Protein: IXR1
Intrastrand cross-link recognition protein (Structure-specific recognition protein) (SSRP)

Gene: IXR1
Organism: Saccharomyces cerevisiae S288C
Interactions: 138
UniProt ID: P33417

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0001046 - core promoter sequence-specific DNA binding
GO:0003684 - damaged DNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

523503

HSP71
Heat shock protein SSA1

5

12

Small-scale

0.699

High

526302

HSP72
Heat shock protein SSA2

3

12

Small-scale

0.624

High

544334

SSB1
Ribosome-associated molecular chaperone SSB1

3

13

Small-scale

0.624

High

752951

IXR1
Intrastrand cross-link recognition protein

1

16

Small-scale

0.621

High

752996

SMT3
Ubiquitin-like protein SMT3

2

11

High-throughput

0.600

High

752986

ABF2
ARS-binding factor 2, mitochondrial

1

20

High-throughput

0.575

High

434971

RS3
Small ribosomal subunit protein uS3

2

3

Small-scale

0.571

High

684672

RL5
Large ribosomal subunit protein uL18

2

3

Small-scale

0.571

High

752983

ACT
Actin

2

6

Small-scale

0.571

High

359189

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

1

Small-scale

0.552

High

512352

RS6A
Small ribosomal subunit protein eS6A

2

4

Small-scale

0.533

High

752961

RS20
Small ribosomal subunit protein uS10

2

4

Small-scale

0.533

High

358172

ADH1
Alcohol dehydrogenase 1

2

1

Small-scale

0.521

High

365001

KPYK1
Pyruvate kinase 1

2

2

Small-scale

0.521

High

394413

EF1A
Elongation factor 1-alpha

2

4

Small-scale

0.521

High

427205

RLA0
Large ribosomal subunit protein uL10

2

6

Small-scale

0.521

High

747268

RSSA1
Small ribosomal subunit protein uS2A

2

9

High-throughput

0.521

High

752973

MPG1
Mannose-1-phosphate guanyltransferase

2

3

Small-scale

0.521

High

752976

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

4

Small-scale

0.481

High

752998

CMR1
DNA damage-binding protein CMR1

1

20

High-throughput

0.481

High

392495

HSP82
ATP-dependent molecular chaperone HSP82

1

5

Small-scale

0.479

High

403433

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

3

Small-scale

0.479

High

481568

HSP73
Heat shock protein SSA3

1

12

Small-scale

0.479

High

531678

RL4A
Large ribosomal subunit protein uL4A

1

4

Small-scale

0.479

High

575919

CYPH
Peptidyl-prolyl cis-trans isomerase

1

8

Small-scale

0.479

High

594291

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

4

High-throughput

0.479

High

645709

HSP74
Heat shock protein SSA4

1

12

Small-scale

0.479

High

752955

SPT10
Protein SPT10

1

1

High-throughput

0.479

High

752978

RL4B
Large ribosomal subunit protein uL4B

1

4

Small-scale

0.479

High

752982

RL15B
Large ribosomal subunit protein eL15B

1

2

Small-scale

0.479

High

752994

SCC1
Sister chromatid cohesion protein 1

1

3

High-throughput

0.479

High

752966

SAP1
Protein SAP1

1

5

High-throughput

0.464

High

439303

PDC1
Pyruvate decarboxylase isozyme 1

1

0

Small-scale

0.458

High

590592

HSP26
Heat shock protein 26

1

0

Small-scale

0.458

High

752984

GPD1
Glycerol-3-phosphate dehydrogenase [NAD(+)] 1

1

0

Small-scale

0.458

High

381049

H2B1
Histone H2B.1

1

20

High-throughput

0.445

High

381997

H4
Histone H4

1

13

High-throughput

0.445

High

402209

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

8

High-throughput

0.445

High

419678

H2A2
Histone H2A.2

1

20

High-throughput

0.445

High

597094

BIP
Endoplasmic reticulum chaperone BiP

1

8

High-throughput

0.445

High

647073

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

8

High-throughput

0.445

High

649943

SIN3
Transcriptional regulatory protein SIN3

1

3

High-throughput

0.445

High

721812

XPO1
Exportin-1

1

9

High-throughput

0.445

High

734406

BTAF1
TATA-binding protein-associated factor MOT1

