Protein: C1TC
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]

Gene: C1TC, ADE3
Organism: Saccharomyces cerevisiae S288C
Interactions: 71
UniProt ID: P07245

Gene Ontology (top 5):
GO:0000105 - L-histidine biosynthetic process
GO:0004329 - formate-tetrahydrofolate ligase activity
GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity
GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

452544

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

6

Small-scale

0.691

High

452546

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

6

High-throughput

0.665

High

452551

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.601

High

452579

TM108
Protein TMA108

2

1

High-throughput

0.601

High

452547

RL2A
Large ribosomal subunit protein uL2A

2

1

High-throughput

0.584

High

452553

CAF20
Cap-associated protein CAF20

2

1

High-throughput

0.584

High

452556

HSC82
ATP-dependent molecular chaperone HSC82

2

7

High-throughput

0.584

High

452564

RL16A
Large ribosomal subunit protein uL13A

2

2

High-throughput

0.584

High

452581

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.584

High

452565

TF2B
Transcription initiation factor IIB

2

2

High-throughput

0.576

High

452549

HSP71
Heat shock protein SSA1

2

7

High-throughput

0.552

High

452568

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.536

High

452569

PTK1
Serine/threonine-protein kinase PTK1/STK1

1

3

High-throughput

0.536

High

452583

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.536

High

452595

GCN5
Histone acetyltransferase GCN5

1

4

High-throughput

0.536

High

452545

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

452559

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.513

High

452560

FKBP
FK506-binding protein 1

1

0

High-throughput

0.513

High

452561

UBA1
Ubiquitin-activating enzyme E1 1

1

0

High-throughput

0.493

High

383051

RLA4
Large ribosomal subunit protein P2B

1

3

High-throughput

0.479

High

392007

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.479

High

427071

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.479

High

438559

SC160
Protein SCP160

1

1

High-throughput

0.479

High

452548

RL18B
Large ribosomal subunit protein eL18B

1

1

High-throughput

0.479

High

452554

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

452557

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

452563

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

452566

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

452575

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

452576

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

452577

ARB1
ABC transporter ATP-binding protein ARB1

1

1

Small-scale

0.479

High

452584

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.479

High

452585

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.479

High

452588

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

452589

PESC
Pescadillo homolog

1

1

High-throughput

0.479

High

452590

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

High-throughput

0.479

High

452592

RL21A
Large ribosomal subunit protein eL21A

1

2

High-throughput

0.479

High

452594

TOM1
E3 ubiquitin-protein ligase TOM1

1

6

High-throughput

0.479

High

452597

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.479

High

452599

VMS1
tRNA endonuclease VMS1

1

1

High-throughput

0.479

High

452600

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

452602

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

452605

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.479

High

452606

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.479

High

416340

HXKA
Hexokinase-1

1

0

High-throughput

0.458

High

452552

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

452555

CPYI
Carboxypeptidase Y inhibitor

1

0

Small-scale

0.458

High

452562

KCC2
Calcium/calmodulin-dependent protein kinase II

1

0

High-throughput

0.458

High

452572

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

High-throughput

0.458

High

452574

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

452580

INP51
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51

1

0

High-throughput

0.458

High

452593

COFI
Cofilin

1

0

High-throughput

0.458

High

452598

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

452603

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.458

High

452604

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

394110

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

452550

HSP72
Heat shock protein SSA2

1

7

High-throughput

0.445

High

452573

SSZ1
Ribosome-associated complex subunit SSZ1

1

5

High-throughput

0.445

High

452578

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

452587

RL4B
Large ribosomal subunit protein uL4B

1

2

High-throughput

0.445

High

427638

RLA2
Large ribosomal subunit protein P2A

1

3

High-throughput

0.437

High

452570

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

452582

MID1
Stretch-activated cation channel MID1

1

1

Small-scale

0.437

High

452591

SAM50
Sorting assembly machinery 50 kDa subunit

1

2

High-throughput

0.437

High

452558

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.426

High

452571

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.426

High

452567

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

452586

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

452596

PEX29
Peroxisomal membrane protein PEX29

1

0

Small-scale

0.249

Low

452601

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025