HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	29721183
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005783 - endoplasmic reticulum GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment GO:0009986 - cell surface GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 654
+	Hs
		481060 HMGB1_HUMAN (1-174): 9.5e-45: 150: 100.00		HSP7C_HUMAN (26-637): 0: 914: 66.02
+	Hs
		186614 HMGB3_HUMAN (13-181): 1.46e-41: 141: 71.60		HSP7C_HUMAN (26-637): 0: 914: 66.02
+	Hs
		537046 SSRP1_HUMAN (53-164): 1.6e-28: 114: 37.50		HSP7C_HUMAN (26-637): 0: 914: 66.02
+	Hs
		318440 TOX4_HUMAN (91-163): 1.2e-27: 111: 38.36		HSP7C_HUMAN (26-637): 0: 914: 66.02
+	Rn
		237289 SOX10_RAT (4-98): 2.32e-21: 92.8: 14.74		HSP7C_RAT (26-637): 0: 914: 66.02
+	Hs
		537748 CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34		HSP7C_HUMAN (26-637): 0: 914: 66.02
+	Hs
		535432 CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34		BIP_HUMAN (19-654): 0: 913: 100.00
+	Hs
		536973 TFAM_HUMAN (95-186): 2.96e-09: 57.1: 17.39		HSP7C_HUMAN (26-637): 0: 914: 66.02
+	Hs
		931071 CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34		HSP72_HUMAN (25-636): 0: 903: 64.51
+	Sc
		597094 IXR1_YEAST (79-174): 2.27e-15: 75.9: 23.96		BIP_YEAST (22-638): 0: 798: 68.82