Protein: C1TM
C-1-tetrahydrofolate synthase, mitochondrial (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]

Gene: C1TM, MIS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 220
UniProt ID: P09440

Gene Ontology (top 5):
GO:0004329 - formate-tetrahydrofolate ligase activity
GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity
GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

452546

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

6

High-throughput

0.665

High

481989

ZUO1
Zuotin

3

2

High-throughput

0.662

High

482020

IF2P
Eukaryotic translation initiation factor 5B

3

2

High-throughput

0.662

High

482001

GBLP
Small ribosomal subunit protein RACK1

3

4

High-throughput

0.656

High

481946

RL2A
Large ribosomal subunit protein uL2A

3

1

High-throughput

0.640

High

454782

RS19A
Small ribosomal subunit protein eS19A

3

1

High-throughput

0.633

High

432949

RL6B
Large ribosomal subunit protein eL6B

2

1

High-throughput

0.611

High

433111

RL17A
Large ribosomal subunit protein uL22A

2

1

High-throughput

0.611

High

481969

RS3A2
Small ribosomal subunit protein eS1B

2

2

High-throughput

0.611

High

482010

SSZ1
Ribosome-associated complex subunit SSZ1

2

5

High-throughput

0.611

High

482066

BRE5
UBP3-associated protein BRE5

2

2

High-throughput

0.611

High

481996

AP1B1
AP-1 complex subunit beta-1

2

0

High-throughput

0.602

High

482060

LSG1
Large subunit GTPase 1

2

0

High-throughput

0.595

High

481985

FUN30
ATP-dependent helicase FUN30

2

2

High-throughput

0.588

High

481977

RL5
Large ribosomal subunit protein uL18

2

0

High-throughput

0.585

High

482038

RL10
Large ribosomal subunit protein uL16

2

0

High-throughput

0.585

High

149498

RS9A
Small ribosomal subunit protein uS4A

2

1

High-throughput

0.584

High

433358

RL26A
Large ribosomal subunit protein uL24A

2

1

High-throughput

0.584

High

481936

RL31A
Large ribosomal subunit protein eL31A

2

1

High-throughput

0.584

High

481947

RL18B
Large ribosomal subunit protein eL18B

2

1

High-throughput

0.584

High

481979

RL16A
Large ribosomal subunit protein uL13A

2

2

High-throughput

0.584

High

481994

RS3A1
Small ribosomal subunit protein eS1A

2

2

High-throughput

0.584

High

481938

HSP77
Import motor subunit, mitochondrial

2

5

High-throughput

0.571

High

481964

HSC82
ATP-dependent molecular chaperone HSC82

2

7

High-throughput

0.571

High

481992

RSSA1
Small ribosomal subunit protein uS2A

2

1

High-throughput

0.571

High

481993

HSP78
Heat shock protein 78, mitochondrial

2

1

High-throughput

0.571

High

482054

RL4B
Large ribosomal subunit protein uL4B

2

2

High-throughput

0.571

High

481960

ERF1
Eukaryotic peptide chain release factor subunit 1

2

0

High-throughput

0.563

High

383429

RS17A
Small ribosomal subunit protein eS17A

2

0

High-throughput

0.559

High

409850

RL25
Large ribosomal subunit protein uL23

2

0

High-throughput

0.559

High

434710

RS3
Small ribosomal subunit protein uS3

2

0

High-throughput

0.559

High

435681

RS13
Small ribosomal subunit protein uS15

2

0

High-throughput

0.559

High

441618

RS14A
Small ribosomal subunit protein uS11A

2

0

High-throughput

0.559

High

481943

RS6A
Small ribosomal subunit protein eS6A

2

0

High-throughput

0.559

High

481944

RS8A
Small ribosomal subunit protein eS8A

2

0

High-throughput

0.559

High

427080

RLA0
Large ribosomal subunit protein uL10

2

1

High-throughput

0.558

High

481955

HSP72
Heat shock protein SSA2

2

7

High-throughput

0.552

High

481958

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.552

High

481956

RLA3
Large ribosomal subunit protein P1B

2

1

High-throughput

0.549

High

481973

HAL4
Serine/threonine-protein kinase HAL4/SAT4

1

1

High-throughput

0.536

High

482022

KC13
Casein kinase I homolog 3

1

1

High-throughput

0.536

High

482048

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

3

High-throughput

0.536

High

482075

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

482013

NACA
Nascent polypeptide-associated complex subunit alpha

2

1

High-throughput

0.521

High

481999

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.513

High

482003

YPK3
Serine/threonine-protein kinase YPK3

1

0

High-throughput

0.513

High

482084

PKH3
Serine/threonine-protein kinase PKH3

1

0

High-throughput

0.513

High

