HitPredict

Interactor 1: UBA6 (A0AVT1)
Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)
Gene: UBA6

Interactor 2: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	17597759
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1052 Hs			1 147
+	Hs
		48107 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12
+	Hs
		48106 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44
+	Hs
		607190 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84
+	Hs
		607026 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00
+	Hs
		607050 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12
+	Hs
		607039 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44
+	Hs
		607136 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2E2_HUMAN (4-146): 3.11e-74: 221: 62.94
+	Hs
		607129 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2E3_HUMAN (4-146): 1.2e-73: 220: 62.94
+	Hs
		607028 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2E1_HUMAN (4-146): 3.94e-72: 216: 62.94
+	Hs
		607023 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2A_HUMAN (2-144): 2.83e-70: 209: 40.56
+	Hs
		607054 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2B_HUMAN (2-144): 1.35e-69: 208: 39.16
+	Hs
		607042 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83
+	Sp
		293848 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC4_SCHPO (1-147): 6.75e-80: 234: 79.59
+	Sc
		549788 UBA1_YEAST (24-1046): 0: 979: 40.52		UBC4_YEAST (3-147): 3.9e-79: 232: 79.31
+	Dm
		715098 Q8T0L3_DROME (21-1045): 0: 990: 40.89		UBE2N_DROME (4-147): 1.38e-72: 215: 47.92
+	Sp
		251976 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC1_SCHPO (4-146): 6.62e-45: 147: 46.53
+	Sp
		142467 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC13_SCHPO (1-147): 9.06e-45: 145: 50.68
+	Sp
		293851 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC14_SCHPO (6-146): 3.45e-42: 139: 46.48
+	Sc
		600919 UBA1_YEAST (24-1046): 0: 979: 40.52		UBC1_YEAST (4-146): 2.12e-43: 144: 46.21
+	Hs
		782203 UBA7_HUMAN (34-1045): 0: 905: 36.34		UB2E1_HUMAN (4-146): 3.94e-72: 216: 62.94