Protein: AGO3
Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)

Gene: AGO3
Organism: Homo sapiens
Interactions: 153
UniProt ID: Q9H9G7

Gene Ontology (top 5):
GO:0000794 - condensed nuclear chromosome
GO:0000932 - P-body
GO:0003723 - RNA binding
GO:0003725 - double-stranded RNA binding
GO:0003727 - single-stranded RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1437076

AGO2
Protein argonaute-2

5

12

High-throughput

0.919

High

1437064

AGO4
Protein argonaute-4

3

12

High-throughput

0.861

High

1437081

DICER
Endoribonuclease Dicer

3

20

Small-scale

0.847

High

1437078

AGO1
Protein argonaute-1

3

12

High-throughput

0.839

High

1336845

TNR6A
Trinucleotide repeat-containing gene 6A protein

8

17

Small-scale

0.750

High

1437080

TNR6B
Trinucleotide repeat-containing gene 6B protein

7

17

Small-scale

0.748

High

1437063

TNR6C
Trinucleotide repeat-containing gene 6C protein

4

20

Small-scale

0.696

High

1106077

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

4

15

High-throughput

0.694

High

461944

HS90A
Heat shock protein HSP 90-alpha

4

20

High-throughput

0.691

High

126188

AP3B1
AP-3 complex subunit beta-1

3

2

High-throughput

0.667

High

158887

AP3D1
AP-3 complex subunit delta-1

3

3

High-throughput

0.667

High

1193281

LONF3
LON peptidase N-terminal domain and RING finger protein 3

3

20

High-throughput

0.667

High

346352

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

16

High-throughput

0.618

High

1150698

TRBP2
RISC-loading complex subunit TARBP2

1

15

High-throughput

0.618

High

1032415

OTUD4
OTU domain-containing protein 4

2

1

High-throughput

0.611

High

1308404

ANKY2
Ankyrin repeat and MYND domain-containing protein 2

3

6

High-throughput

0.609

High

1364936

AP3S1
AP-3 complex subunit sigma-1

3

2

High-throughput

0.609

High

189281

IPO8
Importin-8

1

5

High-throughput

0.586

High

1437065

MOG1
Ran guanine nucleotide release factor

2

0

High-throughput

0.585

High

916706

PPP5
Serine/threonine-protein phosphatase 5

1

5

High-throughput

0.554

High

1202009

H90B4
Putative heat shock protein HSP 90-beta 4

2

20

High-throughput

0.552

High

1202075

HS905
Putative heat shock protein HSP 90-alpha A5

2

20

High-throughput

0.552

High

564384

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

162699

ANM5
Protein arginine N-methyltransferase 5

1

3

High-throughput

0.536

High

408169

TBB4A
Tubulin beta-4A chain

1

7

High-throughput

0.536

High

457708

TBB5
Tubulin beta chain

1

7

High-throughput

0.536

High

468817

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.536

High

539419

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

4

High-throughput

0.536

High

623546

RO52
E3 ubiquitin-protein ligase TRIM21

1

3

High-throughput

0.536

High

637740

FLNA
Filamin-A

1

2

High-throughput

0.536

High

660730

IF4B
Eukaryotic translation initiation factor 4B

1

13

High-throughput

0.536

High

727971

DNJA1
DnaJ homolog subfamily A member 1

1

8

High-throughput

0.536

High

773028

MYH9
Myosin-9

1

4

High-throughput

0.536

High

773643

COPB2
Coatomer subunit beta'

