HitPredict

Interactor 1: GRAB (P10144)
Granzyme B (EC 3.4.21.79) (C11) (CTLA-1) (Cathepsin G-like 1) (CTSGL1) (Cytotoxic T-lymphocyte proteinase 2) (Lymphocyte protease) (Fragmentin-2) (Granzyme-2) (Human lymphocyte protein) (HLP) (SECT) (T-cell serine protease 1-3E)
Gene: GZMB

Interactor 2: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.60	0.569

Property	Details
Experiments	8760815
Identification Methods	enzymatic study, protease assay
Interaction Type	direct interaction, protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 247 Hs			1 732
+	Hs
		524969 TM11B_HUMAN (11-244): 6.41e-92: 278: 23.48		XRCC5_HUMAN (1-732): 0: 755: 100.00
+	Hs
		519843 GRAA_HUMAN (13-223): 1.89e-49: 164: 43.98		XRCC5_HUMAN (1-732): 0: 755: 100.00
+	Hs
		486147 GRAB_HUMAN (1-247): 1.38e-105: 307: 100.00		XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49
+	Hs
		519842 GRAA_HUMAN (13-223): 1.89e-49: 164: 43.98		XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49