154110

RL36B
Large ribosomal subunit protein eL36B

1

1

High-throughput

0.479

High

383053

RLA4
Large ribosomal subunit protein P2B

1

3

High-throughput

0.479

High

392050

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.479

High

409657

RL24A
Large ribosomal subunit protein eL24A

1

1

High-throughput

0.479

High

432443

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.479

High

432768

RL9A
Large ribosomal subunit protein uL6A

1

1

High-throughput

0.479

High

433941

RL33A
Large ribosomal subunit protein eL33A

1

1

High-throughput

0.479

High

434116

RL36A
Large ribosomal subunit protein eL36A

1

1

High-throughput

0.479

High

434481

RL22A
Large ribosomal subunit protein eL22A

1

1

High-throughput

0.479

High

435489

RS9B
Small ribosomal subunit protein uS4B

1

1

High-throughput

0.479

High

455350

RS19B
Small ribosomal subunit protein eS19B

1

1

High-throughput

0.479

High

481931

RS25B
Small ribosomal subunit protein eS25B

1

1

High-throughput

0.479

High

481934

RL27A
Large ribosomal subunit protein eL27A

1

1

High-throughput

0.479

High

481935

RL27B
Large ribosomal subunit protein eL27B

1

1

High-throughput

0.479

High

481937

RL31B
Large ribosomal subunit protein eL31B

1

1

High-throughput

0.479

High

481948

RS16B
Small ribosomal subunit protein uS9B

1

2

High-throughput

0.479

High

481957

RL4A
Large ribosomal subunit protein uL4A

1

2

High-throughput

0.479

High

481963

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

481967

RL8A
Large ribosomal subunit protein eL8A

1

1

High-throughput

0.479

High

481968

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

481970

RL24B
Large ribosomal subunit protein eL24B

1

1

High-throughput

0.479

High

481972

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

481980

RL16B
Large ribosomal subunit protein uL13B

1

2

High-throughput

0.479

High

481981

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.479

High

481984

RL8B
Large ribosomal subunit protein eL8B

1

1

High-throughput

0.479

High

481986

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

481998

RL14A
Large ribosomal subunit protein eL14A

1

1

High-throughput

0.479

High

482009

RL14B
Large ribosomal subunit protein eL14B

1

1

High-throughput

0.479

High

482017

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

482018

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

482024

ARB1
ABC transporter ATP-binding protein ARB1

1

1

Small-scale

0.479

High

482029

RL13B
Large ribosomal subunit protein eL13B

1

1

High-throughput

0.479

High

482033

RL34B
Large ribosomal subunit protein eL34B

1

1

High-throughput

0.479

High

482036

RL33B
Large ribosomal subunit protein eL33B

1

1

High-throughput

0.479

High

482045

RSSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.479

High

482047

RL17B
Large ribosomal subunit protein uL22B

1

1

High-throughput

0.479

High

482050

RS7B
Small ribosomal subunit protein eS7B

1

2

High-throughput

0.479

High

482052

RL37A
Large ribosomal subunit protein eL37A

1

1

High-throughput

0.479

High

482056

RL9B
Large ribosomal subunit protein uL6B

1

1

High-throughput

0.479

High

482057

RL37B
Large ribosomal subunit protein eL37B

1

1

High-throughput

0.479

High

482061

RL26B
Large ribosomal subunit protein uL24B

1

1

High-throughput

0.479

High

482063

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

482069

SAM50
Sorting assembly machinery 50 kDa subunit

1

2

High-throughput

0.479

High

482072

RL22B
Large ribosomal subunit protein eL22B

1

1

High-throughput

0.479

High

482073

RL34A
Large ribosomal subunit protein eL34A

1

1

High-throughput

0.479

High

482074

NUM1
Nuclear migration protein NUM1

1

2

High-throughput

0.479

High

482077

RL6A
Large ribosomal subunit protein eL6A

1

1

High-throughput

0.479

High

482079

RL21A
Large ribosomal subunit protein eL21A

1

2

High-throughput

0.479

High

482080

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

482088

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

482089

VMS1
tRNA endonuclease VMS1

1

1

High-throughput

0.479

High

482102

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

482104

CHS5
Chitin biosynthesis protein CHS5

1

1

High-throughput

0.479

High

482105

RL7B
Large ribosomal subunit protein uL30B

1

1

High-throughput

0.479

High

