HitPredict

Interactor 1: IF4A (P10081)
ATP-dependent RNA helicase eIF4A (EC 3.6.4.13) (Eukaryotic initiation factor 4A) (eIF-4A) (Stimulator factor I 37 kDa component) (Translation initiation factor 1/2) (p37)
Gene: TIF1

Interactor 2: XPO1 (P30822)
Exportin-1 (Chromosome region maintenance protein 1) (Karyopherin-124)
Gene: CRM1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	16429126, 37968396
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 395 Sc			1 1084
+	Sc
		676457 FAL1_YEAST (19-393): 1.59e-147: 425: 56.73		XPO1_YEAST (1-1084): 0: 833: 100.00
+	Hs
		163081 DDX17_HUMAN (1-395): 1.81e-132: 398: 31.85		XPO1_HUMAN (3-1084): 0: 854: 46.40
+	Xl
		1155771 Q9I8S3_XENLA (2-394): 6.91e-134: 398: 30.35		Q6NS03_XENLA (3-1084): 0: 852: 46.77
+	Hs
		162389 DDX5_HUMAN (1-394): 2.34e-132: 394: 31.27		XPO1_HUMAN (3-1084): 0: 854: 46.40
+	Xl
		1146043 Q66JB0_XENLA (1-395): 4.54e-132: 393: 32.18		Q6NS03_XENLA (3-1084): 0: 852: 46.77
+	Xl
		1155738 Q801P9_XENLA (2-394): 2.94e-132: 393: 30.35		Q6NS03_XENLA (3-1084): 0: 852: 46.77
+	Hs
		133768 DDX3X_HUMAN (3-393): 2.68e-129: 388: 29.95		XPO1_HUMAN (3-1084): 0: 854: 46.40
+	Sc
		624211 DBP1_YEAST (3-393): 3.17e-128: 383: 29.93		XPO1_YEAST (1-1084): 0: 833: 100.00
+	Sc
		415913 DED1_YEAST (3-395): 1.27e-125: 376: 30.19		XPO1_YEAST (1-1084): 0: 833: 100.00
+	Xl
		873114 DDX6_XENLA (23-390): 2.08e-90: 282: 39.73		Q6NS03_XENLA (3-1084): 0: 852: 46.77
+	Sc
		676058 DHH1_YEAST (24-390): 2.1e-96: 298: 43.48		XPO1_YEAST (1-1084): 0: 833: 100.00
+	Mm
		892962 IF4A1_MOUSE (9-394): 1.03e-170: 484: 66.24		XPO7_MOUSE (11-1030): 1.87e-146: 468: 13.68
+	Mm
		496132 IF4A2_MOUSE (8-394): 2.32e-170: 483: 65.04		XPO7_MOUSE (11-1030): 1.87e-146: 468: 13.68
+	Mm
		1143000 DDX5_MOUSE (1-394): 1.42e-133: 397: 31.27		XPO7_MOUSE (11-1030): 1.87e-146: 468: 13.68
+	Mm
		1119391 DDX17_MOUSE (1-395): 9.25e-133: 396: 31.85		XPO7_MOUSE (11-1030): 1.87e-146: 468: 13.68
+	Mm
		558500 DDX3L_MOUSE (3-393): 2.22e-129: 388: 29.95		XPO7_MOUSE (11-1030): 1.87e-146: 468: 13.68
+	Mm
		1265057 IF4A3_MOUSE (3-394): 7e-126: 370: 61.32		XPO7_MOUSE (11-1030): 1.87e-146: 468: 13.68