HitPredict

Interactor 1: UCHL1 (P09936)
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)
Gene: UCHL1

Interactor 2: UBP15 (Q9Y4E8)
Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4)
Gene: USP15

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	22626734
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004197 - cysteine-type endopeptidase activity GO:0004843 - cysteine-type deubiquitinase activity GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0016579 - protein deubiquitination
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 223 Hs			1 981
+	Hs
		583909 UCHL3_HUMAN (2-222): 3.84e-101: 294: 54.43		UBP15_HUMAN (1-981): 0: 867: 100.00
+	Hs
		1491400 UCHL5_HUMAN (2-220): 6.64e-99: 292: 21.68		UBP15_HUMAN (1-981): 0: 867: 100.00
+	Hs
		1364730 BAP1_HUMAN (3-220): 6.72e-78: 249: 22.27		UBP15_HUMAN (1-981): 0: 867: 100.00
+	Hs
		907513 BAP1_HUMAN (3-220): 6.72e-78: 249: 22.27		UBP11_HUMAN (9-942): 0: 680: 44.29
+	Hs
		488425 UCHL1_HUMAN (1-223): 2.39e-103: 299: 100.00		UBP8_HUMAN (609-930): 3.75e-61: 229: 27.16
+	Hs
		488567 UCHL1_HUMAN (1-223): 2.39e-103: 299: 100.00		UBP21_HUMAN (582-935): 3.53e-62: 223: 22.55
+	Hs
		583904 UCHL3_HUMAN (2-222): 3.84e-101: 294: 54.43		UBP21_HUMAN (582-935): 3.53e-62: 223: 22.55
+	Hs
		288478 BAP1_HUMAN (3-220): 6.72e-78: 249: 22.27		UBP2_HUMAN (616-935): 7.14e-63: 226: 22.98
+	Hs
		1364669 BAP1_HUMAN (3-220): 6.72e-78: 249: 22.27		UBP21_HUMAN (582-935): 3.53e-62: 223: 22.55