482107

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.479

High

482108

RL21B
Large ribosomal subunit protein eL21B

1

2

High-throughput

0.479

High

482109

RL13A
Large ribosomal subunit protein eL13A

1

1

High-throughput

0.479

High

482112

RS25A
Small ribosomal subunit protein eS25A

1

1

High-throughput

0.479

High

382790

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

403309

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

Small-scale

0.458

High

414971

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.458

High

434210

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.458

High

434293

RL15A
Large ribosomal subunit protein eL15A

1

0

High-throughput

0.458

High

481932

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

481933

RS28B
Small ribosomal subunit protein eS28B

1

0

High-throughput

0.458

High

481939

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.458

High

481940

RL43B
Large ribosomal subunit protein eL43B

1

0

High-throughput

0.458

High

481941

RS30A
Small ribosomal subunit protein eS30A

1

0

High-throughput

0.458

High

481942

RS4A
Small ribosomal subunit protein eS4A

1

0

High-throughput

0.458

High

481945

RL1A
Large ribosomal subunit protein uL1A

1

0

High-throughput

0.458

High

481949

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.458

High

481950

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

481951

RL19B
Large ribosomal subunit protein eL19

1

0

High-throughput

0.458

High

481952

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.458

High

481953

RS32B
Small ribosomal subunit protein eS32B

1

0

High-throughput

0.458

High

481959

PDR1
Transcription factor PDR1

1

0

High-throughput

0.458

High

481962

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

481971

DBP2
ATP-dependent RNA helicase DBP2

1

0

High-throughput

0.458

High

481974

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

481978

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.458

High

481995

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

482000

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

482002

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.458

High

482008

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

482021

RS26A
Small ribosomal subunit protein eS26A

1

0

High-throughput

0.458

High

482028

RIO2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.458

High

482037

RS29B
Small ribosomal subunit protein uS14B

1

0

High-throughput

0.458

High

482042

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

482051

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

482053

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.458

High

482055

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.458

High

482059

DXO
Decapping nuclease RAI1

1

0

High-throughput

0.458

High

482071

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

482076

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

482078

NACB1
Nascent polypeptide-associated complex subunit beta-1

1

0

High-throughput

0.458

High

482082

ESP1
Separin

1

0

High-throughput

0.458

High

482091

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

482092

LCB5
Sphingoid long chain base kinase 5

1

0

High-throughput

0.458

High

482097

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

482101

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

482103

AEP3
ATPase expression protein 3

1

0

Small-scale

0.458

High

482110

RS21B
Small ribosomal subunit protein eS21B

1

0

High-throughput

0.458

High

482111

RL11B
Large ribosomal subunit protein uL5B

1

0

High-throughput

0.458

High

394130

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

481440

HSP73
Heat shock protein SSA3

1

7

High-throughput

0.445

High

481954

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.445

High

481987

EF2
Elongation factor 2

1

2

High-throughput

0.445

High

481991

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

482016

CAJ1
Protein CAJ1

1

1

High-throughput

0.445

High

482023

HSP7E
Heat shock protein SSC3, mitochondrial

1

5

High-throughput

0.445

High

482027

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

482085

GCN5
Histone acetyltransferase GCN5

1

4

High-throughput

0.445

High

482096

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

