Protein: DCP2
m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc)

Gene: DCP2
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q8IU60

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000932 - P-body
GO:0004534 - 5'-3' RNA exonuclease activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1215883

DCP1A
mRNA-decapping enzyme 1A

14

3

Small-scale

0.986

High

1215857

DCP1B
mRNA-decapping enzyme 1B

6

3

Small-scale

0.950

High

1215884

PNRC2
Proline-rich nuclear receptor coactivator 2

3

0

Small-scale

0.796

High

1158972

EDC4
Enhancer of mRNA-decapping protein 4

9

2

Small-scale

0.756

High

1215869

EDC3
Enhancer of mRNA-decapping protein 3

5

4

Small-scale

0.718

High

1215867

RENT1
Regulator of nonsense transcripts 1

3

1

Small-scale

0.667

High

1036709

SQSTM
Sequestosome-1

4

0

High-throughput

0.664

High

802649

CRK
Adapter molecule crk

3

1

High-throughput

0.650

High

147766

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

3

0

High-throughput

0.638

High

884325

PCBP3
Poly(rC)-binding protein 3

3

0

High-throughput

0.638

High

984388

EF1A2
Elongation factor 1-alpha 2

3

0

High-throughput

0.638

High

1215895

COL10
Collectin-10

3

0

High-throughput

0.638

High

1053490

LRC32
Transforming growth factor beta activator LRRC32

2

0

High-throughput

0.602

High

640534

DDX6
Probable ATP-dependent RNA helicase DDX6

2

2

Small-scale

0.584

High

897772

ABCE1
ATP-binding cassette sub-family E member 1

2

1

Small-scale

0.584

High

1215855

DCP2
m7GpppN-mRNA hydrolase

1

1

Small-scale

0.575

High

1215881

RENT2
Regulator of nonsense transcripts 2

2

0

Small-scale

0.575

High

341278

FA9
Coagulation factor IX

2

1

High-throughput

0.574

High

742381

SYUA
Alpha-synuclein

2

0

High-throughput

0.547

High

585005

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.537

High

451489

CLCA
Clathrin light chain A

1

1

High-throughput

0.536

High

451702

CLCB
Clathrin light chain B

1

1

High-throughput

0.536

High

644285

TTP
mRNA decay activator protein ZFP36

1

1

Small-scale

0.536

High

802867

CRKL
Crk-like protein

1

1

High-throughput

0.536

High

497265

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

609944

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

High-throughput

0.513

High

750339

COIL
Coilin

1

0

High-throughput

0.513

High

896142

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.513

High

1215859

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

1215861

XXLT1
Xyloside xylosyltransferase 1

1

0

High-throughput

0.513

High

1215864

PPR35
Protein phosphatase 1 regulatory subunit 35

1

0

High-throughput

0.513

High

1215871

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.513

High

1215873

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

0

High-throughput

0.513

High

787518

MTOR
Serine/threonine-protein kinase mTOR

1

3

Small-scale

0.501

High

594579

PSB1
Proteasome subunit beta type-1

1

0

High-throughput

0.486

High

1050430

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.486

High

1215890

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.486

High

296562

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

1

High-throughput

0.479

High

539816

IDE
Insulin-degrading enzyme

1

1

High-throughput

0.479

High

959523

VIGLN
Vigilin

1

2

High-throughput

0.479

High

986525

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

1

High-throughput

0.479

High

991169

TISB
mRNA decay activator protein ZFP36L1

1

1

Small-scale

0.479

High

1198352

PATL1
Protein PAT1 homolog 1

1

3

Small-scale

0.479

High

1215893

TRRAP
Transformation/transcription domain-associated protein

1

3

High-throughput

0.479

High

305787

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

313081

AGM1
Phosphoacetylglucosamine mutase

1

0

High-throughput

0.458

High

335138

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.458

High

374491

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

437773

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

0

High-throughput

0.458

High

553114

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

568992

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.458

High

643766

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

0

High-throughput

0.458

High

720855

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

779699

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

782930

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.458

High

904815

1433G
14-3-3 protein gamma

1

0

High-throughput

0.458

High

929322

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

1066068

DPOD3
DNA polymerase delta subunit 3

1

0

High-throughput

0.458

High

1114127

TBB8
Tubulin beta-8 chain

1

0

High-throughput

0.458

High

1138099

ANGE2
Protein angel homolog 2

1

0

High-throughput

0.458

High

1161582

SYDM
Aspartate--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1187653

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

0

Small-scale

0.458

High

1215856

TRM2A
tRNA

1

0

High-throughput

0.458

High

1215860

RHG18
Rho GTPase-activating protein 18

1

0

High-throughput

0.458

High

1215862

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

High-throughput

0.458

High

1215866

DDX17
Probable ATP-dependent RNA helicase DDX17

1

0

Small-scale

0.458

High

1215868

KPBB
Phosphorylase b kinase regulatory subunit beta

1

0

High-throughput

0.458

High

1215872

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1215875

AP1M1
AP-1 complex subunit mu-1

1

0

High-throughput

0.458

High

1215876

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

1215877

REN3A
Regulator of nonsense transcripts 3A

1

0

Small-scale

0.458

High

1215878

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1215879

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1215880

ELP3
Elongator complex protein 3

1

0

High-throughput

0.458

High

1215885

INT7
Integrator complex subunit 7

1

0

High-throughput

0.458

High

1215887

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.458

High

1215891

FBX3
F-box only protein 3

1

0

High-throughput

0.458

High

1215892

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.458

High

1215894

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.458

High

1215858

XRN1
5'-3' exoribonuclease 1

1

2

Small-scale

0.445

High

1215874

GTPB2
GTP-binding protein 2

1

1

High-throughput

0.437

High

3539

NBDY
Negative regulator of P-body association

1

0

Small-scale

0.426

High

1215888

CNOT7
CCR4-NOT transcription complex subunit 7

1

0

Small-scale

0.426

High

1215882

SACA1
Sperm acrosome membrane-associated protein 1

3

0

High-throughput

0.347

High

259457

NIPS2
Protein NipSnap homolog 2

2

0

High-throughput

0.318

High

305273

NXPH3
Neurexophilin-3

2

0

High-throughput

0.318

High

1215889

GGT7
Glutathione hydrolase 7

2

0

High-throughput

0.318

High

319594

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

591228

ACM3
Muscarinic acetylcholine receptor M3

1

0

High-throughput

0.279

Low

1056212

I13R2
Interleukin-13 receptor subunit alpha-2

1

0

High-throughput

0.279

Low

1067917

PDCD1
Programmed cell death protein 1

1

0

High-throughput

0.279

Low

1085209

PRSS8
Prostasin

1

0

High-throughput

0.279

Low

1215863

LY65B
Lymphocyte antigen 6 complex locus protein G5b

1

0

High-throughput

0.279

Low

1215865

FNDC8
Fibronectin type III domain-containing protein 8

1

0

High-throughput

0.279

Low

750584

VKGC
Vitamin K-dependent gamma-carboxylase

1

0

High-throughput

0.249

Low

1158605

ARMX5
Armadillo repeat-containing X-linked protein 5

1

0

High-throughput

0.249

Low

1215870

SFXN2
Sideroflexin-2

1

0

High-throughput

0.249

Low

1215886

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024