Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.984

The method score is based on:

Property Details
Experiments 9353289, 26269332, 27460788, 19654187, 16735465, 27070645, 33972400, 34719765, 36634849, 32812023, 35063084, 17535890, 26436840, 30158706, 16446437, 30274285, 30894745, 30276465
Identification Methods pull down, affinity chromatography technology, protein complementation assay, proximity labelling technology, anti bait coimmunoprecipitation, atomic force microscopy, transmission electron microscopy, fluorescence microscopy, comigration in sds page, 3D electron microscopy and 2 others

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Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Tubulin-binding~Tubulin-binding
Common GO terms GO:0000226 - microtubule cytoskeleton organization
GO:0001774 - microglial cell activation
GO:0003677 - DNA binding
GO:0003680 - minor groove of adenine-thymine-rich DNA binding
GO:0003690 - double-stranded DNA binding
and 98 others

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Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 758
Hs

1 758
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024