1

4

High-throughput

0.536

High

801533

HSPA9
Stress-70 protein, mitochondrial

1

9

High-throughput

0.536

High

813221

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

2

High-throughput

0.536

High

882167

TCPG
T-complex protein 1 subunit gamma

1

4

High-throughput

0.536

High

926226

ICLN
Methylosome subunit pICln

1

1

High-throughput

0.536

High

996341

EF1A1
Elongation factor 1-alpha 1

1

3

High-throughput

0.536

High

997517

TBB4B
Tubulin beta-4B chain

1

7

High-throughput

0.536

High

1028878

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

2

High-throughput

0.536

High

1114328

CUL3
Cullin-3

1

6

High-throughput

0.536

High

1117487

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

3

High-throughput

0.536

High

1118601

TBB2A
Tubulin beta-2A chain

1

7

High-throughput

0.536

High

1144167

TEBP
Prostaglandin E synthase 3

1

10

High-throughput

0.536

High

1153119

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

1

High-throughput

0.536

High

1259509

TBA1A
Tubulin alpha-1A chain

1

6

High-throughput

0.536

High

1291220

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

5

High-throughput

0.536

High

1359923

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

2

High-throughput

0.536

High

1360484

PSPC1
Paraspeckle component 1

1

13

High-throughput

0.536

High

1371869

CUL5
Cullin-5

1

6

High-throughput

0.536

High

1382385

SPSB4
SPRY domain-containing SOCS box protein 4

1

7

High-throughput

0.536

High

1406044

PHB2
Prohibitin-2

1

4

High-throughput

0.536

High

1410374

MEP50
Methylosome protein WDR77

1

7

High-throughput

0.536

High

1437069

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

1

High-throughput

0.536

High

1437082

RUVB2
RuvB-like 2

1

3

High-throughput

0.536

High

1437087

SF3B6
Splicing factor 3B subunit 6

1

9

High-throughput

0.536

High

183969

S22A2
Solute carrier family 22 member 2

1

0

High-throughput

0.518

High

660301

BDNF
Neurotrophic factor BDNF precursor form

1

0

High-throughput

0.518

High

1331448

VA0D2
V-type proton ATPase subunit d 2

1

0

High-throughput

0.518

High

158325

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

1144313

STK38
Serine/threonine-protein kinase 38

1

0

High-throughput

0.513

High

1293535

CIR1
Corepressor interacting with RBPJ 1

1

0

High-throughput

0.513

High

1437073

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.513

High

1437077

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.513

High

1437083

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.513

High

1437088

FBX7
F-box only protein 7

1

0

High-throughput

0.513

High

1437090

SPIN1
Spindlin-1

1

0

High-throughput

0.513

High

1214797

ATD3B
ATPase family AAA domain-containing protein 3B

1

3

High-throughput

0.489

High

66052

WTIP
Wilms tumor protein 1-interacting protein

1

7

Small-scale

0.479

High

173382

XPO1
Exportin-1

1

3

High-throughput

0.479

High

176550

GRRE1
Granule associated Rac and RHOG effector protein 1

1

2

High-throughput

0.479

High

180928

TIF1A
Transcription intermediary factor 1-alpha

1

13

Small-scale

0.479

High

194353

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

213491

CTIF
CBP80/20-dependent translation initiation factor

1

4

High-throughput

0.479

High

274239

ANR17
Ankyrin repeat domain-containing protein 17

1

3

High-throughput

0.479

High

331333

KI20A
Kinesin-like protein KIF20A

1

9

High-throughput

0.479

High

373175

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.479

High

401502

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

406657

MYCN
N-myc proto-oncogene protein

1

5

High-throughput

0.479

High

409087

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

5

High-throughput

0.479

High

508650

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

High-throughput

0.479

High

531151

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

1

High-throughput

0.479

High

550470

PABP1
Polyadenylate-binding protein 1

1

10

High-throughput

0.479

High

657686

GCSP
Glycine dehydrogenase

1

2

High-throughput

0.479

High

684395

DDX6
Probable ATP-dependent RNA helicase DDX6

1

20

High-throughput

0.479

High

688316

TTP
mRNA decay activator protein ZFP36

1

5

High-throughput

0.479

High

692137

MARK3
MAP/microtubule affinity-regulating kinase 3

1

11

High-throughput

0.479

High

696540

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

713854

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

18

High-throughput

0.479

High

769208

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

799481

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.479

High

875786

PRC2A
Protein PRRC2A

1

5

High-throughput

0.479

High

900517

FXR2
RNA-binding protein FXR2

1

16

High-throughput

0.479

High

1027765

