HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: ARHG7 (Q14155)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)
Gene: ARHGEF7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	35063084, 26269332
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0043005 - neuron projection GO:0043025 - neuronal cell body
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 803
+	Hs
		497874 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		FARP1_HUMAN (225-625): 4.7e-96: 324: 21.36
+	Hs
		497395 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		ARHG2_HUMAN (62-801): 1.23e-80: 280: 13.33
+	Hs
		279834 TAU_HUMAN (1-758): 3.6e-89: 298: 100.00		TRIO_HUMAN (16-803): 4.74e-74: 266: 13.40
+	Ce
		136804 UNC89_CAEEL (4-459): 4.47e-21: 101: 12.37		VAV_CAEEL (2-676): 1.52e-78: 275: 16.64
+	Hs
		203228 SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76		ITSN1_HUMAN (21-245): 9.17e-09: 61.3: 14.68