HitPredict

Interactor 1: RAP2A (P10114)
Ras-related protein Rap-2a (EC 3.6.5.2) (RbBP-30)
Gene: RAP2A

Interactor 2: GDS1 (P52306)
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)
Gene: RAP1GDS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Arm~Ras
Common GO terms	GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 183 Hs			1 607
+	Hs
		854083 RAP2B_HUMAN (1-182): 2.01e-82: 243: 91.21		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854088 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854154 RAP2C_HUMAN (1-183): 2.97e-81: 240: 91.26		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854082 RAP1B_HUMAN (1-182): 4.24e-79: 234: 60.66		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854133 RAB1B_HUMAN (4-178): 1.24e-76: 229: 34.09		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		506444 RALB_HUMAN (4-174): 3.73e-49: 159: 45.93		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854121 DIRA2_HUMAN (3-161): 2.6e-49: 159: 51.25		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		349206 RASH_HUMAN (1-180): 3.16e-48: 156: 46.49		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Xl
		292764 RALBB_XENLA (4-174): 2.26e-49: 160: 45.93		GDS1A_XENLA (1-607): 0: 899: 85.50
+	Xl
		292765 RALBA_XENLA (4-174): 1.09e-49: 160: 45.93		GDS1A_XENLA (1-607): 0: 899: 85.50
+	Dm
		51787 O96692_DROME (1-177): 8.99e-77: 229: 69.66		GDS1_DROME (62-536): 0: 540: 31.27
+	Dm
		51795 Q962I2_DROME (4-177): 4.48e-50: 161: 43.17		GDS1_DROME (62-536): 0: 540: 31.27
+	Dm
		51789 RALA_DROME (4-164): 1.75e-49: 160: 46.58		GDS1_DROME (62-536): 0: 540: 31.27