HitPredict

Interactor 1: UBI4P (P0CG63)
Polyubiquitin [Cleaved into: Ubiquitin]
Gene: UBI4

Interactor 2: UBA1 (P22515)
Ubiquitin-activating enzyme E1 1 (EC 6.2.1.45)
Gene: UBA1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.924

Property	Details
Experiments	18662542, 26142280, 37968396, 2265617, 1989885
Identification Methods	x-ray crystallography, pull down, affinity chromatography technology, enzymatic study
Interaction Type	association, direct interaction, physical association

Property	Details
Interacting Pfam domains	ThiF~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0016567 - protein ubiquitination
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 381 Sc			1 1024
+	Rn
		1137285 UBC_RAT (1-333): 8.71e-131: 395: 93.99		UBA1_RAT (2-1023): 0: 1111: 51.74
+	Mm
		476770 UBC_MOUSE (1-333): 9.24e-132: 396: 93.99		UBA1_MOUSE (2-1023): 0: 1107: 51.65
+	At
		955613 UBQ3_ARATH (77-381): 2.59e-125: 365: 97.05		UBE11_ARATH (7-1024): 0: 1018: 44.41
+	Sc
		408274 RS31_YEAST (305-380): 1.88e-41: 144: 100.00		UBA1_YEAST (1-1024): 0: 1089: 100.00
+	Hs
		48090 UBC_HUMAN (1-153): 1.84e-50: 181: 95.43		UBA6_HUMAN (2-1024): 0: 966: 40.81
+	Hs
		48082 UBD_HUMAN (231-380): 1.48e-30: 116: 30.77		UBA6_HUMAN (2-1024): 0: 966: 40.81
+	Hs
		397822 ISG15_HUMAN (3-152): 9.45e-31: 117: 32.68		UBA7_HUMAN (5-1024): 0: 909: 36.99
+	Sc
		477515 UBI4P_YEAST (1-381): 4.37e-161: 458: 100.00		UBA3_YEAST (434-619): 7.64e-23: 102: 30.46
+	Rn
		1144252 UBC_RAT (1-333): 8.71e-131: 395: 93.99		UBA3_RAT (790-994): 8.81e-41: 158: 14.55
+	Mm
		476902 UBC_MOUSE (1-333): 9.24e-132: 396: 93.99		UBA6_MOUSE (373-576): 1.55e-21: 103: 17.31
+	Hs
		476506 UBC_HUMAN (1-153): 1.84e-50: 181: 95.43		SAE2_HUMAN (24-413): 8.43e-82: 280: 15.72
+	Hs
		171508 UBD_HUMAN (231-380): 1.48e-30: 116: 30.77		SAE2_HUMAN (24-413): 8.43e-82: 280: 15.72
+	Hs
		171506 UBD_HUMAN (231-380): 1.48e-30: 116: 30.77		SAE1_HUMAN (409-706): 1.78e-61: 215: 20.46
+	Hs
		475337 UBC_HUMAN (1-153): 1.84e-50: 181: 95.43		UBA1_HUMAN (393-622): 1.44e-27: 123: 17.75
+	At
		790154 RUB1_ARATH (77-229): 4.24e-50: 167: 79.09		AXR1_ARATH (94-395): 1.57e-15: 82.9: 16.51
+	Hs
		171474 UBD_HUMAN (231-380): 1.48e-30: 116: 30.77		UBA1_HUMAN (393-622): 1.44e-27: 123: 17.75
+	Hs
		607051 RS27A_HUMAN (77-153): 8.44e-20: 87: 94.81		UBA1_HUMAN (393-622): 1.44e-27: 123: 17.75