Protein: HMGB1
High mobility group protein B1 (High mobility group protein 1) (HMG-1)

Gene: HMGB1
Organism: Mus musculus
Interactions: 32
UniProt ID: P63158

Gene Ontology (top 5):
GO:0000400 - four-way junction DNA binding
GO:0000401 - open form four-way junction DNA binding
GO:0000402 - crossed form four-way junction DNA binding
GO:0000405 - bubble DNA binding
GO:0000793 - condensed chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

991150

RAGE
Advanced glycosylation end product-specific receptor

1

4

Small-scale

0.647

High

991156

HAVR2
Hepatitis A virus cellular receptor 2 homolog

1

0

Small-scale

0.537

High

382463

P53
Cellular tumor antigen p53

1

9

Small-scale

0.536

High

561634

RB
Retinoblastoma-associated protein

1

3

Small-scale

0.536

High

653757

TTP
mRNA decay activator protein ZFP36

1

4

Small-scale

0.536

High

988922

TLE5
TLE family member 5

1

15

Small-scale

0.536

High

991145

RELB
Transcription factor RelB

1

16

Small-scale

0.536

High

991151

TLE1
Transducin-like enhancer protein 1

1

20

Small-scale

0.536

High

991161

MECP2
Methyl-CpG-binding protein 2

1

20

Small-scale

0.536

High

991153

HDAC4
Histone deacetylase 4

1

18

High-throughput

0.536

High

991160

SRBP1
Sterol regulatory element-binding protein 1

1

20

Small-scale

0.534

High

312653

BECN1
Beclin-1

1

2

Small-scale

0.500

High

108606

G3X9H5
Huntingtin

1

5

High-throughput

0.479

High

613723

LYAM1
L-selectin

1

3

Small-scale

0.479

High

821236

SDF1
Stromal cell-derived factor 1

1

1

Small-scale

0.479

High

846138

CDX2
Homeobox protein CDX-2

1

20

High-throughput

0.479

High

915279

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

8

High-throughput

0.479

High

927687

ATX1
Ataxin-1

1

15

High-throughput

0.479

High

991146

STING
Stimulator of interferon genes protein

1

2

High-throughput

0.479

High

991147

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

11

High-throughput

0.479

High

991149

KLF4
Krueppel-like factor 4

1

19

Small-scale

0.479

High

991152

TFE3
Transcription factor E3

1

20

High-throughput

0.479

High

991157

TLR9
Toll-like receptor 9

1

6

Small-scale

0.479

High

991158

TLR4
Toll-like receptor 4

1

5

Small-scale

0.479

High

991159

TLR2
Toll-like receptor 2

1

6

Small-scale

0.479

High

666648

CD24
Signal transducer CD24

1

0

Small-scale

0.458

High

991148

CLU
Clustered mitochondria protein homolog

1

0

High-throughput

0.458

High

703227

APEX1
DNA repair nuclease/redox regulator APEX1

1

3

Small-scale

0.445

High

814588

FEN1
Flap endonuclease 1

1

3

Small-scale

0.445

High

991154

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

6

High-throughput

0.437

High

522158

BCL2
Apoptosis regulator Bcl-2

1

0

Small-scale

0.426

High

991155

MT21E
Protein-lysine methyltransferase METTL21E

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025