HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: ROA2 (P22626)
Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)
Gene: HNRNPA2B1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	32812023, 35063084, 26269332
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 353
+	Hs
		161944 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HNRDL_HUMAN (12-292): 9.81e-66: 215: 33.45
+	Hs
		201653 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MSI1H_HUMAN (3-341): 3.78e-60: 199: 28.77
+	Hs
		497424 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		MSI2H_HUMAN (1-341): 1.1e-55: 186: 27.57
+	Rn
		64991 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		ROA2_RAT (1-353): 2.59e-60: 199: 99.72
+	Rn
		64993 TAU_RAT (1-758): 4.86e-75: 260: 71.47		ROA2_RAT (1-353): 2.59e-60: 199: 99.72
+	Hs
		496957 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67
+	Hs
		496179 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PABP1_HUMAN (12-200): 2.75e-37: 143: 18.95
+	Hs
		496995 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		HNRPD_HUMAN (22-191): 3.34e-37: 138: 41.77
+	Rn
		582032 TAU_RAT (1-758): 4.86e-75: 260: 71.47		PABP1_RAT (12-200): 2.42e-37: 143: 18.95
+	Rn
		94258 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		PABP1_RAT (12-200): 2.42e-37: 143: 18.95
+	Hs
		496607 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ROA3_HUMAN (3-103): 2.78e-17: 84: 33.66
+	Hs
		453100 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ROA1_HUMAN (3-96): 6.48e-16: 79.8: 31.92
+	Rn
		582022 TAU_RAT (1-758): 4.86e-75: 260: 71.47		ROA3_RAT (3-103): 2.8e-17: 84: 33.66
+	Rn
		94248 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		ROA3_RAT (3-103): 2.8e-17: 84: 33.66
+	Mm
		498054 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		Q62029_MOUSE (102-200): 5.11e-15: 78.2: 16.00
+	Mm
		498127 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		ROA0_MOUSE (107-353): 2.11e-09: 59.8: 22.73
+	Hs
		516595 KMT2C_HUMAN (83-649): 6.28e-09: 61.8: 12.91		PABP1_HUMAN (12-200): 2.75e-37: 143: 18.95