Interactor 1: IF4A (P10081)
ATP-dependent RNA helicase eIF4A (EC 3.6.4.13) (Eukaryotic initiation factor 4A) (eIF-4A) (Stimulator factor I 37 kDa component) (Translation initiation factor 1/2) (p37)
Gene: TIF1

Interactor 2: IF4F1 (P39935)
Eukaryotic initiation factor 4F subunit p150 (eIF-4F p150) (eIF4F p150) (Translation initiation factor 4(4)-F(6) subunit gamma(3) protein 1) (eIF4G1) (mRNA cap-binding protein complex subunit p150)
Gene: TIF4631

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 18606994, 10480875, 11805826, 11805837, 10409745, 16429126, 27858515, 29987188, 37968396, 21795399, 16554755, 27494274, 29438499, 12810920, 23184954, 22851688, 14759368
Identification Methods molecular sieving, surface plasmon resonance, affinity chromatography technology, pull down, x-ray crystallography, dynamic light scattering, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains DEAD~MIF4G, Helicase_C~MIF4G
Common GO terms GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0005737 - cytoplasm
GO:0005840 - ribosome
GO:0006413 - translational initiation
and 4 others

more...

Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 395
Sc

1 952
+ Sc
+ Sc
+ Sc
+ Sc
+ Dm
+ Sc
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ At
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

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Last updated: 15 Jul 2024