HitPredict

Interactor 1: UBA6 (A0AVT1)
Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)
Gene: UBA6

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.899

Property	Details
Experiments	27182664, 22427669, 23003343, 17550899
Identification Methods	enzymatic study, pull down, unspecified method, proximity labelling technology, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	ThiF~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1052 Hs			1 685
+	Hs
		475337 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBC_HUMAN (1-685): 0: 846: 100.00
+	Sc
		477133 UBA1_YEAST (24-1046): 0: 979: 40.52		UBI4P_YEAST (381-685): 5e-122: 370: 95.74
+	At
		955613 UBE11_ARATH (32-1047): 0: 1025: 37.44		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Hs
		607051 UBA1_HUMAN (1-1045): 0: 1139: 40.92		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Hs
		48082 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UBD_HUMAN (155-304): 5.41e-28: 112: 32.05
+	Mm
		476902 UBA6_MOUSE (1-1052): 0: 1136: 89.07		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Rn
		1137285 UBA1_RAT (1-1045): 0: 1128: 41.20		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Mm
		476770 UBA1_MOUSE (1-1045): 0: 1126: 40.83		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		171474 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBD_HUMAN (155-304): 5.41e-28: 112: 32.05
+	Hs
		476506 SAE2_HUMAN (49-418): 1.82e-78: 272: 13.64		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		397822 UBA7_HUMAN (34-1045): 0: 905: 36.34		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69
+	Sc
		477515 UBA3_YEAST (463-640): 6.31e-23: 102: 32.80		UBI4P_YEAST (381-685): 5e-122: 370: 95.74
+	Hs
		171508 SAE2_HUMAN (49-418): 1.82e-78: 272: 13.64		UBD_HUMAN (155-304): 5.41e-28: 112: 32.05
+	Hs
		171506 SAE1_HUMAN (427-692): 3.45e-58: 206: 15.36		UBD_HUMAN (155-304): 5.41e-28: 112: 32.05
+	Rn
		1144252 UBA3_RAT (852-1017): 5.69e-40: 156: 19.19		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	At
		790154 AXR1_ARATH (162-427): 8.46e-17: 87.2: 17.52		RUB1_ARATH (457-609): 8.21e-49: 169: 78.43