HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: COF1 (P23528)
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
Gene: CFL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	35063084, 26269332
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030426 - growth cone
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 166
+	Hs
		497833 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		COF2_HUMAN (1-166): 1.68e-71: 214: 80.72
+	Hs
		496692 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		DEST_HUMAN (1-166): 3.71e-69: 208: 71.08
+	Rn
		581943 TAU_RAT (1-758): 4.86e-75: 260: 71.47		COF1_RAT (1-166): 3.11e-72: 216: 99.40
+	Rn
		94167 F1LST4_RAT (1-757): 8.59e-75: 260: 71.56		COF1_RAT (1-166): 3.11e-72: 216: 99.40
+	Mm
		497923 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		COF1_MOUSE (1-166): 1.35e-72: 217: 98.80
+	Mm
		498155 TAU_MOUSE (1-758): 1.4e-69: 244: 70.17		DEST_MOUSE (1-166): 1.45e-70: 211: 70.48
+	Hs
		496930 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TWF1_HUMAN (3-157): 1.01e-34: 126: 21.52
+	Dm
		799778 Q9VLS7_DROME (62-753): 1.93e-12: 73.2: 9.96		CADF_DROME (1-153): 1.89e-36: 124: 29.01