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

5

High-throughput

0.479

High

1035924

KIF23
Kinesin-like protein KIF23

1

5

High-throughput

0.479

High

1101033

G3BP1
Ras GTPase-activating protein-binding protein 1

1

6

High-throughput

0.479

High

1120343

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

15

Small-scale

0.479

High

1122167

UBP2L
Ubiquitin-associated protein 2-like

1

2

High-throughput

0.479

High

1129508

PUM1
Pumilio homolog 1

1

4

High-throughput

0.479

High

1135111

CUL7
Cullin-7

1

3

High-throughput

0.479

High

1140881

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.479

High

1165507

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

17

High-throughput

0.479

High

1215837

RC3H1
Roquin-1

1

4

High-throughput

0.479

High

1241500

EDC4
Enhancer of mRNA-decapping protein 4

1

2

Small-scale

0.479

High

1241589

CEP85
Centrosomal protein of 85 kDa

1

7

High-throughput

0.479

High

1252389

MEX3B
RNA-binding protein MEX3B

1

6

High-throughput

0.479

High

1255585

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1270527

MARK2
Serine/threonine-protein kinase MARK2

1

11

High-throughput

0.479

High

1275682

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

4

High-throughput

0.479

High

1280743

YTHD3
YTH domain-containing family protein 3

1

9

High-throughput

0.479

High

1287129

PATL1
Protein PAT1 homolog 1

1

7

High-throughput

0.479

High

1310652

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

14

High-throughput

0.479

High

1336300

LS14A
Protein LSM14 homolog A

1

5

High-throughput

0.479

High

1359704

PHIP
PH-interacting protein

1

1

High-throughput

0.479

High

1365361

CNOT9
CCR4-NOT transcription complex subunit 9

1

2

High-throughput

0.479

High

1369579

ATOH1
Transcription factor ATOH1

1

2

Small-scale

0.479

High

1369845

CELF1
CUGBP Elav-like family member 1

1

13

High-throughput

0.479

High

1370244

DAZL
Deleted in azoospermia-like

1

17

High-throughput

0.479

High

1391178

BICD1
Protein bicaudal D homolog 1

1

7

High-throughput

0.479

High

1393956

FUBP3
Far upstream element-binding protein 3

1

17

High-throughput

0.479

High

1397038

CNO6L
CCR4-NOT transcription complex subunit 6-like

1

7

High-throughput

0.479

High

1406493

ATX2
Ataxin-2

1

3

High-throughput

0.479

High

1411306

LZTS2
Leucine zipper putative tumor suppressor 2

1

9

High-throughput

0.479

High

1418732

YTHD1
YTH domain-containing family protein 1

1

9

High-throughput

0.479

High

1419537

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

11

High-throughput

0.479

High

1429226

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

3

High-throughput

0.479

High

1437062

MOV10
Helicase MOV-10

1

11

High-throughput

0.479

High

1437066

DCP1A
mRNA-decapping enzyme 1A

1

4

High-throughput

0.479

High

1437067

4ET
Eukaryotic translation initiation factor 4E transporter

1

2

High-throughput

0.479

High

1437068

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

4

High-throughput

0.479

High

1437070

CNOT2
CCR4-NOT transcription complex subunit 2

1

4

High-throughput

0.479

High

1437071

MARK1
Serine/threonine-protein kinase MARK1

1

11

High-throughput

0.479

High

1437072

LIMD1
LIM domain-containing protein 1

1

7

Small-scale

0.479

High

1437074

XPO7
Exportin-7

1

3

High-throughput

0.479

High

1437075

CNOT7
CCR4-NOT transcription complex subunit 7

1

6

High-throughput

0.479

High

1437079

ZN346
Zinc finger protein 346

1

1

High-throughput

0.479

High

1437084

NINL
Ninein-like protein

1

6

High-throughput

0.479

High

1437085

R3HD2
R3H domain-containing protein 2

1

6

High-throughput

0.479

High

1437089

YTHD2
YTH domain-containing family protein 2

1

9

High-throughput

0.479

High

589720

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

284618

ECI2
Enoyl-CoA delta isomerase 2

1

2

High-throughput

0.445

High

942895

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

6

High-throughput

0.445

High

953108

ACTB
Actin, cytoplasmic 1

1

2

High-throughput

0.445

High

1023172

RBM10
RNA-binding protein 10

1

13

High-throughput

0.445

High

1024465

S25A3
Solute carrier family 25 member 3

1

12

High-throughput

0.445

High

1092649

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

2

High-throughput

0.445

High

1202031

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.445

High

1433199

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

6

High-throughput

0.445

High

1147685

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

1

High-throughput

0.437

High

1437086

AP3M1
AP-3 complex subunit mu-1

3

0

High-throughput

0.347

High

902317

ATP4B
Potassium-transporting ATPase subunit beta

1

0

High-throughput

0.282

High

464473

TSP1
Thrombospondin-1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025