMAN (1-1611): 0: 1902: 100.00		WWP1_HUMAN (1-870): 0: 856: 57.30
+	Hs
		667206 RPB1_HUMAN (1-1611): 0: 1902: 100.00		NEDD4_HUMAN (90-868): 0: 735: 35.88
+	Hs
		667356 RPB1_HUMAN (1-1611): 0: 1902: 100.00		HUWE1_HUMAN (94-869): 3.03e-177: 570: 26.62
+	Sc
		402014 RPB1_YEAST (11-1599): 0: 1626: 49.31		RSP5_YEAST (16-870): 0: 675: 33.45
+	Hs
		165020 RPC1_HUMAN (16-1487): 0: 1358: 33.36		NEDD4_HUMAN (90-868): 0: 735: 35.88
+	Hs
		667464 RPB1_HUMAN (1-1611): 0: 1902: 100.00		SMUF1_HUMAN (1-462): 2.16e-41: 165: 13.65
+	Dm
		1486711 Q9VUH6_DROME (1423-1873): 2.04e-11: 71.8: 13.04		SUDX_DROME (14-870): 0: 820: 51.76