HitPredict

Interactor 1: ARAF (P10398)
Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks)
Gene: ARAF

Interactor 2: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	25852190, 29777862
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 606 Hs			1 803
+	Hs
		538082 BRAF_HUMAN (3-604): 0: 546: 56.68		ENPL_HUMAN (1-803): 0: 1073: 100.00
+	Hs
		373626 RAF1_HUMAN (13-606): 0: 534: 60.53		ENPL_HUMAN (1-803): 0: 1073: 100.00
+	Mm
		435915 BRAF_MOUSE (3-604): 0: 542: 55.81		ENPL_MOUSE (1-803): 0: 1062: 96.64
+	Hs
		437832 ARAF_HUMAN (1-606): 0: 579: 100.00		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431459 ARAF_HUMAN (1-606): 0: 579: 100.00		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		432156 Q96II5_HUMAN (1-606): 0: 573: 99.51		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Gg
		435893 BRAF_CHICK (3-604): 0: 542: 56.20		ENPL_CHICK (21-803): 0: 1006: 90.29
+	Hs
		437860 BRAF_HUMAN (3-604): 0: 546: 56.68		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431496 BRAF_HUMAN (3-604): 0: 546: 56.68		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		373549 RAF1_HUMAN (13-606): 0: 534: 60.53		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Gg
		513713 BRAF_CHICK (3-604): 0: 542: 56.20		HS90A_CHICK (60-783): 0: 986: 46.13
+	Mm
		432406 BRAF_MOUSE (3-604): 0: 542: 55.81		HS90A_MOUSE (60-783): 0: 985: 45.28
+	Hs
		373543 RAF1_HUMAN (13-606): 0: 534: 60.53		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Dm
		365432 KRAF1_DROME (5-605): 2.05e-167: 496: 42.18		HSP83_DROME (69-783): 0: 981: 45.74
+	Rn
		88624 D3ZHL1_RAT (50-606): 1.21e-128: 401: 25.66		HS90A_RAT (60-783): 0: 988: 45.28
+	Hs
		438332 KSR1_HUMAN (50-606): 7.14e-122: 384: 24.24		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		432033 KSR1_HUMAN (50-606): 7.14e-122: 384: 24.24		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		433218 YES_HUMAN (289-568): 3.31e-104: 327: 31.34		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431433 YES_HUMAN (289-568): 3.31e-104: 327: 31.34		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Zm
		8229 A0A1D6ELX5_MAIZE (94-575): 1.7e-123: 384: 25.41		A0A1D6LMW9_MAIZE (14-781): 0: 889: 46.68