HitPredict

Interactor 1: UBA6 (A0AVT1)
Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)
Gene: UBA6

Interactor 2: UB2L6 (O14933)
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6)
Gene: UBE2L6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	19250909, 33961781
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1052 Hs			1 153
+	Hs
		159017 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2L6_HUMAN (1-153): 2.2e-98: 281: 100.00
+	Hs
		48104 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93
+	Hs
		48107 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58
+	Hs
		48106 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2D3_HUMAN (2-149): 5.99e-74: 219: 36.24
+	Hs
		607190 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D4_HUMAN (2-149): 5.5e-76: 224: 38.93
+	Hs
		607026 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D1_HUMAN (2-149): 1.04e-75: 223: 38.93
+	Hs
		607050 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D2_HUMAN (2-149): 3.7e-75: 222: 37.58
+	Hs
		607039 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D3_HUMAN (2-149): 5.99e-74: 219: 36.24
+	Hs
		48108 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2L3_HUMAN (1-152): 6.11e-66: 199: 55.26
+	Hs
		607136 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2E2_HUMAN (3-148): 7.71e-69: 208: 32.65
+	Hs
		607129 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2E3_HUMAN (3-148): 1.55e-68: 207: 31.97
+	Hs
		607028 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2E1_HUMAN (3-148): 5.11e-67: 203: 34.01
+	Hs
		607057 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2L3_HUMAN (1-152): 6.11e-66: 199: 55.26
+	Hs
		607042 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2N_HUMAN (4-151): 4.19e-65: 197: 29.73
+	Hs
		607023 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2A_HUMAN (3-147): 7.09e-65: 196: 30.14
+	Hs
		48135 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UBE2T_HUMAN (1-144): 1.52e-20: 85.1: 33.33
+	Hs
		607169 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2T_HUMAN (1-144): 1.52e-20: 85.1: 33.33
+	Sp
		293848 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC4_SCHPO (2-148): 4.92e-74: 219: 36.49
+	Sp
		142467 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC13_SCHPO (1-149): 4.35e-22: 87.8: 34.90
+	Sp
		293851 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC14_SCHPO (7-148): 1.89e-21: 86.3: 36.36