1

20

High-throughput

0.445

High

743071

STH1
Nuclear protein STH1/NPS1

1

20

High-throughput

0.445

High

748122

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

2

High-throughput

0.445

High

751891

TFC4
Transcription factor tau 131 kDa subunit

1

4

High-throughput

0.445

High

752958

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

20

High-throughput

0.445

High

752959

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

20

High-throughput

0.445

High

752963

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

4

High-throughput

0.445

High

752967

SSB2
Ribosome-associated molecular chaperone SSB2

1

13

High-throughput

0.445

High

752974

RSC8
Chromatin structure-remodeling complex protein RSC8

1

13

High-throughput

0.445

High

752979

ITC1
Imitation switch two complex protein 1

1

4

High-throughput

0.445

High

752980

RSC1
Chromatin structure-remodeling complex subunit RSC1

1

20

High-throughput

0.445

High

752988

RUVB1
RuvB-like protein 1

1

9

High-throughput

0.445

High

752990

ARP9
Actin-like protein ARP9

1

11

High-throughput

0.445

High

752992

RSC3
Chromatin structure-remodeling complex protein RSC3

1

3

High-throughput

0.445

High

752993

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

20

High-throughput

0.445

High

752997

RUVB2
RuvB-like protein 2

1

9

High-throughput

0.445

High

359453

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

1

Small-scale

0.437

High

366989

ATPB
ATP synthase subunit beta, mitochondrial

1

8

Small-scale

0.437

High

367730

ENO1
Enolase 1

1

3

Small-scale

0.437

High

367937

ENO2
Enolase 2

1

3

Small-scale

0.437

High

368636

PMG1
Phosphoglycerate mutase 1

1

4

Small-scale

0.437

High

383109

RLA4
Large ribosomal subunit protein P2B

1

4

Small-scale

0.437

High

410034

RL25
Large ribosomal subunit protein uL23

1

3

Small-scale

0.437

High

417066

VDAC1
Non-selective voltage-gated ion channel 1

1

2

Small-scale

0.437

High

420907

PMA1
Plasma membrane ATPase 1

1

4

Small-scale

0.437

High

427554

RLA1
Large ribosomal subunit protein P1A

1

1

Small-scale

0.437

High

427685

RLA2
Large ribosomal subunit protein P2A

1

4

Small-scale

0.437

High

432535

RL7A
Large ribosomal subunit protein uL30A

1

5

Small-scale

0.437

High

434348

RL15A
Large ribosomal subunit protein eL15A

1

2

Small-scale

0.437

High

438810

CYSD
Homocysteine/cysteine synthase

1

1

Small-scale

0.437

High

441815

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.437

High

448518

RHO1
GTP-binding protein RHO1

1

11

Small-scale

0.437

High

452873

ATPA
ATP synthase subunit alpha, mitochondrial

1

8

Small-scale

0.437

High

454206

LEUC
3-isopropylmalate dehydratase

1

1

Small-scale

0.437

High

502949

RS22A
Small ribosomal subunit protein uS8A

1

4

Small-scale

0.437

High

503771

RL27A
Large ribosomal subunit protein eL27A

1

4

Small-scale

0.437

High

503905

RL27B
Large ribosomal subunit protein eL27B

1

4

Small-scale

0.437

High

511166

RL20B
Large ribosomal subunit protein eL20B

1

2

Small-scale

0.437

High

512917

RS8A
Small ribosomal subunit protein eS8A

1

4

High-throughput

0.437

High

513478

RL1A
Large ribosomal subunit protein uL1A

1

6

Small-scale

0.437

High

514552

RS18A
Small ribosomal subunit protein uS13A

1

4

High-throughput

0.437

High

515070

RL19B
Large ribosomal subunit protein eL19

1

2

Small-scale

0.437

High

557583

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

2

High-throughput

0.437

High

569957

RL3
Large ribosomal subunit protein uL3

1

4

Small-scale

0.437

High

579129

HSC82
ATP-dependent molecular chaperone HSC82

1

5

Small-scale

0.437

High

619344

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

7

Small-scale