High-throughput

0.445

High

427519

RLA1
Large ribosomal subunit protein P1A

1

1

High-throughput

0.437

High

427640

RLA2
Large ribosomal subunit protein P2A

1

3

High-throughput

0.437

High

438566

SC160
Protein SCP160

1

1

High-throughput

0.437

High

481961

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

481966

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.437

High

481983

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

482005

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

482019

RBG1
Ribosome-interacting GTPase 1

1

1

High-throughput

0.437

High

482032

TM108
Protein TMA108

1

1

High-throughput

0.437

High

482034

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.437

High

482035

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

482039

MID1
Stretch-activated cation channel MID1

1

1

Small-scale

0.437

High

482041

ELP2
Elongator complex protein 2

1

2

High-throughput

0.437

High

482049

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

482064

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

482067

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.437

High

482068

NST1
Stress response protein NST1

1

2

High-throughput

0.437

High

482070

FAP1
FKBP12-associated protein 1

1

2

High-throughput

0.437

High

482083

TOM1
E3 ubiquitin-protein ligase TOM1

1

6

High-throughput

0.437

High

482087

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.437

High

482093

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

453360

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

481965

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

481975

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

482043

SA155
SIT4-associating protein SAP155

1

0

High-throughput

0.426

High

482040

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

482058

SEH1
Nucleoporin SEH1

1

2

High-throughput

0.407

High

381801

H4
Histone H4

2

0

High-throughput

0.324

High

482006

HEK2
Heterogeneous nuclear rnp K-like protein 2

2

0

High-throughput

0.324

High

456481

ARD1
N-terminal acetyltransferase A complex catalytic subunit ARD1

2

0

High-throughput

0.313

High

481990

SPT16
FACT complex subunit SPT16

2

0

High-throughput

0.313

High

481982

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

2

0

High-throughput

0.307

High

482004

DPOA2
DNA polymerase alpha subunit B

2

0

High-throughput

0.307

High

482007

NCL1
Multisite-specific tRNA:(cytosine-C(5))-methyltransferase

2

0

High-throughput

0.307

High

482014

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

High-throughput

0.279

Low

482044

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.279

Low

380924

H2B1
Histone H2B.1

1

0

High-throughput

0.249

Low

481976

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

481988

SRP21
Signal recognition particle subunit SRP21

1

0

High-throughput

0.249

Low

481997

YKH1
Uncharacterized oxidoreductase YKL071W

1

0

High-throughput

0.249

Low

482012

LSM12
Protein LSM12

1

0

High-throughput

0.249

Low

482015

STM1
Suppressor protein STM1

1

0

High-throughput

0.249

Low

482025

THO1
Protein THO1

1

0

High-throughput

0.249

Low

482026

NSA2
Ribosome biogenesis protein NSA2

1

0

High-throughput

0.249

Low

482031

YIQ1
Uncharacterized protein YIL161W

1

0

High-throughput

0.249

Low

482062

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

482065

H1
Histone H1

1

0

High-throughput

0.249

Low

482081

ELP3
Elongator complex protein 3

1

0

High-throughput

0.249

Low

482086

ESC1
Silent chromatin protein ESC1

1

0

High-throughput

0.249

Low

482090

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

482094

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

482095

ESF1
Pre-rRNA-processing protein ESF1

1

0

Small-scale

0.249

Low

482098

PBP4
Protein PBP4

1

0

High-throughput

0.249

Low

482099

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

482100

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

482106

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.249

Low

481930

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.232

Low

482011

RRP4
Exosome complex component RRP4

1

0

High-throughput

0.232

Low

482030

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low

482046

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025