HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: GGA3 (Q9NZ52)
ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3)
Gene: GGA3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.975

Property	Details
Experiments	15494413, 28190767, 28581508, 38803224, 14660606, 20484053, 16135791, 15966896, 15701688
Identification Methods	pull down, affinity chromatography technology, two hybrid, x-ray crystallography
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	GAT~ubiquitin, VHS~ubiquitin
Common GO terms	GO:0010008 - endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 723
+	Hs
		476541 UBC_HUMAN (1-685): 0: 846: 100.00		GGA1_HUMAN (2-723): 1.09e-91: 301: 39.78
+	Hs
		475949 UBC_HUMAN (1-685): 0: 846: 100.00		TM1L2_HUMAN (7-511): 5.58e-88: 287: 21.58
+	Hs
		241137 UBC_HUMAN (1-685): 0: 846: 100.00		TOM1_HUMAN (7-402): 8.19e-85: 278: 22.76
+	Hs
		276993 UBC_HUMAN (1-685): 0: 846: 100.00		STAM2_HUMAN (1-480): 4.23e-79: 264: 16.95
+	Hs
		476138 UBC_HUMAN (1-685): 0: 846: 100.00		STAM1_HUMAN (1-522): 4.18e-75: 254: 17.10
+	Hs
		272789 UBC_HUMAN (1-685): 0: 846: 100.00		TM1L1_HUMAN (6-473): 8.9e-63: 219: 16.50
+	Hs
		159860 UBC_HUMAN (1-685): 0: 846: 100.00		HGS_HUMAN (8-709): 5.07e-58: 212: 13.37
+	Bt
		477668 UBC_BOVIN (1-613): 0: 753: 99.18		Q58CQ6_BOVIN (2-452): 5.4e-89: 287: 46.93
+	Zm
		111864 Q42415_MAIZE (229-685): 0: 548: 95.84		K7VAA4_MAIZE (493-715): 9.58e-58: 212: 25.69
+	Sc
		477454 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		GGA1_YEAST (2-425): 1.01e-68: 237: 21.28
+	Sc
		477270 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		GGA2_YEAST (2-437): 2.07e-66: 231: 21.70
+	Sc
		477314 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		VPS27_YEAST (1-595): 9.4e-65: 228: 14.56
+	Zm
		111863 Q41754_MAIZE (381-685): 3.03e-124: 375: 95.74		K7VAA4_MAIZE (493-715): 9.58e-58: 212: 25.69
+	Ce
		477552 UBIQ1_CAEEL (1-229): 5.97e-87: 292: 98.25		Q17796_CAEEL (6-400): 1.98e-66: 235: 14.21
+	At
		1092009 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		TOL5_ARATH (9-350): 5.16e-63: 218: 15.61
+	Ce
		136432 UBIQ1_CAEEL (1-229): 5.97e-87: 292: 98.25		STAM1_CAEEL (4-462): 8.67e-54: 194: 15.76
+	At
		285943 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		TOL6_ARATH (14-617): 5.35e-56: 204: 14.72
+	Hs
		277047 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		STAM2_HUMAN (1-480): 4.23e-79: 264: 16.95
+	Hs
		924099 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		STAM1_HUMAN (1-522): 4.18e-75: 254: 17.10
+	Mm
		292209 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		TOM1_MOUSE (7-460): 2.12e-80: 266: 20.92