0.437

High

624730

PMA2
Plasma membrane ATPase 2

1

4

Small-scale

0.437

High

674522

RS2
Small ribosomal subunit protein uS5

1

5

High-throughput

0.437

High

688854

RS5
Small ribosomal subunit protein uS7

1

4

Small-scale

0.437

High

689359

RS7A
Small ribosomal subunit protein eS7A

1

3

High-throughput

0.437

High

734056

EF2
Elongation factor 2

1

6

Small-scale

0.437

High

737364

EF1B
Elongation factor 1-beta

1

1

Small-scale

0.437

High

752952

RS3A1
Small ribosomal subunit protein eS1A

1

5

High-throughput

0.437

High

752954

TSA1
Peroxiredoxin TSA1

1

6

Small-scale

0.437

High

752964

HXT6
High-affinity hexose transporter HXT6

1

1

Small-scale

0.437

High

752965

HXT7
High-affinity hexose transporter HXT7

1

1

Small-scale

0.437

High

752968

RL13B
Large ribosomal subunit protein eL13B

1

2

Small-scale

0.437

High

752969

6P21
6-phosphofructo-2-kinase 1

1

5

Small-scale

0.437

High

752972

RL10
Large ribosomal subunit protein uL16

1

4

Small-scale

0.437

High

752975

RSSA2
Small ribosomal subunit protein uS2B

1

9

Small-scale

0.437

High

752977

RS12
Small ribosomal subunit protein eS12

1

3

Small-scale

0.437

High

752981

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

2

Small-scale

0.437

High

752989

RTN1
Reticulon-like protein 1

1

2

Small-scale

0.437

High

752995

RL7B
Large ribosomal subunit protein uL30B

1

5

Small-scale

0.437

High

752999

RS21B
Small ribosomal subunit protein eS21B

1

1

Small-scale

0.437

High

753000

RS22B
Small ribosomal subunit protein uS8B

1

4

Small-scale

0.437

High

486117

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

752962

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.426

High

752985

TBF1
Protein TBF1

1

0

High-throughput

0.426

High

438410

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

1

High-throughput

0.407

High

453519

PYR1
Multifunctional protein URA2

1

5

High-throughput

0.407

High

592146

VATB
V-type proton ATPase subunit B

1

8

High-throughput

0.407

High

701506

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

3

High-throughput

0.407

High

752953

GCN1
eIF-2-alpha kinase activator GCN1

1

6

High-throughput

0.407

High

752960

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.407

High

752970

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

3

High-throughput

0.407

High

752991

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

20

High-throughput

0.407

High

360878

COX6
Cytochrome c oxidase subunit 6, mitochondrial

1

0

Small-scale

0.249

Low

365596

PGK
Phosphoglycerate kinase

1

0

Small-scale

0.249

Low

368428

TPIS
Triosephosphate isomerase

1

0

Small-scale

0.249

Low

416411

HXKA
Hexokinase-1

1

0

Small-scale

0.249

Low

432313

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

Small-scale

0.249

Low

450438

CY1
Cytochrome c1, heme protein, mitochondrial

1

0

Small-scale

0.249

Low

534178

PCKA
Phosphoenolpyruvate carboxykinase

1

0

Small-scale

0.249

Low

572551

ALF
Fructose-bisphosphate aldolase

1

0

Small-scale

0.249

Low

621356

METK2
S-adenosylmethionine synthase 2

1

0

Small-scale

0.249

Low

678035

HSP30
30 kDa heat shock protein

1

0

Small-scale

0.249

Low

740043

VPP1
V-type proton ATPase subunit a, vacuolar isoform

1

0

Small-scale

0.249

Low

752956

PET10
Protein PET10

1

0

Small-scale

0.249

Low

752957

AHP1
Peroxiredoxin AHP1

1

0

Small-scale

0.249

Low

752971

FET4
Low-affinity Fe(2+) transport protein

1

0

Small-scale

0.249

Low

752987

MSC1
Meiotic sister chromatid recombination protein 1

1

0

Small-scale

0.249

Low

386655

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

677799

ILV6
Acetolactate synthase small subunit, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025