HitPredict - High confidence protein-protein interactions

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: RAGE (Q15109)
Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)
Gene: AGER

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	25495026, 19727205, 24474694
Identification Methods	affinity chromatography technology, solid phase assay, surface plasmon resonance
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005769 - early endosome GO:0006954 - inflammatory response and 12 others more... GO:0009986 - cell surface GO:0031175 - neuron projection development GO:0032731 - positive regulation of interleukin-1 beta production GO:0032735 - positive regulation of interleukin-12 production GO:0032755 - positive regulation of interleukin-6 production GO:0032760 - positive regulation of tumor necrosis factor production GO:0042104 - positive regulation of activated T cell proliferation GO:0046330 - positive regulation of JNK cascade GO:0070374 - positive regulation of ERK1 and ERK2 cascade GO:0071639 - positive regulation of monocyte chemotactic protein-1 production GO:1901224 - positive regulation of non-canonical NF-kappaB signal transduction GO:2001200 - positive regulation of dendritic cell differentiation
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	215
Hs

1	404

Service provided by Combinatics, Japan

Last updated: 11Aug2025