HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019904 - protein domain specific binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 372 Hs			1 1319
+	Hs
		650635 ROA2_HUMAN (1-320): 2.13e-56: 189: 58.44		NEDD4_HUMAN (1-1319): 0: 1940: 100.00
+	Hs
		1120374 HNRPD_HUMAN (2-99): 4.16e-18: 86.4: 24.00		HECW2_HUMAN (387-1317): 0: 696: 28.91
+	Hs
		650830 ROA2_HUMAN (1-320): 2.13e-56: 189: 58.44		HUWE1_HUMAN (799-1317): 4.45e-169: 562: 35.32
+	Hs
		1280435 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		HUWE1_HUMAN (799-1317): 4.45e-169: 562: 35.32
+	Hs
		1280467 RBM4_HUMAN (104-187): 6.5e-11: 65.2: 22.35		HUWE1_HUMAN (799-1317): 4.45e-169: 562: 35.32
+	Hs
		485404 ROA1_HUMAN (1-372): 6.83e-64: 210: 100.00		WWP1_HUMAN (385-707): 7.2e-57: 216: 17.48
+	Hs
		131684 ROA1_HUMAN (1-372): 6.83e-64: 210: 100.00		WWP2_HUMAN (461-799): 1.62e-40: 164: 18.79
+	Hs
		131841 ROA3_HUMAN (7-202): 1.05e-56: 191: 85.71		WWP2_HUMAN (461-799): 1.62e-40: 164: 18.79
+	Hs
		131733 ROA2_HUMAN (1-320): 2.13e-56: 189: 58.44		WWP2_HUMAN (461-799): 1.62e-40: 164: 18.79
+	Hs
		485429 ROA1_HUMAN (1-372): 6.83e-64: 210: 100.00		SMUF1_HUMAN (483-719): 1.25e-23: 110: 15.71
+	Hs
		909705 ROA3_HUMAN (7-202): 1.05e-56: 191: 85.71		SMUF1_HUMAN (483-719): 1.25e-23: 110: 15.71
+	Hs
		650969 ROA2_HUMAN (1-320): 2.13e-56: 189: 58.44		SMUF1_HUMAN (483-719): 1.25e-23: 110: 15.71
+	Hs
		132027 HNRPD_HUMAN (2-99): 4.16e-18: 86.4: 24.00		WWP2_HUMAN (461-799): 1.62e-40: 164: 18.79
+	Hs
		1406857 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		SMUF1_HUMAN (483-719): 1.25e-23: 110: 15.71
+	Hs
		132224 DAZP1_HUMAN (3-87): 1.54e-15: 79.4: 31.77		WWP2_HUMAN (461-799): 1.62e-40: 164: 18.79
+	Hs
		132010 PABP4_HUMAN (102-193): 4.58e-15: 78.7: 15.05		WWP2_HUMAN (461-799): 1.62e-40: 164: 18.79
+	Hs
		1120288 HNRPD_HUMAN (2-99): 4.16e-18: 86.4: 24.00		ITCH_HUMAN (305-642): 6.68e-25: 114: 14.82
+	Hs
		1120348 HNRPD_HUMAN (2-99): 4.16e-18: 86.4: 24.00		SMUF1_HUMAN (483-719): 1.25e-23: 110: 15.71
+	Hs
		1389454 DAZP1_HUMAN (3-87): 1.54e-15: 79.4: 31.77		ITCH_HUMAN (305-642): 6.68e-25: 114: 14.82