HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: CSN5 (Q92905)
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)
Gene: COPS5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.562

Property	Details
Experiments	unassigned1973, 35063084
Identification Methods	two hybrid fragment pooling approach, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019899 - enzyme binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 334
+	Hs
		130708 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PSDE_HUMAN (50-331): 1.67e-79: 246: 31.51
+	Hs
		176928 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		EIF3H_HUMAN (52-320): 2.17e-66: 214: 18.57
+	Hs
		496602 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		PSMD7_HUMAN (52-325): 1.07e-66: 214: 14.79
+	Hs
		124742 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		EIF3F_HUMAN (44-328): 3.25e-64: 208: 14.48
+	Hs
		1056913 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		131125 PCLO_HUMAN (46-758): 3.43e-16: 85.9: 9.19		PSDE_HUMAN (50-331): 1.67e-79: 246: 31.51
+	Dm
		640790 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		PSMD7_DROME (51-325): 7.93e-65: 210: 15.04
+	Hs
		805528 MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57		BRCC3_HUMAN (56-203): 4.61e-43: 152: 21.23